Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression

Detalhes bibliográficos
Autor(a) principal: Prasad, Rajendra
Data de Publicação: 2021
Outros Autores: Jain, Nishant K., Yadav, Amit S., Jadhav, Manali, Radharani, Nalukurthi Naga Venkata, Gorain, Mahadeo, Kundu, Gopal C., Conde, João, Srivastava, Rohit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/147348
Resumo: Funding: This work was supported by Department of Biotechnology, Government of India. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). We thank the staff of animal house, NCCS, Pune for supporting us during animal studies. We also thank Mr. Sumit for the discussion and Dr. Mukesh K. Kumawat for providing GQDs.
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spelling Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regressiongraphene quantum dotsnanotheranosticphotothermal therapyporous silicasolid tumortumor regressionBiomaterialsChemistry(all)Biomedical EngineeringBiochemistry, medicalSDG 3 - Good Health and Well-beingFunding: This work was supported by Department of Biotechnology, Government of India. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). We thank the staff of animal house, NCCS, Pune for supporting us during animal studies. We also thank Mr. Sumit for the discussion and Dr. Mukesh K. Kumawat for providing GQDs.So far, near-infrared (NIR) light responsive nanostructures have been well-defined in cancer nanomedicine. However, poor penetration and retention in tumors are the limiting factors. Here, we report the ultrahigh penetration and retention of carbanosilica (graphene quantum dots, GQDs embedded mesoporous silica) in solid tumors. After NIR light exposure, quick (0.5 h) emission from the tumor area is observed that is further retained up to a week (tested up to 10 days) with a single dose administration of nanohybrids. Emissive and photothermally active GQDs and porous silica shell (about 31% drug loading) make carbanosilica a promising nanotheranostic agent exhibiting 68.75% tumor shrinking compared to without NIR light exposure (34.48%). Generated heat (∼52 °C) alters the permeability of tumor enhancing the accumulation of nanotheranostics into the tumor environment. Successive tumor imaging ensures the prolonged follow-up of image guided tumor regression due to synergistic therapeutic effect of nanohybrids.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNPrasad, RajendraJain, Nishant K.Yadav, Amit S.Jadhav, ManaliRadharani, Nalukurthi Naga VenkataGorain, MahadeoKundu, Gopal C.Conde, JoãoSrivastava, Rohit2023-01-11T22:14:45Z2021-02-152021-02-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147348eng2576-6422PURE: 27874292https://doi.org/10.1021/acsabm.0c01478info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:28:23Zoai:run.unl.pt:10362/147348Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:52.599414Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
title Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
spellingShingle Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
Prasad, Rajendra
graphene quantum dots
nanotheranostic
photothermal therapy
porous silica
solid tumor
tumor regression
Biomaterials
Chemistry(all)
Biomedical Engineering
Biochemistry, medical
SDG 3 - Good Health and Well-being
title_short Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
title_full Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
title_fullStr Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
title_full_unstemmed Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
title_sort Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression
author Prasad, Rajendra
author_facet Prasad, Rajendra
Jain, Nishant K.
Yadav, Amit S.
Jadhav, Manali
Radharani, Nalukurthi Naga Venkata
Gorain, Mahadeo
Kundu, Gopal C.
Conde, João
Srivastava, Rohit
author_role author
author2 Jain, Nishant K.
Yadav, Amit S.
Jadhav, Manali
Radharani, Nalukurthi Naga Venkata
Gorain, Mahadeo
Kundu, Gopal C.
Conde, João
Srivastava, Rohit
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv Prasad, Rajendra
Jain, Nishant K.
Yadav, Amit S.
Jadhav, Manali
Radharani, Nalukurthi Naga Venkata
Gorain, Mahadeo
Kundu, Gopal C.
Conde, João
Srivastava, Rohit
dc.subject.por.fl_str_mv graphene quantum dots
nanotheranostic
photothermal therapy
porous silica
solid tumor
tumor regression
Biomaterials
Chemistry(all)
Biomedical Engineering
Biochemistry, medical
SDG 3 - Good Health and Well-being
topic graphene quantum dots
nanotheranostic
photothermal therapy
porous silica
solid tumor
tumor regression
Biomaterials
Chemistry(all)
Biomedical Engineering
Biochemistry, medical
SDG 3 - Good Health and Well-being
description Funding: This work was supported by Department of Biotechnology, Government of India. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). We thank the staff of animal house, NCCS, Pune for supporting us during animal studies. We also thank Mr. Sumit for the discussion and Dr. Mukesh K. Kumawat for providing GQDs.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-15
2021-02-15T00:00:00Z
2023-01-11T22:14:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147348
url http://hdl.handle.net/10362/147348
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2576-6422
PURE: 27874292
https://doi.org/10.1021/acsabm.0c01478
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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