BCR-ABL V280G mutation, potential role in imatinib resistance: First case report

• Autor(a) principal: Azevedo, A.P.
• Data de Publicação: 2017
• Outros Autores: Reichert, A., Afonso, C., Alberca, M.D., Tavares, P., Lima, F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.1177/1179554917702870
• topic: BCR-ABL; CML; Imatinib; Mutation; Nilotinib; alpha interferon; BCR ABL protein; glycine; hydroxyurea; imatinib; nilotinib; valine; aged; amino acid substitution; Article; BCR ABL gene; case report; chromosome 22; chromosome 9; chronic myeloid leukemia; clinical article; disease course; drug dose escalation; drug withdrawal; EUTOS score; female; gene; gene mutation; gene sequence; Hasford score; human; leukoderma; reverse transcription polymerase chain reaction; Sokal score; splenomegaly; SDG 3 - Good Health and Well-being

Export Date: 28 December 2017 Correspondence Address: Azevedo, A.P.; Department of Clinical Pathology, Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Estrada do Forte do Alto do Duque, Portugal; email: [e-mail] Chemicals/CAS: glycine, 56-40-6, 6000-43-7, 6000-44-8; hydroxyurea, 127-07-1; imatinib, 152459-95-5, 220127-57-1; nilotinib, 641571-10-0; valine, 7004-03-7, 72-18-4 References: Radich, J.P., Shah, N.P., Mauro, M.J., Integrating current treatment options for TKIresistant chronic myeloid leukemia (2014) Clin Adv Hematol Oncol, 12 (11), pp. 3-17; Savona, M.R., Molecular monitoring and minimal residual disease in the management of chronic myelogenous leukemia (2014) J Community Support Oncol, 12, pp. 171-178; Kantarjian, H.M., Cortes, J., La Rosée, P., Hochhaus, A., Optimizing therapy for patients with chronic myelogenous leukemia in chronic phase (2010) Cancer, 116, pp. 1419-1430; Weisberg, E., Manley, P.W., Cowan-Jacob, S.W., Hochhaus, A., Griffin, J.D., Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia (2007) Nat Rev Cancer, 7, pp. 345-356; Nicolini, F.E., Corm, S., Lê, Q.H., Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP) (2006) Leukemia, 20, pp. 1061-1066; Soverini, S., Colarossi, S., Gnani, A., Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia (2006) Clin Cancer Res, 12, pp. 7374-7379; Sokal, J.E., Cox, E.B., Baccarani, M., Prognostic discrimination in “good-risk” chronic granulocytic leukemia (1984) Blood, 63, pp. 789-799; Hasford, J., Pfirrmann, M., Hehlmann, R., A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. 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