Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/8709 |
Resumo: | Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of earlylife exposure to PM in ASD clinical severity. |
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Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum DisorderAir PollutionAutism Spectrum DisorderClinical SeverityEarly-life ExposureParticulate MatterPregnancyPerturbações do Desenvolvimento Infantil e Saúde MentalAutismoPortugalEarly-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of earlylife exposure to PM in ASD clinical severity.This work was supported by Fundaçao ˜ para a Ciˆencia e a Tecnologia (FCT), through funding to the project “Gene-environment interactions in Autism Spectrum Disorder” (Grant PTDC/MED-OUT/28937/2017) and to Research Center Grants UIDB/04046/2020 and UIDP/04046/2020 (to BioISI) and UIDB/00006/2020 (to Centro de Estatística e Aplicaçoes ˜ da Universidade de Lisboa). Joao ˜ Xavier Santos is a fellow of the BioSys PhD Program and an awardee of a scholarship funded by FCT with reference PD/BD/114,386/2016.ElsevierRepositório Científico do Instituto Nacional de SaúdeSantos, João XavierSampaio, PedroRasga, CéliaMartiniano, HugoFaria, ClarissaCafé, CátiaOliveira, AlexandraDuque, FredericoOliveira, GuiomarSousa, LiseteNunes, AnaMoura Vicente, Astrid2023-10-11T15:23:43Z2023-04-052023-04-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8709engEnviron Res. 2023 Jul 1;228:115795. doi: 10.1016/j.envres.2023.115795. Epub 5 April 20230013-935110.1016/j.envres.2023.115795info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:32:01Zoai:repositorio.insa.pt:10400.18/8709Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:35:34.278893Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
title |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
spellingShingle |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder Santos, João Xavier Air Pollution Autism Spectrum Disorder Clinical Severity Early-life Exposure Particulate Matter Pregnancy Perturbações do Desenvolvimento Infantil e Saúde Mental Autismo Portugal |
title_short |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
title_full |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
title_fullStr |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
title_full_unstemmed |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
title_sort |
Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
author |
Santos, João Xavier |
author_facet |
Santos, João Xavier Sampaio, Pedro Rasga, Célia Martiniano, Hugo Faria, Clarissa Café, Cátia Oliveira, Alexandra Duque, Frederico Oliveira, Guiomar Sousa, Lisete Nunes, Ana Moura Vicente, Astrid |
author_role |
author |
author2 |
Sampaio, Pedro Rasga, Célia Martiniano, Hugo Faria, Clarissa Café, Cátia Oliveira, Alexandra Duque, Frederico Oliveira, Guiomar Sousa, Lisete Nunes, Ana Moura Vicente, Astrid |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Santos, João Xavier Sampaio, Pedro Rasga, Célia Martiniano, Hugo Faria, Clarissa Café, Cátia Oliveira, Alexandra Duque, Frederico Oliveira, Guiomar Sousa, Lisete Nunes, Ana Moura Vicente, Astrid |
dc.subject.por.fl_str_mv |
Air Pollution Autism Spectrum Disorder Clinical Severity Early-life Exposure Particulate Matter Pregnancy Perturbações do Desenvolvimento Infantil e Saúde Mental Autismo Portugal |
topic |
Air Pollution Autism Spectrum Disorder Clinical Severity Early-life Exposure Particulate Matter Pregnancy Perturbações do Desenvolvimento Infantil e Saúde Mental Autismo Portugal |
description |
Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of earlylife exposure to PM in ASD clinical severity. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-11T15:23:43Z 2023-04-05 2023-04-05T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8709 |
url |
http://hdl.handle.net/10400.18/8709 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environ Res. 2023 Jul 1;228:115795. doi: 10.1016/j.envres.2023.115795. Epub 5 April 2023 0013-9351 10.1016/j.envres.2023.115795 |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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