Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

Detalhes bibliográficos
Autor(a) principal: Martins, Sandra
Data de Publicação: 2016
Outros Autores: Amorim, Ricardo Luís Agra de, Pereira, Marta Sofia Carvalho Ribeiro Viana, Pinheiro, Céline, Silva, Patrícia, Couto, Carla, Alves, Sara, Fernandes, Sara, Preto, Ana, Reis, R. M., Longatto Filho, Adhemar, Baltazar, Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/45072
Resumo: Background: Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cases, lymph node and hepatic metastasis. Methods: Expressions of MCT1, MCT4, CD147 and GLUT1 were studied in human samples of CRC, lymph node and hepatic metastasis, by immunohistochemistry. Results: All proteins were overexpressed in primary CRC, lymph node and hepatic metastasis, when compared with non-neoplastic tissue, with exception of MCT1 in lymph node and hepatic metastasis. MCT1 and MCT4 expressions were associated with CD147 and GLUT1 in primary CRC. These markers were associated with clinical pathological features, reflecting the putative role of these metabolism-related proteins in the CRC setting. Conclusion: These findings provide additional evidence for the pivotal role of MCTs in CRC maintenance and progression, and support the use of MCTs as biomarkers and potential therapeutic targets in primary and metastatic CRC.
id RCAP_eea0727d61a06a0d5e71a9e53df19968
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/45072
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasisColorectal cancerLymph node metastasisHepatic metastasisMonocarboxylate transportersCD147GLUT1Colorectal cancer, Lymph node metastasis, Hepatic metastasis, Monocarboxylate transporters, CD147Science & TechnologyBackground: Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cases, lymph node and hepatic metastasis. Methods: Expressions of MCT1, MCT4, CD147 and GLUT1 were studied in human samples of CRC, lymph node and hepatic metastasis, by immunohistochemistry. Results: All proteins were overexpressed in primary CRC, lymph node and hepatic metastasis, when compared with non-neoplastic tissue, with exception of MCT1 in lymph node and hepatic metastasis. MCT1 and MCT4 expressions were associated with CD147 and GLUT1 in primary CRC. These markers were associated with clinical pathological features, reflecting the putative role of these metabolism-related proteins in the CRC setting. Conclusion: These findings provide additional evidence for the pivotal role of MCTs in CRC maintenance and progression, and support the use of MCTs as biomarkers and potential therapeutic targets in primary and metastatic CRC.This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) grant ref. PTDC/SAU-FCF/104347/2008, under the scope of ‘Programa Operacional Temático Factores de Competitividade’ (COMPETE) of ‘Quadro Comunitário de Apoio III’ and co-financed by the Fundo Europeu De Desenvolvimento Regional (FEDER). Ricardo Amorim was recipient of the fellowship SFRH/BD/98002/2013, from Fundação para a Ciência e a Tecnologia (FCT Portugal).info:eu-repo/semantics/publishedVersionBioMed Central (BMC)[et al.]Universidade do MinhoMartins, SandraAmorim, Ricardo Luís Agra dePereira, Marta Sofia Carvalho Ribeiro VianaPinheiro, CélineSilva, PatríciaCouto, CarlaAlves, SaraFernandes, SaraPreto, AnaReis, R. M.Longatto Filho, AdhemarBaltazar, Fátima20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/45072eng1471-240710.1186/s12885-016-2566-927460659https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962413/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T05:04:24Zoai:repositorium.sdum.uminho.pt:1822/45072Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T05:04:24Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
title Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
spellingShingle Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
Martins, Sandra
Colorectal cancer
Lymph node metastasis
Hepatic metastasis
Monocarboxylate transporters
CD147
GLUT1
Colorectal cancer, Lymph node metastasis, Hepatic metastasis, Monocarboxylate transporters, CD147
Science & Technology
title_short Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
title_full Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
title_fullStr Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
title_full_unstemmed Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
title_sort Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
author Martins, Sandra
author_facet Martins, Sandra
Amorim, Ricardo Luís Agra de
Pereira, Marta Sofia Carvalho Ribeiro Viana
Pinheiro, Céline
Silva, Patrícia
Couto, Carla
Alves, Sara
Fernandes, Sara
Preto, Ana
Reis, R. M.
Longatto Filho, Adhemar
Baltazar, Fátima
author_role author
author2 Amorim, Ricardo Luís Agra de
Pereira, Marta Sofia Carvalho Ribeiro Viana
Pinheiro, Céline
Silva, Patrícia
Couto, Carla
Alves, Sara
Fernandes, Sara
Preto, Ana
Reis, R. M.
Longatto Filho, Adhemar
Baltazar, Fátima
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv [et al.]
Universidade do Minho
dc.contributor.author.fl_str_mv Martins, Sandra
Amorim, Ricardo Luís Agra de
Pereira, Marta Sofia Carvalho Ribeiro Viana
Pinheiro, Céline
Silva, Patrícia
Couto, Carla
Alves, Sara
Fernandes, Sara
Preto, Ana
Reis, R. M.
Longatto Filho, Adhemar
Baltazar, Fátima
dc.subject.por.fl_str_mv Colorectal cancer
Lymph node metastasis
Hepatic metastasis
Monocarboxylate transporters
CD147
GLUT1
Colorectal cancer, Lymph node metastasis, Hepatic metastasis, Monocarboxylate transporters, CD147
Science & Technology
topic Colorectal cancer
Lymph node metastasis
Hepatic metastasis
Monocarboxylate transporters
CD147
GLUT1
Colorectal cancer, Lymph node metastasis, Hepatic metastasis, Monocarboxylate transporters, CD147
Science & Technology
description Background: Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cases, lymph node and hepatic metastasis. Methods: Expressions of MCT1, MCT4, CD147 and GLUT1 were studied in human samples of CRC, lymph node and hepatic metastasis, by immunohistochemistry. Results: All proteins were overexpressed in primary CRC, lymph node and hepatic metastasis, when compared with non-neoplastic tissue, with exception of MCT1 in lymph node and hepatic metastasis. MCT1 and MCT4 expressions were associated with CD147 and GLUT1 in primary CRC. These markers were associated with clinical pathological features, reflecting the putative role of these metabolism-related proteins in the CRC setting. Conclusion: These findings provide additional evidence for the pivotal role of MCTs in CRC maintenance and progression, and support the use of MCTs as biomarkers and potential therapeutic targets in primary and metastatic CRC.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/45072
url http://hdl.handle.net/1822/45072
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2407
10.1186/s12885-016-2566-9
27460659
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962413/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817544506963132416

Registros relacionados