Sleep symptoms are essential features of long-COVID – comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II)

• Autor(a) principal: Merikanto, Ilona
• Data de Publicação: 2022
• Outros Autores: Dauvilliers, Yves, Chung, Frances, Wing, Yun Kwok, de Gennaro, Luigi, Holzinger, Brigitte, Bjorvatn, Bjørn, Morin, Charles M., Penzel, Thomas, Benedict, Christian, Koscec Bjelajac, Adrijana, Chan, Ngan Yin, Espie, Colin A., Hrubos-Strøm, Harald, Inoue, Yuichi, Korman, Maria, Landtblom, Anne Marie, Léger, Damien, Matsui, Kentaro, Mota-Rolim, Sergio, Nadorff, Michael R., Plazzi, Giuseppe, Reis, Cátia, Yordanova, Juliana, Partinen, Markku
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.14/39145
• topic: COVID-19; Excessive daytime sleepiness; Fatigue; Insomnia; Pandemic; Post-acute sequelae of COVID-19

Many people report suffering from post-acute sequelae of COVID-19 or “long-COVID”, but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18–99 years from 16 countries of Asia, Europe, North America and South America (May–Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.