Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/4934 |
Resumo: | Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse), forms proteasome-inhibiting metal complexes with copper or zinc that suppress cancer cells both in vitro and in vivo. The drug has been used in a clinical trial (NCT00742911) along with copper gluconate as a dietary supplement in patients with cancer spreading to the liver. In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds' ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48 h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes. (C) 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. |
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Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cellsDisulfiramDietary supplementsDithiocarbamate-metalCancerProteasomeCopperManganeseDiethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse), forms proteasome-inhibiting metal complexes with copper or zinc that suppress cancer cells both in vitro and in vivo. The drug has been used in a clinical trial (NCT00742911) along with copper gluconate as a dietary supplement in patients with cancer spreading to the liver. In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds' ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48 h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes. (C) 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.University South BohemiaRCIPLSedlacek, JindrichMartins, LuisaDanek, PetrPombeiro, ArmandoCvek, Boris2015-08-24T10:59:23Z2014-112014-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/4934engSEDLACEK, Jindrich; [et al] – Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells. Journal of Applied Biomedicine. ISSN: 1214-021X. Vol. 12, n.º 4 (2014), pp. 301-3081214-021X10.1016/j.jab.2014.04.002metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:47:39Zoai:repositorio.ipl.pt:10400.21/4934Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:14:17.710136Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
title |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
spellingShingle |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells Sedlacek, Jindrich Disulfiram Dietary supplements Dithiocarbamate-metal Cancer Proteasome Copper Manganese |
title_short |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
title_full |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
title_fullStr |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
title_full_unstemmed |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
title_sort |
Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells |
author |
Sedlacek, Jindrich |
author_facet |
Sedlacek, Jindrich Martins, Luisa Danek, Petr Pombeiro, Armando Cvek, Boris |
author_role |
author |
author2 |
Martins, Luisa Danek, Petr Pombeiro, Armando Cvek, Boris |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Sedlacek, Jindrich Martins, Luisa Danek, Petr Pombeiro, Armando Cvek, Boris |
dc.subject.por.fl_str_mv |
Disulfiram Dietary supplements Dithiocarbamate-metal Cancer Proteasome Copper Manganese |
topic |
Disulfiram Dietary supplements Dithiocarbamate-metal Cancer Proteasome Copper Manganese |
description |
Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse), forms proteasome-inhibiting metal complexes with copper or zinc that suppress cancer cells both in vitro and in vivo. The drug has been used in a clinical trial (NCT00742911) along with copper gluconate as a dietary supplement in patients with cancer spreading to the liver. In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds' ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48 h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes. (C) 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11 2014-11-01T00:00:00Z 2015-08-24T10:59:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/4934 |
url |
http://hdl.handle.net/10400.21/4934 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
SEDLACEK, Jindrich; [et al] – Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells. Journal of Applied Biomedicine. ISSN: 1214-021X. Vol. 12, n.º 4 (2014), pp. 301-308 1214-021X 10.1016/j.jab.2014.04.002 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
University South Bohemia |
publisher.none.fl_str_mv |
University South Bohemia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133400534089728 |