The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study

Detalhes bibliográficos
Autor(a) principal: Branco, M
Data de Publicação: 2020
Outros Autores: Alves, I, Martins, de Silva, A, Pinheiro, J, Sá, MJ, Correia, I, Sousa, L, Brandão, E, Veira, C, Gomes, B, Ruano, L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/143109
Resumo: Background. The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portugal. Methods. Multiple overlapping sources were used to ascertain all cases from the reference population: records from hospitals in the region and neighbouring regions; diagnostic databases of primary care physicians; and applications for disability benefits. The prevalence date was set at 1 January 2014. The reference population was 274,859 inhabitants. Patients’ neurologists were contacted to retrieve clinical information and confirm the diagnosis based. Results. A total of 177 patients were identified after eliminating duplicates from different sources. The female to male ratio was 1.9 and the mean age at disease onset was 33.5 (standard deviation: 10.3). Clinically isolated syndrome accounted for 9.0% of patients, relapsing remitting for 58.8%, secondary progressive for 20.3% and primary progressive for 11.8%. The prevalence was estimated in 64.4 patients per 100,000 (95% confidence interval: 54.9;73.9). Conclusions. In this study we report a higher point prevalence of MS than had been previously described in Portugal, but still far from the higher values recently reported in other Southern European countries.
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spelling The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based studyMultiple sclerosisEpidemiologyPrevalencePortugalBackground. The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portugal. Methods. Multiple overlapping sources were used to ascertain all cases from the reference population: records from hospitals in the region and neighbouring regions; diagnostic databases of primary care physicians; and applications for disability benefits. The prevalence date was set at 1 January 2014. The reference population was 274,859 inhabitants. Patients’ neurologists were contacted to retrieve clinical information and confirm the diagnosis based. Results. A total of 177 patients were identified after eliminating duplicates from different sources. The female to male ratio was 1.9 and the mean age at disease onset was 33.5 (standard deviation: 10.3). Clinically isolated syndrome accounted for 9.0% of patients, relapsing remitting for 58.8%, secondary progressive for 20.3% and primary progressive for 11.8%. The prevalence was estimated in 64.4 patients per 100,000 (95% confidence interval: 54.9;73.9). Conclusions. In this study we report a higher point prevalence of MS than had been previously described in Portugal, but still far from the higher values recently reported in other Southern European countries.BMC20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143109eng1471-237710.1186/s12883-020-01755-8Branco, MAlves, IMartins, de Silva, APinheiro, JSá, MJCorreia, ISousa, LBrandão, EVeira, CGomes, BRuano, Linfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T09:47:48Zoai:repositorio-aberto.up.pt:10216/143109Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T09:47:48Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
title The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
spellingShingle The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
Branco, M
Multiple sclerosis
Epidemiology
Prevalence
Portugal
title_short The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
title_full The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
title_fullStr The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
title_full_unstemmed The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
title_sort The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study
author Branco, M
author_facet Branco, M
Alves, I
Martins, de Silva, A
Pinheiro, J
Sá, MJ
Correia, I
Sousa, L
Brandão, E
Veira, C
Gomes, B
Ruano, L
author_role author
author2 Alves, I
Martins, de Silva, A
Pinheiro, J
Sá, MJ
Correia, I
Sousa, L
Brandão, E
Veira, C
Gomes, B
Ruano, L
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Branco, M
Alves, I
Martins, de Silva, A
Pinheiro, J
Sá, MJ
Correia, I
Sousa, L
Brandão, E
Veira, C
Gomes, B
Ruano, L
dc.subject.por.fl_str_mv Multiple sclerosis
Epidemiology
Prevalence
Portugal
topic Multiple sclerosis
Epidemiology
Prevalence
Portugal
description Background. The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portugal. Methods. Multiple overlapping sources were used to ascertain all cases from the reference population: records from hospitals in the region and neighbouring regions; diagnostic databases of primary care physicians; and applications for disability benefits. The prevalence date was set at 1 January 2014. The reference population was 274,859 inhabitants. Patients’ neurologists were contacted to retrieve clinical information and confirm the diagnosis based. Results. A total of 177 patients were identified after eliminating duplicates from different sources. The female to male ratio was 1.9 and the mean age at disease onset was 33.5 (standard deviation: 10.3). Clinically isolated syndrome accounted for 9.0% of patients, relapsing remitting for 58.8%, secondary progressive for 20.3% and primary progressive for 11.8%. The prevalence was estimated in 64.4 patients per 100,000 (95% confidence interval: 54.9;73.9). Conclusions. In this study we report a higher point prevalence of MS than had been previously described in Portugal, but still far from the higher values recently reported in other Southern European countries.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/143109
url https://hdl.handle.net/10216/143109
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2377
10.1186/s12883-020-01755-8
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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