Antineoplastic drugs in urban wastewater
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/154550 |
Resumo: | Funding Information: This work was also funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior ( FCT / MCTES , Portugal) through national funds to the Associate Laboratory LS4FUTURE (LA/P/0087/2020). Funding Information: This research was financially supported by: (i) Project POCI-01-0145-FEDER-031297 (CytoStraTech)—funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT /MCTES; (ii) NORTE-01-0145-FEDER-000069 (Healthy Waters) co-funded by European Regional Development Fund ( ERDF ), through North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement; (iii) LA/P/0064/2020 (ITR), funded by national funds through the FCT - Foundation for Science and Technology, I.P.; (iv) LA/P/0045/2020 (ALiCE). Publisher Copyright: © 2023 The Authors |
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Antineoplastic drugs in urban wastewaterOccurrence, nanofiltration treatment and toxicity screeningAnticancer drugsCytostatic drugsNanofiltrationPilot-scale treatmentToxicity screeningUrban wastewaterToxicologyPollutionHealth, Toxicology and MutagenesisSDG 3 - Good Health and Well-beingSDG 11 - Sustainable Cities and CommunitiesFunding Information: This work was also funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior ( FCT / MCTES , Portugal) through national funds to the Associate Laboratory LS4FUTURE (LA/P/0087/2020). Funding Information: This research was financially supported by: (i) Project POCI-01-0145-FEDER-031297 (CytoStraTech)—funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT /MCTES; (ii) NORTE-01-0145-FEDER-000069 (Healthy Waters) co-funded by European Regional Development Fund ( ERDF ), through North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement; (iii) LA/P/0064/2020 (ITR), funded by national funds through the FCT - Foundation for Science and Technology, I.P.; (iv) LA/P/0045/2020 (ALiCE). Publisher Copyright: © 2023 The AuthorsAntineoplastic drugs are pharmaceuticals that have been raising concerns among the scientific community due to: (i) their increasing prescription in the fight against the disease of the twentieth century (cancer); (ii) their recalcitrance to conventional wastewater treatments; (iii) their poor environmental biodegradability; and (iv) their potential risk to any eukaryotic organism. This emerges the urgency in finding solutions to mitigate the entrance and accumulation of these hazardous chemicals in the environment. Advanced oxidation processes (AOPs) have been taken into consideration to improve the degradation of antineoplastic drugs in wastewater treatment plants (WWTPs), but the formation of by-products that are more toxic or exhibit a different toxicity profile than the parent drug is frequently reported. This work evaluates the performance of a nanofiltration pilot unit, equipped with a Desal 5DK membrane, in the treatment of real WWTP effluents contaminated (without spiking) with eleven pharmaceuticals, five of which were never studied before. Average removals of 68 ± 23% were achieved for the eleven compounds, with decreasing risks from feed to permeate for aquatic organisms from receiving waterbodies (with the exception of cyclophosphamide, for which a high risk was estimated in the permeate). Aditionally, no significative impact on the growth and germination of three different seeds (Lepidium sativum, Sinapis alba, and Sorghum saccharatum) were determined for permeate matrix in comparison to the control.LAQV@REQUIMTEDQ - Departamento de QuímicaInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNGouveia, Teresa I. A.Cristóvão, Maria B.Pereira, Vanessa J.Crespo, João G.Alves, ArmindaRibeiro, Ana R.Silva, AdriánSantos, Mónica S. F.2023-06-28T22:17:25Z2023-09-012023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/154550eng0269-7491PURE: 64722087https://doi.org/10.1016/j.envpol.2023.121944info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:12:26Zoai:run.unl.pt:10362/154550Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:12:26Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Antineoplastic drugs in urban wastewater Occurrence, nanofiltration treatment and toxicity screening |
| title |
Antineoplastic drugs in urban wastewater |
| spellingShingle |
Antineoplastic drugs in urban wastewater Gouveia, Teresa I. A. Anticancer drugs Cytostatic drugs Nanofiltration Pilot-scale treatment Toxicity screening Urban wastewater Toxicology Pollution Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being SDG 11 - Sustainable Cities and Communities |
| title_short |
Antineoplastic drugs in urban wastewater |
| title_full |
Antineoplastic drugs in urban wastewater |
| title_fullStr |
Antineoplastic drugs in urban wastewater |
| title_full_unstemmed |
Antineoplastic drugs in urban wastewater |
| title_sort |
Antineoplastic drugs in urban wastewater |
| author |
Gouveia, Teresa I. A. |
| author_facet |
Gouveia, Teresa I. A. Cristóvão, Maria B. Pereira, Vanessa J. Crespo, João G. Alves, Arminda Ribeiro, Ana R. Silva, Adrián Santos, Mónica S. F. |
| author_role |
author |
| author2 |
Cristóvão, Maria B. Pereira, Vanessa J. Crespo, João G. Alves, Arminda Ribeiro, Ana R. Silva, Adrián Santos, Mónica S. F. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Gouveia, Teresa I. A. Cristóvão, Maria B. Pereira, Vanessa J. Crespo, João G. Alves, Arminda Ribeiro, Ana R. Silva, Adrián Santos, Mónica S. F. |
| dc.subject.por.fl_str_mv |
Anticancer drugs Cytostatic drugs Nanofiltration Pilot-scale treatment Toxicity screening Urban wastewater Toxicology Pollution Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being SDG 11 - Sustainable Cities and Communities |
| topic |
Anticancer drugs Cytostatic drugs Nanofiltration Pilot-scale treatment Toxicity screening Urban wastewater Toxicology Pollution Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being SDG 11 - Sustainable Cities and Communities |
| description |
Funding Information: This work was also funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior ( FCT / MCTES , Portugal) through national funds to the Associate Laboratory LS4FUTURE (LA/P/0087/2020). Funding Information: This research was financially supported by: (i) Project POCI-01-0145-FEDER-031297 (CytoStraTech)—funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT /MCTES; (ii) NORTE-01-0145-FEDER-000069 (Healthy Waters) co-funded by European Regional Development Fund ( ERDF ), through North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement; (iii) LA/P/0064/2020 (ITR), funded by national funds through the FCT - Foundation for Science and Technology, I.P.; (iv) LA/P/0045/2020 (ALiCE). Publisher Copyright: © 2023 The Authors |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-06-28T22:17:25Z 2023-09-01 2023-09-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/154550 |
| url |
http://hdl.handle.net/10362/154550 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0269-7491 PURE: 64722087 https://doi.org/10.1016/j.envpol.2023.121944 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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11 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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