The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/8982 |
Resumo: | Although the cardiovascular (CV) polypill concept is not new and several guidelines state that a CV polypill should be considered an integral part of a comprehensive CV disease (CVD) prevention strategy, there are still some barriers to its implementation in the real-world setting, mainly in secondary CV prevention. As the CNIC-polypill is the only one approved for secondary CV prevention in patients with atherosclerotic CVD in 27 countries worldwide, a panel of four discussants and 30 participants from 18 countries conveyed in a virtual meeting on April 21, 2022, to discuss key clinical questions regarding the practical use of the CNIC-Polypill and barriers to its implementation. Data presented showed that, although the use of the CV polypill is not explicitly mentioned in the current 2021 European Society of Cardiology guidelines on CVD prevention, it may be used in any patient for secondary CVD prevention tolerating all their components to improve outcomes through different aspects. The favourable results of the Secondary Prevention of Cardiovascular Disease in the Elderly (SECURE) trial now reinforce this recommendation. The panellists presented algorithms on how to switch from any baseline regimen when starting treatment with the CNIC-polypill in different situations, including patients with hypertension, dyslipidaemia, and a previous CV event; at discharge after a cardiovascular event; in chronic ischemic conditions; and in cases of polypharmacy. The panellists and expert discussants did agree that available studies conducted so far with the CNIC-polypill demonstrate that it is as efficacious as the monocomponents, equipotent drugs, or other therapies; reduces the risk of experiencing recurrent major CV events; improves medication adherence; reduces health care costs and resources compared to patients treated with loose drugs; and the patients prefer it over the multipill strategy. In conclusion, the data presented by the participants provided the evidence behind the use of the CNIC-polypill to help fulfil the goal of encouraging its adoption by physicians. |
id |
RCAP_ec11fd436aa850a333a7813b663595f4 |
---|---|
oai_identifier_str |
oai:iconline.ipleiria.pt:10400.8/8982 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting reportPolypillFixed-dose combinationSecondary preventionCardiovascular diseaseCerebrovascular diseaseAlthough the cardiovascular (CV) polypill concept is not new and several guidelines state that a CV polypill should be considered an integral part of a comprehensive CV disease (CVD) prevention strategy, there are still some barriers to its implementation in the real-world setting, mainly in secondary CV prevention. As the CNIC-polypill is the only one approved for secondary CV prevention in patients with atherosclerotic CVD in 27 countries worldwide, a panel of four discussants and 30 participants from 18 countries conveyed in a virtual meeting on April 21, 2022, to discuss key clinical questions regarding the practical use of the CNIC-Polypill and barriers to its implementation. Data presented showed that, although the use of the CV polypill is not explicitly mentioned in the current 2021 European Society of Cardiology guidelines on CVD prevention, it may be used in any patient for secondary CVD prevention tolerating all their components to improve outcomes through different aspects. The favourable results of the Secondary Prevention of Cardiovascular Disease in the Elderly (SECURE) trial now reinforce this recommendation. The panellists presented algorithms on how to switch from any baseline regimen when starting treatment with the CNIC-polypill in different situations, including patients with hypertension, dyslipidaemia, and a previous CV event; at discharge after a cardiovascular event; in chronic ischemic conditions; and in cases of polypharmacy. The panellists and expert discussants did agree that available studies conducted so far with the CNIC-polypill demonstrate that it is as efficacious as the monocomponents, equipotent drugs, or other therapies; reduces the risk of experiencing recurrent major CV events; improves medication adherence; reduces health care costs and resources compared to patients treated with loose drugs; and the patients prefer it over the multipill strategy. In conclusion, the data presented by the participants provided the evidence behind the use of the CNIC-polypill to help fulfil the goal of encouraging its adoption by physicians.BMCIC-OnlineGrigorian-Shamagian, LilianCoca, AntonioMorais, JoaoPerez-Martinez, PabloBarragan, AdrianaBarrientos, Ana Isabele Silva, Alexandre AmaralSugraliyev, AkhmetzhanParkhomenko, AlexanderLiprandi, Álvaro SosaParapid, BiljanaOlivares, CarlosNegretti, Carlos Ignacio PonteQuesada, DanielKosevic, DraganaGastelum, Edith RuizLópez, Emilio Samael PeraltaAraujo, FranciscoPadilla Padilla, Francisco GerardoKrzesinski, FrançoisAlhaddad, ImadFernandez, Jose Alejandro ChavezGonzalez-Juanatey, Jose R.Arnaout, M. SamirCastellanos, MarMendez, MaximaAcevedo, MonicaKoval, OlenaJorge, PabloZelveian, ParounakKreutz, ReinholdTseluyko, Vira2023-11-29T15:54:18Z2023-08-172023-08-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8982engGrigorian-Shamagian, L., Coca, A., Morais, J. et al. The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report. BMC Proc 17 (Suppl 8), 20 (2023). https://doi.org/10.1186/s12919-023-00268-9https://doi.org/10.1186/s12919-023-00268-91753-6561info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:58:37Zoai:iconline.ipleiria.pt:10400.8/8982Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:34.427875Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
title |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
spellingShingle |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report Grigorian-Shamagian, Lilian Polypill Fixed-dose combination Secondary prevention Cardiovascular disease Cerebrovascular disease |
title_short |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
title_full |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
title_fullStr |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
title_full_unstemmed |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
title_sort |
The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report |
author |
Grigorian-Shamagian, Lilian |
author_facet |
Grigorian-Shamagian, Lilian Coca, Antonio Morais, Joao Perez-Martinez, Pablo Barragan, Adriana Barrientos, Ana Isabel e Silva, Alexandre Amaral Sugraliyev, Akhmetzhan Parkhomenko, Alexander Liprandi, Álvaro Sosa Parapid, Biljana Olivares, Carlos Negretti, Carlos Ignacio Ponte Quesada, Daniel Kosevic, Dragana Gastelum, Edith Ruiz López, Emilio Samael Peralta Araujo, Francisco Padilla Padilla, Francisco Gerardo Krzesinski, François Alhaddad, Imad Fernandez, Jose Alejandro Chavez Gonzalez-Juanatey, Jose R. Arnaout, M. Samir Castellanos, Mar Mendez, Maxima Acevedo, Monica Koval, Olena Jorge, Pablo Zelveian, Parounak Kreutz, Reinhold Tseluyko, Vira |
author_role |
author |
author2 |
Coca, Antonio Morais, Joao Perez-Martinez, Pablo Barragan, Adriana Barrientos, Ana Isabel e Silva, Alexandre Amaral Sugraliyev, Akhmetzhan Parkhomenko, Alexander Liprandi, Álvaro Sosa Parapid, Biljana Olivares, Carlos Negretti, Carlos Ignacio Ponte Quesada, Daniel Kosevic, Dragana Gastelum, Edith Ruiz López, Emilio Samael Peralta Araujo, Francisco Padilla Padilla, Francisco Gerardo Krzesinski, François Alhaddad, Imad Fernandez, Jose Alejandro Chavez Gonzalez-Juanatey, Jose R. Arnaout, M. Samir Castellanos, Mar Mendez, Maxima Acevedo, Monica Koval, Olena Jorge, Pablo Zelveian, Parounak Kreutz, Reinhold Tseluyko, Vira |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Grigorian-Shamagian, Lilian Coca, Antonio Morais, Joao Perez-Martinez, Pablo Barragan, Adriana Barrientos, Ana Isabel e Silva, Alexandre Amaral Sugraliyev, Akhmetzhan Parkhomenko, Alexander Liprandi, Álvaro Sosa Parapid, Biljana Olivares, Carlos Negretti, Carlos Ignacio Ponte Quesada, Daniel Kosevic, Dragana Gastelum, Edith Ruiz López, Emilio Samael Peralta Araujo, Francisco Padilla Padilla, Francisco Gerardo Krzesinski, François Alhaddad, Imad Fernandez, Jose Alejandro Chavez Gonzalez-Juanatey, Jose R. Arnaout, M. Samir Castellanos, Mar Mendez, Maxima Acevedo, Monica Koval, Olena Jorge, Pablo Zelveian, Parounak Kreutz, Reinhold Tseluyko, Vira |
dc.subject.por.fl_str_mv |
Polypill Fixed-dose combination Secondary prevention Cardiovascular disease Cerebrovascular disease |
topic |
Polypill Fixed-dose combination Secondary prevention Cardiovascular disease Cerebrovascular disease |
description |
Although the cardiovascular (CV) polypill concept is not new and several guidelines state that a CV polypill should be considered an integral part of a comprehensive CV disease (CVD) prevention strategy, there are still some barriers to its implementation in the real-world setting, mainly in secondary CV prevention. As the CNIC-polypill is the only one approved for secondary CV prevention in patients with atherosclerotic CVD in 27 countries worldwide, a panel of four discussants and 30 participants from 18 countries conveyed in a virtual meeting on April 21, 2022, to discuss key clinical questions regarding the practical use of the CNIC-Polypill and barriers to its implementation. Data presented showed that, although the use of the CV polypill is not explicitly mentioned in the current 2021 European Society of Cardiology guidelines on CVD prevention, it may be used in any patient for secondary CVD prevention tolerating all their components to improve outcomes through different aspects. The favourable results of the Secondary Prevention of Cardiovascular Disease in the Elderly (SECURE) trial now reinforce this recommendation. The panellists presented algorithms on how to switch from any baseline regimen when starting treatment with the CNIC-polypill in different situations, including patients with hypertension, dyslipidaemia, and a previous CV event; at discharge after a cardiovascular event; in chronic ischemic conditions; and in cases of polypharmacy. The panellists and expert discussants did agree that available studies conducted so far with the CNIC-polypill demonstrate that it is as efficacious as the monocomponents, equipotent drugs, or other therapies; reduces the risk of experiencing recurrent major CV events; improves medication adherence; reduces health care costs and resources compared to patients treated with loose drugs; and the patients prefer it over the multipill strategy. In conclusion, the data presented by the participants provided the evidence behind the use of the CNIC-polypill to help fulfil the goal of encouraging its adoption by physicians. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-29T15:54:18Z 2023-08-17 2023-08-17T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8982 |
url |
http://hdl.handle.net/10400.8/8982 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Grigorian-Shamagian, L., Coca, A., Morais, J. et al. The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease – expert panel meeting report. BMC Proc 17 (Suppl 8), 20 (2023). https://doi.org/10.1186/s12919-023-00268-9 https://doi.org/10.1186/s12919-023-00268-9 1753-6561 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMC |
publisher.none.fl_str_mv |
BMC |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137007288451072 |