PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY

Detalhes bibliográficos
Autor(a) principal: Araújo, Catarina
Data de Publicação: 2015
Outros Autores: Resende, Cristina, Vieira, Ana Paula, Fernandes, José Carlos, Brito, Celeste
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.73.1.357
Resumo: Introduction: Psoriasis occurs in up to 8% of patients with Down syndrome and, although poorly characterized, appears to be correlated with immune imbalance in cells Th1 and biochemical changes of cyclic nucleotides.Case report: Female patient, 38 years old, with Down syndrome and psoriasis (initial PASI 30) since 18 years. Initially treated with cyclosporine and methotrexate and subsequently with etanercept, adalimumab and ustecinumab because of progressive loss of response (current PASI 10).Conclusion: We describe this case for the poor response to treatment including various biological agents. Potential poor adherence to therapy and immune dysfunction may limit the therapeutic options.
id RCAP_ee673e944422ef9b5b24ad1841760605
oai_identifier_str oai:ojs.revista.spdv.com.pt:article/357
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTYPSORÍASE EM PLACAS EM DOENTE COM SÍNDROME DE DOWN - POTENCIAL PATOFISIOLOGIA COMUM E DIFICULDADE DE TRATAMENTOAntibodiesmonoclonalDown syndromePsoriasisAnticorpos monoclonaisPsoríaseSíndrome de DownIntroduction: Psoriasis occurs in up to 8% of patients with Down syndrome and, although poorly characterized, appears to be correlated with immune imbalance in cells Th1 and biochemical changes of cyclic nucleotides.Case report: Female patient, 38 years old, with Down syndrome and psoriasis (initial PASI 30) since 18 years. Initially treated with cyclosporine and methotrexate and subsequently with etanercept, adalimumab and ustecinumab because of progressive loss of response (current PASI 10).Conclusion: We describe this case for the poor response to treatment including various biological agents. Potential poor adherence to therapy and immune dysfunction may limit the therapeutic options.Introdução: A psoríase ocorre em até 8% dos doentes com síndrome de Down e, embora mal caraterizada, parece estar correlacionada com desequilíbrio imunológico das células Th1e alterações bioquímicas nos nucleótidos cíclicos.Caso clínico: Doente do sexo feminino, 38 anos, com síndrome de Down e antecedentes de psoríase (PASI inicial de 30) desde os 18 anos de idade. Medicada com ciclosporina e metotrexato e subsequentemente foi medicada com etanercept, adalimumab e ustecinumab por perda progressiva de resposta (PASI atual de 10).Conclusão: Descreve-se este caso pela má resposta aos tratamentos, incluindo diversos agentes biológicos. A potencial baixa adesão à terapêutica e a disfunção imunológica poderão limitar as opções terapêuticas.Sociedade Portuguesa de Dermatologia e Venereologia2015-06-06T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.73.1.357oai:ojs.revista.spdv.com.pt:article/357Journal of the Portuguese Society of Dermatology and Venereology; Vol 73 No 1 (2015): Janeiro - Março; 147-150Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 73 n. 1 (2015): Janeiro - Março; 147-1502182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/357https://doi.org/10.29021/spdv.73.1.357https://revista.spdv.com.pt/index.php/spdv/article/view/357/326Araújo, CatarinaResende, CristinaVieira, Ana PaulaFernandes, José CarlosBrito, Celesteinfo:eu-repo/semantics/openAccess2022-10-06T12:34:52Zoai:ojs.revista.spdv.com.pt:article/357Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:52.078961Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
PSORÍASE EM PLACAS EM DOENTE COM SÍNDROME DE DOWN - POTENCIAL PATOFISIOLOGIA COMUM E DIFICULDADE DE TRATAMENTO
title PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
spellingShingle PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
Araújo, Catarina
Antibodies
monoclonal
Down syndrome
Psoriasis
Anticorpos monoclonais
Psoríase
Síndrome de Down
title_short PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
title_full PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
title_fullStr PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
title_full_unstemmed PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
title_sort PLAQUE PSORIASIS IN A PATIENT WITH DOWN SYNDROME - POTENTIAL COMMON PATHOPHYSIOLOGY AND TREATMENT DIFFICULTY
author Araújo, Catarina
author_facet Araújo, Catarina
Resende, Cristina
Vieira, Ana Paula
Fernandes, José Carlos
Brito, Celeste
author_role author
author2 Resende, Cristina
Vieira, Ana Paula
Fernandes, José Carlos
Brito, Celeste
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Catarina
Resende, Cristina
Vieira, Ana Paula
Fernandes, José Carlos
Brito, Celeste
dc.subject.por.fl_str_mv Antibodies
monoclonal
Down syndrome
Psoriasis
Anticorpos monoclonais
Psoríase
Síndrome de Down
topic Antibodies
monoclonal
Down syndrome
Psoriasis
Anticorpos monoclonais
Psoríase
Síndrome de Down
description Introduction: Psoriasis occurs in up to 8% of patients with Down syndrome and, although poorly characterized, appears to be correlated with immune imbalance in cells Th1 and biochemical changes of cyclic nucleotides.Case report: Female patient, 38 years old, with Down syndrome and psoriasis (initial PASI 30) since 18 years. Initially treated with cyclosporine and methotrexate and subsequently with etanercept, adalimumab and ustecinumab because of progressive loss of response (current PASI 10).Conclusion: We describe this case for the poor response to treatment including various biological agents. Potential poor adherence to therapy and immune dysfunction may limit the therapeutic options.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-06T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.73.1.357
oai:ojs.revista.spdv.com.pt:article/357
url https://doi.org/10.29021/spdv.73.1.357
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/357
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/357
https://doi.org/10.29021/spdv.73.1.357
https://revista.spdv.com.pt/index.php/spdv/article/view/357/326
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 73 No 1 (2015): Janeiro - Março; 147-150
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 73 n. 1 (2015): Janeiro - Março; 147-150
2182-2409
2182-2395
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130565044076544

Registros relacionados