Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility

Detalhes bibliográficos
Autor(a) principal: Botelho, M.C.
Data de Publicação: 2017
Outros Autores: Alves, H., Richter, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4821
Resumo: Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations. Here we review recent findings on the role of estrogen-DNA adducts and how their shedding in urine may be prognostic of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.
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spelling Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertilityBiomarkersBladder CancerEstrogen MetabolitesInfertilitySchistosoma HaematobiumUrogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations. Here we review recent findings on the role of estrogen-DNA adducts and how their shedding in urine may be prognostic of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274).SM GroupRepositório Científico do Instituto Nacional de SaúdeBotelho, M.C.Alves, H.Richter, J.2017-11-03T16:53:27Z2017-012017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4821engLett Drug Des Discov. 2017;14(2):135-138.1570-1808info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:28Zoai:repositorio.insa.pt:10400.18/4821Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:28.126183Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
title Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
spellingShingle Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
Botelho, M.C.
Biomarkers
Bladder Cancer
Estrogen Metabolites
Infertility
Schistosoma Haematobium
title_short Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
title_full Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
title_fullStr Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
title_full_unstemmed Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
title_sort Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility
author Botelho, M.C.
author_facet Botelho, M.C.
Alves, H.
Richter, J.
author_role author
author2 Alves, H.
Richter, J.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Botelho, M.C.
Alves, H.
Richter, J.
dc.subject.por.fl_str_mv Biomarkers
Bladder Cancer
Estrogen Metabolites
Infertility
Schistosoma Haematobium
topic Biomarkers
Bladder Cancer
Estrogen Metabolites
Infertility
Schistosoma Haematobium
description Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations. Here we review recent findings on the role of estrogen-DNA adducts and how their shedding in urine may be prognostic of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-03T16:53:27Z
2017-01
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4821
url http://hdl.handle.net/10400.18/4821
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lett Drug Des Discov. 2017;14(2):135-138.
1570-1808
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SM Group
publisher.none.fl_str_mv SM Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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