Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study

Detalhes bibliográficos
Autor(a) principal: M. Oliveira, Andreia
Data de Publicação: 2023
Outros Autores: Ferreira Coelho , Catarina, Lourenço, Filipa, Campos Pinto, Inês, Atabão, Joana, Cabrita, Raquel, Paraíso, Rita, Mesquita, Edgar, Torrado, Dyna, Marquez, Pilar, Z. Guerreiro, Vanessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19566
Resumo: Introduction: The COVID-19 pandemic has presented numerous challenges to healthcare systems. As the number of affected individuals continues to rise, it is crucial to find preventive, diagnostic, and therapeutic approaches. This study aims to describe different COVID-19 sequelae within a Primary Health Care population. Methods: A retrospective cohort study was conducted in adults diagnosed with COVID-19 from March 2020 to April 2022, excluding pregnant women, minors, nursing home residents, hospitalizations, and deaths. Data was gathered from surveillance records on the Trace COVID-19® platform, a pre-set original questionnaire (which included the Portuguese version of the World Health Organization’s Quality of Life Assessment Instrument), and, if needed, patient electronic health records. Information on sociodemographic and clinical characteristics of acute COVID-19 was collected along with long COVID symptoms. Results: This study included 284 patients, aged 19 to 99 years old. The five most prevalent acute COVID-19 symptoms were fever (50.0%), tiredness (48.2%), myalgias (44.7%), dry cough (37.7%) and odynophagia (36.3%). Symptoms related to the neurological system (23.2%) and tiredness (22.9%) were the most prevalent in long COVID symptoms. Acute tiredness and arthralgia were associated with all long COVID outcomes. The associations between acute COVID-19 symptoms with long COVID outcomes were stronger for anosmia [OR = 5.07, 95% confidence interval (CI) 2.49 - 10.36, p < 0.001] on a neurological chapter, acute tiredness for long lasting tiredness (OR = 4.07, 95% CI 2.07 - 8.02, p = 0.041), fatigue for muscles and/or bones chapter (OR = 7.55, 95% CI 3.06 - 18.66, p < 0.001), tiredness on an endocrine/hormonal chapter (OR = 6.54, 95% CI 2.37 - 18.04, p < 0.001), dyspnea for respiratory symptoms (OR = 5.67, 95% CI 1.92 - 16.74, p = 0.002) and fever for stomach or intestine symptoms (OR = 8.06, 95% CI 2.55 - 25.47, p < 0.001). Almost all quality of life dimensions were negatively associated with the number of long COVID symptoms. Conclusion: A higher number of acute symptoms, as well as the presence of specific COVID-19 symptoms were associated with reported symptoms ≥ 12 weeks after infection. In the studied population, an increased number of symptoms in both acute and long COVID had a significant negative impact on the perception of overall quality of life. The identification of these relationships could provide a new perspective for post-COVID care.
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spelling Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective StudySintomas Long COVID em Doentes Não Hospitalizados: Um Estudo RetrospetivoCOVID-19/complicaçõesCuidados de Saúde PrimáriosSíndrome Pós-COVID-19 AgudaCOVID-19/complicationsPost-Acute COVID-19 SyndromePrimary Health CareIntroduction: The COVID-19 pandemic has presented numerous challenges to healthcare systems. As the number of affected individuals continues to rise, it is crucial to find preventive, diagnostic, and therapeutic approaches. This study aims to describe different COVID-19 sequelae within a Primary Health Care population. Methods: A retrospective cohort study was conducted in adults diagnosed with COVID-19 from March 2020 to April 2022, excluding pregnant women, minors, nursing home residents, hospitalizations, and deaths. Data was gathered from surveillance records on the Trace COVID-19® platform, a pre-set original questionnaire (which included the Portuguese version of the World Health Organization’s Quality of Life Assessment Instrument), and, if needed, patient electronic health records. Information on sociodemographic and clinical characteristics of acute COVID-19 was collected along with long COVID symptoms. Results: This study included 284 patients, aged 19 to 99 years old. The five most prevalent acute COVID-19 symptoms were fever (50.0%), tiredness (48.2%), myalgias (44.7%), dry cough (37.7%) and odynophagia (36.3%). Symptoms related to the neurological system (23.2%) and tiredness (22.9%) were the most prevalent in long COVID symptoms. Acute tiredness and arthralgia were associated with all long COVID outcomes. The associations between acute COVID-19 symptoms with long COVID outcomes were stronger for anosmia [OR = 5.07, 95% confidence interval (CI) 2.49 - 10.36, p < 0.001] on a neurological chapter, acute tiredness for long lasting tiredness (OR = 4.07, 95% CI 2.07 - 8.02, p = 0.041), fatigue for muscles and/or bones chapter (OR = 7.55, 95% CI 3.06 - 18.66, p < 0.001), tiredness on an endocrine/hormonal chapter (OR = 6.54, 95% CI 2.37 - 18.04, p < 0.001), dyspnea for respiratory symptoms (OR = 5.67, 95% CI 1.92 - 16.74, p = 0.002) and fever for stomach or intestine symptoms (OR = 8.06, 95% CI 2.55 - 25.47, p < 0.001). Almost all quality of life dimensions were negatively associated with the number of long COVID symptoms. Conclusion: A higher number of acute symptoms, as well as the presence of specific COVID-19 symptoms were associated with reported symptoms ≥ 12 weeks after infection. In the studied population, an increased number of symptoms in both acute and long COVID had a significant negative impact on the perception of overall quality of life. The identification of these relationships could provide a new perspective for post-COVID care.Introdução: A pandemia de COVID-19 trouxe desafios aos serviços de saúde. À medida que o número de indivíduos afetados aumenta, é crucial encontrar abordagens preventivas, diagnósticas e terapêuticas. Este estudo tem como objetivo descrever diferentes sequelas de COVID-19 numa população dos Cuidados de Saúde Primários. Métodos: Estudo de coorte retrospetivo de indivíduos adultos diagnosticados com COVID-19 entre março 2020 e abril 2022, excluindo grávidas, menores, residentes em Estrutura Residencial para Pessoas Idosas, internados e óbitos. Colheu-se informação através da plataforma Trace COVID-19®, um questionário pré-estabelecido (que incluiu a versão portuguesa do Instrumento Abreviado de Avaliação da Qualidade de Vida da Organização Mundial da Saúde) e, quando necessário, registos clínicos dos utentes. Foi obtida informação sobre as características sociodemográficas e clínicas no momento de infeção aguda juntamente com sintomas de long COVID. Resultados: Estudaram-se 284 doentes com COVID-19, entre os 19 e os 99 anos. Os cinco sintomas agudos de COVID-19 mais prevalentes foram febre (50,0%), cansaço (48,2%), mialgias (44,7%), tosse seca (37,7%) e odinofagia (36,3%). Os sintomas relacionados ao sistema neurológico (23,2%) e cansaço (22,9%) foram os mais prevalentes na long COVID. Cansaço e artralgia agudos foram associados a todas as situações de long COVID. Associações entre sintomas agudos e sintomas de long COVID foram maiores entre anosmia e capítulo neurológico [OR = 5,07, intervalo de confiança (IC) 95%, 2,49 – 10,36, p < 0,001], cansaço agudo e cansaço prolongado (OR = 4,07, IC 95%, 2,07 – 8,02 p =0,041), fadiga e capítulo músculo/esquelético (OR = 7,55, IC 95%, 3,06 – 18,66, p < 0,001), cansaço e capítulo endócrino/hormonal (OR = 6.54, IC 95%, 2,37 – 18,04, p < 0,001), dispneia e sintomas respiratórios (OR = 5,67 IC 95% 1,92 – 16,74, p = 0,002) e por fim febre e capítulo gastrointestinal (OR = 8,06, IC 95%, 2,55 – 25,47, p < 0,001). Quase todas as dimensões da qualidade de vida foram associadas negativamente ao número de sintomas de long COVID. Conclusão: Um maior número de sintomas agudos, bem como a presença de sintomas específicos de COVID-19, foram associados a sintomatologia ≥ 12 semanas após a infeção. Na população estudada, um aumento no número de sintomas, quer na COVID aguda quer na long COVID, teve um impacto negativo significativo na perceção da qualidade de vida geral. A identificação dessas relações poderá trazer uma nova perspetiva de cuidados pós-COVID.Ordem dos Médicos2023-08-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19566Acta Médica Portuguesa; Vol. 36 No. 10 (2023): October; 618-630Acta Médica Portuguesa; Vol. 36 N.º 10 (2023): Outubro; 618-6301646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19566https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19566/15239Direitos de Autor (c) 2023 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessM. Oliveira, AndreiaFerreira Coelho , CatarinaLourenço, FilipaCampos Pinto, InêsAtabão, JoanaCabrita, RaquelParaíso, RitaMesquita, EdgarTorrado, DynaMarquez, PilarZ. Guerreiro, Vanessa2023-10-08T03:00:15Zoai:ojs.www.actamedicaportuguesa.com:article/19566Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:28:12.224593Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
Sintomas Long COVID em Doentes Não Hospitalizados: Um Estudo Retrospetivo
title Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
spellingShingle Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
M. Oliveira, Andreia
COVID-19/complicações
Cuidados de Saúde Primários
Síndrome Pós-COVID-19 Aguda
COVID-19/complications
Post-Acute COVID-19 Syndrome
Primary Health Care
title_short Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
title_full Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
title_fullStr Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
title_full_unstemmed Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
title_sort Long COVID Symptoms in Non-Hospitalised Patients: A Retrospective Study
author M. Oliveira, Andreia
author_facet M. Oliveira, Andreia
Ferreira Coelho , Catarina
Lourenço, Filipa
Campos Pinto, Inês
Atabão, Joana
Cabrita, Raquel
Paraíso, Rita
Mesquita, Edgar
Torrado, Dyna
Marquez, Pilar
Z. Guerreiro, Vanessa
author_role author
author2 Ferreira Coelho , Catarina
Lourenço, Filipa
Campos Pinto, Inês
Atabão, Joana
Cabrita, Raquel
Paraíso, Rita
Mesquita, Edgar
Torrado, Dyna
Marquez, Pilar
Z. Guerreiro, Vanessa
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv M. Oliveira, Andreia
Ferreira Coelho , Catarina
Lourenço, Filipa
Campos Pinto, Inês
Atabão, Joana
Cabrita, Raquel
Paraíso, Rita
Mesquita, Edgar
Torrado, Dyna
Marquez, Pilar
Z. Guerreiro, Vanessa
dc.subject.por.fl_str_mv COVID-19/complicações
Cuidados de Saúde Primários
Síndrome Pós-COVID-19 Aguda
COVID-19/complications
Post-Acute COVID-19 Syndrome
Primary Health Care
topic COVID-19/complicações
Cuidados de Saúde Primários
Síndrome Pós-COVID-19 Aguda
COVID-19/complications
Post-Acute COVID-19 Syndrome
Primary Health Care
description Introduction: The COVID-19 pandemic has presented numerous challenges to healthcare systems. As the number of affected individuals continues to rise, it is crucial to find preventive, diagnostic, and therapeutic approaches. This study aims to describe different COVID-19 sequelae within a Primary Health Care population. Methods: A retrospective cohort study was conducted in adults diagnosed with COVID-19 from March 2020 to April 2022, excluding pregnant women, minors, nursing home residents, hospitalizations, and deaths. Data was gathered from surveillance records on the Trace COVID-19® platform, a pre-set original questionnaire (which included the Portuguese version of the World Health Organization’s Quality of Life Assessment Instrument), and, if needed, patient electronic health records. Information on sociodemographic and clinical characteristics of acute COVID-19 was collected along with long COVID symptoms. Results: This study included 284 patients, aged 19 to 99 years old. The five most prevalent acute COVID-19 symptoms were fever (50.0%), tiredness (48.2%), myalgias (44.7%), dry cough (37.7%) and odynophagia (36.3%). Symptoms related to the neurological system (23.2%) and tiredness (22.9%) were the most prevalent in long COVID symptoms. Acute tiredness and arthralgia were associated with all long COVID outcomes. The associations between acute COVID-19 symptoms with long COVID outcomes were stronger for anosmia [OR = 5.07, 95% confidence interval (CI) 2.49 - 10.36, p < 0.001] on a neurological chapter, acute tiredness for long lasting tiredness (OR = 4.07, 95% CI 2.07 - 8.02, p = 0.041), fatigue for muscles and/or bones chapter (OR = 7.55, 95% CI 3.06 - 18.66, p < 0.001), tiredness on an endocrine/hormonal chapter (OR = 6.54, 95% CI 2.37 - 18.04, p < 0.001), dyspnea for respiratory symptoms (OR = 5.67, 95% CI 1.92 - 16.74, p = 0.002) and fever for stomach or intestine symptoms (OR = 8.06, 95% CI 2.55 - 25.47, p < 0.001). Almost all quality of life dimensions were negatively associated with the number of long COVID symptoms. Conclusion: A higher number of acute symptoms, as well as the presence of specific COVID-19 symptoms were associated with reported symptoms ≥ 12 weeks after infection. In the studied population, an increased number of symptoms in both acute and long COVID had a significant negative impact on the perception of overall quality of life. The identification of these relationships could provide a new perspective for post-COVID care.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-29
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19566/15239
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2023 Acta Médica Portuguesa
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rights_invalid_str_mv Direitos de Autor (c) 2023 Acta Médica Portuguesa
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 36 No. 10 (2023): October; 618-630
Acta Médica Portuguesa; Vol. 36 N.º 10 (2023): Outubro; 618-630
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