Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/30520 |
Resumo: | Mammary tumors’ development was induced through the intraperioneal administration of the carcinogen N-methyl-N-nitrosourea (MNU). Animals from group control were injected with the vehicle (saline solution). Animals were sacrificed at 25 weeks-old and the organs were histopathologically evaluated. A higher number of lesions was observed in the organs of animals from group MNU. The animals from group control did not present any lesion in lymph nodes. Independently of the experimental group, the internal organs presented hemodynamic alterations, degenerative and inflammatory changes. Hemodynamic changes may be consequence of euthanasia method. As expected, the higher number and the higher grade of the lesions in group MNU were due to the carcinogen administration. |
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7160 |
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Histopathological features of organs in a rat model of mammary carcinogenesis: a reference databasehistologicalN-methyl-N-nitrosourearat modelrodentMammary tumors’ development was induced through the intraperioneal administration of the carcinogen N-methyl-N-nitrosourea (MNU). Animals from group control were injected with the vehicle (saline solution). Animals were sacrificed at 25 weeks-old and the organs were histopathologically evaluated. A higher number of lesions was observed in the organs of animals from group MNU. The animals from group control did not present any lesion in lymph nodes. Independently of the experimental group, the internal organs presented hemodynamic alterations, degenerative and inflammatory changes. Hemodynamic changes may be consequence of euthanasia method. As expected, the higher number and the higher grade of the lesions in group MNU were due to the carcinogen administration.REDVET - Revista Electrónica de Veterinaria2021-12-20T15:46:45Z2021-12-202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/30520http://hdl.handle.net/10174/30520porVala H, Vasconcelos-Nóbrega C, Gama A, Ferreira R, Oliveira PA, Faustino-Rocha AI. 2020. Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database. REDVET - Revista Electrónica de Veterinaria 21(4): 12-24.12-241695-7504http://veterinaria.org/index.php/REDVET/article/view/91214ndndndndndanafaustino@uevora.pt386Helena, ValaVasconcelos-Nóbrega, CarmenGama, AdelinaFerreira, RitaOliveira, Paula AlexandraFaustino-Rocha, Ana Isabelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:27:36Zoai:dspace.uevora.pt:10174/30520Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:19:33.833828Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
title |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
spellingShingle |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database Helena, Vala histological N-methyl-N-nitrosourea rat model rodent |
title_short |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
title_full |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
title_fullStr |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
title_full_unstemmed |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
title_sort |
Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database |
author |
Helena, Vala |
author_facet |
Helena, Vala Vasconcelos-Nóbrega, Carmen Gama, Adelina Ferreira, Rita Oliveira, Paula Alexandra Faustino-Rocha, Ana Isabel |
author_role |
author |
author2 |
Vasconcelos-Nóbrega, Carmen Gama, Adelina Ferreira, Rita Oliveira, Paula Alexandra Faustino-Rocha, Ana Isabel |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Helena, Vala Vasconcelos-Nóbrega, Carmen Gama, Adelina Ferreira, Rita Oliveira, Paula Alexandra Faustino-Rocha, Ana Isabel |
dc.subject.por.fl_str_mv |
histological N-methyl-N-nitrosourea rat model rodent |
topic |
histological N-methyl-N-nitrosourea rat model rodent |
description |
Mammary tumors’ development was induced through the intraperioneal administration of the carcinogen N-methyl-N-nitrosourea (MNU). Animals from group control were injected with the vehicle (saline solution). Animals were sacrificed at 25 weeks-old and the organs were histopathologically evaluated. A higher number of lesions was observed in the organs of animals from group MNU. The animals from group control did not present any lesion in lymph nodes. Independently of the experimental group, the internal organs presented hemodynamic alterations, degenerative and inflammatory changes. Hemodynamic changes may be consequence of euthanasia method. As expected, the higher number and the higher grade of the lesions in group MNU were due to the carcinogen administration. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01T00:00:00Z 2021-12-20T15:46:45Z 2021-12-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/30520 http://hdl.handle.net/10174/30520 |
url |
http://hdl.handle.net/10174/30520 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Vala H, Vasconcelos-Nóbrega C, Gama A, Ferreira R, Oliveira PA, Faustino-Rocha AI. 2020. Histopathological features of organs in a rat model of mammary carcinogenesis: a reference database. REDVET - Revista Electrónica de Veterinaria 21(4): 12-24. 12-24 1695-7504 http://veterinaria.org/index.php/REDVET/article/view/91 21 4 nd nd nd nd nd anafaustino@uevora.pt 386 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
REDVET - Revista Electrónica de Veterinaria |
publisher.none.fl_str_mv |
REDVET - Revista Electrónica de Veterinaria |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136677066702848 |