Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery

Detalhes bibliográficos
Autor(a) principal: Chandra, Dilip Kumar
Data de Publicação: 2023
Outros Autores: Reis, R. L., Kundu, Subhas C, Kumar, Awanish, Mahapatra, Chinmaya
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/89268
Resumo: Carbon nanotubes (CNTs) have emerged as the brightest nascent artifact to deliver antifungal drugs in drug delivery applications, health care, and pharmaceutical industries. Excellent physio-chemical features such as huge surface area, tunable side wall, and microneedle-like morphology make CNTs suitable for drug carriers. Chemical attachments (covalent and non-covalent functionalization) result in the formation of functionalized CNTs (F-CNTs) and CNT-based hybrid materials (CNT-HMs). These F-CNTs and CNT-HMs have substantial antifungal activity and also have the potential to immobilize antifungal drugs such as amphotericin B, nystatin, curcumin, etc. on the exterior or interior surface, securely transport to the target sites, permeate through bio-barriers, and release these drugs in a controlled manner. As antifungal drug carriers, F-CNT and CNT-HMs exhibit more excellent antifungal activity than other conventional drug delivery systems and have the potency to invade biofilm to circumvent the multidrug resistance of fungal species. This review focuses on CNTs and CNT-HMs for antifungal drug delivery, including their functionalization methods, drug loading approaches, drug release mechanism, cellular internalization, delivery efficiency, and cellular toxicities with their workaround.
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spelling Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug deliveryAntifungal drugsCarbon nanotubesDrug delivery systemsFunctionalizationNanocarriersPertinent antifungal therapeuticsCarbon nanotubes (CNTs) have emerged as the brightest nascent artifact to deliver antifungal drugs in drug delivery applications, health care, and pharmaceutical industries. Excellent physio-chemical features such as huge surface area, tunable side wall, and microneedle-like morphology make CNTs suitable for drug carriers. Chemical attachments (covalent and non-covalent functionalization) result in the formation of functionalized CNTs (F-CNTs) and CNT-based hybrid materials (CNT-HMs). These F-CNTs and CNT-HMs have substantial antifungal activity and also have the potential to immobilize antifungal drugs such as amphotericin B, nystatin, curcumin, etc. on the exterior or interior surface, securely transport to the target sites, permeate through bio-barriers, and release these drugs in a controlled manner. As antifungal drug carriers, F-CNT and CNT-HMs exhibit more excellent antifungal activity than other conventional drug delivery systems and have the potency to invade biofilm to circumvent the multidrug resistance of fungal species. This review focuses on CNTs and CNT-HMs for antifungal drug delivery, including their functionalization methods, drug loading approaches, drug release mechanism, cellular internalization, delivery efficiency, and cellular toxicities with their workaround.C.M. acknowledges the National Institute of Technology Raipur for SeedGrant, project no: NITRR/Seed Grant/2021-22/30. C.M. gratefully accepted the Science & Engineering Research Board (SERB) research support vide grant number SRG/2022/000348 from the Department of Science and Technology, India.WileyUniversidade do MinhoChandra, Dilip KumarReis, R. L.Kundu, Subhas CKumar, AwanishMahapatra, Chinmaya2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/89268engChandra D. K., Reis R. L., Kundu S. C., Kumar A., Mahapatra C. Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery, Advanced Materials Technologies, Vol. 8, Issue 23, pp. 2301044 , doi:10.1002/admt.202301044, 20232365-709X10.1002/admt.202301044https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202301044info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-09T01:19:46Zoai:repositorium.sdum.uminho.pt:1822/89268Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:13:59.620845Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
title Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
spellingShingle Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
Chandra, Dilip Kumar
Antifungal drugs
Carbon nanotubes
Drug delivery systems
Functionalization
Nanocarriers
Pertinent antifungal therapeutics
title_short Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
title_full Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
title_fullStr Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
title_full_unstemmed Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
title_sort Carbon nanotube hybrid materials: efficient and pertinent platforms for antifungal drug delivery
author Chandra, Dilip Kumar
author_facet Chandra, Dilip Kumar
Reis, R. L.
Kundu, Subhas C
Kumar, Awanish
Mahapatra, Chinmaya
author_role author
author2 Reis, R. L.
Kundu, Subhas C
Kumar, Awanish
Mahapatra, Chinmaya
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Chandra, Dilip Kumar
Reis, R. L.
Kundu, Subhas C
Kumar, Awanish
Mahapatra, Chinmaya
dc.subject.por.fl_str_mv Antifungal drugs
Carbon nanotubes
Drug delivery systems
Functionalization
Nanocarriers
Pertinent antifungal therapeutics
topic Antifungal drugs
Carbon nanotubes
Drug delivery systems
Functionalization
Nanocarriers
Pertinent antifungal therapeutics
description Carbon nanotubes (CNTs) have emerged as the brightest nascent artifact to deliver antifungal drugs in drug delivery applications, health care, and pharmaceutical industries. Excellent physio-chemical features such as huge surface area, tunable side wall, and microneedle-like morphology make CNTs suitable for drug carriers. Chemical attachments (covalent and non-covalent functionalization) result in the formation of functionalized CNTs (F-CNTs) and CNT-based hybrid materials (CNT-HMs). These F-CNTs and CNT-HMs have substantial antifungal activity and also have the potential to immobilize antifungal drugs such as amphotericin B, nystatin, curcumin, etc. on the exterior or interior surface, securely transport to the target sites, permeate through bio-barriers, and release these drugs in a controlled manner. As antifungal drug carriers, F-CNT and CNT-HMs exhibit more excellent antifungal activity than other conventional drug delivery systems and have the potency to invade biofilm to circumvent the multidrug resistance of fungal species. This review focuses on CNTs and CNT-HMs for antifungal drug delivery, including their functionalization methods, drug loading approaches, drug release mechanism, cellular internalization, delivery efficiency, and cellular toxicities with their workaround.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
2023-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/89268
url https://hdl.handle.net/1822/89268
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chandra D. K., Reis R. L., Kundu S. C., Kumar A., Mahapatra C. Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery, Advanced Materials Technologies, Vol. 8, Issue 23, pp. 2301044 , doi:10.1002/admt.202301044, 2023
2365-709X
10.1002/admt.202301044
https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202301044
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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