The positive effect on ketamine as a priming adjuvant in antidepressant treatment.

Detalhes bibliográficos
Autor(a) principal: Almeida, António Manuel Melo Soares
Data de Publicação: 2015
Outros Autores: Kokras, N., Dalla, C., Ferreira, Ana Catarina, Silva, Ana Paula Ventura, Sousa, Nuno, Pêgo, José M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/41040
Resumo: Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD.
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spelling The positive effect on ketamine as a priming adjuvant in antidepressant treatment.Ciências Médicas::Medicina BásicaScience & TechnologyKetamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD.This work is supported by the Fundação para a Ciência e Tecnologia (FCT) grant SFRH/SINTD/60126/2009Nature Publishing GroupUniversidade do MinhoAlmeida, António Manuel Melo SoaresKokras, N.Dalla, C.Ferreira, Ana CatarinaSilva, Ana Paula VenturaSousa, NunoPêgo, José M.2015-052015-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/41040engMelo, A., Kokras, N., Dalla, C., Ferreira, C., Ventura-Silva, A. P., Sousa, N., & Pêgo, J. M. (2015). The positive effect on ketamine as a priming adjuvant in antidepressant treatment. Translational psychiatry, 5(5)2158-318810.1038/tp.2015.6626080090http://www.nature.com/tp/journal/v5/n5/abs/tp201566a.htmlinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:18Zoai:repositorium.sdum.uminho.pt:1822/41040Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:16:59.109304Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
title The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
spellingShingle The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
Almeida, António Manuel Melo Soares
Ciências Médicas::Medicina Básica
Science & Technology
title_short The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
title_full The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
title_fullStr The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
title_full_unstemmed The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
title_sort The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
author Almeida, António Manuel Melo Soares
author_facet Almeida, António Manuel Melo Soares
Kokras, N.
Dalla, C.
Ferreira, Ana Catarina
Silva, Ana Paula Ventura
Sousa, Nuno
Pêgo, José M.
author_role author
author2 Kokras, N.
Dalla, C.
Ferreira, Ana Catarina
Silva, Ana Paula Ventura
Sousa, Nuno
Pêgo, José M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Almeida, António Manuel Melo Soares
Kokras, N.
Dalla, C.
Ferreira, Ana Catarina
Silva, Ana Paula Ventura
Sousa, Nuno
Pêgo, José M.
dc.subject.por.fl_str_mv Ciências Médicas::Medicina Básica
Science & Technology
topic Ciências Médicas::Medicina Básica
Science & Technology
description Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
2015-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/41040
url http://hdl.handle.net/1822/41040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Melo, A., Kokras, N., Dalla, C., Ferreira, C., Ventura-Silva, A. P., Sousa, N., & Pêgo, J. M. (2015). The positive effect on ketamine as a priming adjuvant in antidepressant treatment. Translational psychiatry, 5(5)
2158-3188
10.1038/tp.2015.66
26080090
http://www.nature.com/tp/journal/v5/n5/abs/tp201566a.html
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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