CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34635/rpc.806 |
Resumo: | In the context of cancer, liquid biopsy refers to the capture and subsequent analysis of tumour material, such as circulating tumour cells (CTCs), circulating tumour nucleic acids and tumour-derived extracellular vesicles, present in the blood of patients with cancer, or even in other body fluids. CTCs are shed from primary tumours or metastatic sites and have a short half-life in circulation, therefore providing information about the biology of cancer in real time and holding great potential as a biomarker for cancer diagnosis, management, and prognosis. As a result, several technologies have been developed over the years in order to efficiently capture these cells with the ultimate goal of revolutionizing cancer assessment. A great focus is deserved on microfluidic-based approaches for CTC isolation, as they provide unprecedented sensitivity and purity, while keeping low cost. In this article, we discuss the huge impact that CTCs could have in oncology and ultimately in precision medicine regarding its greatest advantages against other circulating biomarkers, but we also consider its main limitations and current challenges to be implemented into the clinic. |
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CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINECÉLULAS TUMORAIS CIRCULANTES: CONTRIBUIÇÃO PORTUGUESA PARA A MEDICINA DE PRECISÃOIn the context of cancer, liquid biopsy refers to the capture and subsequent analysis of tumour material, such as circulating tumour cells (CTCs), circulating tumour nucleic acids and tumour-derived extracellular vesicles, present in the blood of patients with cancer, or even in other body fluids. CTCs are shed from primary tumours or metastatic sites and have a short half-life in circulation, therefore providing information about the biology of cancer in real time and holding great potential as a biomarker for cancer diagnosis, management, and prognosis. As a result, several technologies have been developed over the years in order to efficiently capture these cells with the ultimate goal of revolutionizing cancer assessment. A great focus is deserved on microfluidic-based approaches for CTC isolation, as they provide unprecedented sensitivity and purity, while keeping low cost. In this article, we discuss the huge impact that CTCs could have in oncology and ultimately in precision medicine regarding its greatest advantages against other circulating biomarkers, but we also consider its main limitations and current challenges to be implemented into the clinic.No contexto do cancro, a biopsia líquida é uma metodologia que se baseia na captura e análise de material de origem tumoral, tal como células tumorais circulantes (CTCs), ácidos nucleicos e vesiculas extracelulares, que se encontram em circulação no sangue de doentes com cancro, ou até mesmo noutros fluídos corporais. As CTCs são libertadas pelo tumor ou por lesões metastáticas, permitindo a obtenção de informação em tempo real sobre a biologia do cancro, conferindo-lhes um grande potencial para se tornarem biomarcadores úteis para o diagnóstico, gestão e prognóstico do cancro. Nos últimos anos, várias metodologias têm sido desenvolvidas com vista à captura eficiente destas células. Em particular as metodologias baseadas em microfluídica têm merecido especial atenção, uma vez que permitem obter elevada sensibilidade e pureza a baixo custo. Neste artigo, discutimos o grande impacto que as CTCs podem ter, não apenas na oncologia clínica, mas em última instância na medicina personalizada salientando as vantagens que as destacam comparativamente a outros biomarcadores circulantes. Temos, ainda, em consideração as suas principais limitações e atuais desafios à sua implementação na clínica.Sociedade Portuguesa de Cirurgia2020-07-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34635/rpc.806https://doi.org/10.34635/rpc.806Revista Portuguesa de Cirurgia; No 47 (2020): Number 47 - June 2020; 23-29Revista Portuguesa de Cirurgia; No 47 (2020): Number 47 - June 2020; 23-292183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spcir.com/index.php/spcir/article/view/806https://revista.spcir.com/index.php/spcir/article/view/806/543Copyright (c) 2020 Revista Portuguesa de Cirurgiainfo:eu-repo/semantics/openAccessCarneiro, AdrianaPiairo, PaulinaDiéguez, LorenaLima, Luís2024-03-14T22:04:55Zoai:revista.spcir.com:article/806Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:46.169126Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE CÉLULAS TUMORAIS CIRCULANTES: CONTRIBUIÇÃO PORTUGUESA PARA A MEDICINA DE PRECISÃO |
title |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE |
spellingShingle |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE Carneiro, Adriana |
title_short |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE |
title_full |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE |
title_fullStr |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE |
title_full_unstemmed |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE |
title_sort |
CIRCULATING TUMOUR CELLS: A PORTUGUESE CONTRIBUTION TOWARDS PRECISION MEDICINE |
author |
Carneiro, Adriana |
author_facet |
Carneiro, Adriana Piairo, Paulina Diéguez, Lorena Lima, Luís |
author_role |
author |
author2 |
Piairo, Paulina Diéguez, Lorena Lima, Luís |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Carneiro, Adriana Piairo, Paulina Diéguez, Lorena Lima, Luís |
description |
In the context of cancer, liquid biopsy refers to the capture and subsequent analysis of tumour material, such as circulating tumour cells (CTCs), circulating tumour nucleic acids and tumour-derived extracellular vesicles, present in the blood of patients with cancer, or even in other body fluids. CTCs are shed from primary tumours or metastatic sites and have a short half-life in circulation, therefore providing information about the biology of cancer in real time and holding great potential as a biomarker for cancer diagnosis, management, and prognosis. As a result, several technologies have been developed over the years in order to efficiently capture these cells with the ultimate goal of revolutionizing cancer assessment. A great focus is deserved on microfluidic-based approaches for CTC isolation, as they provide unprecedented sensitivity and purity, while keeping low cost. In this article, we discuss the huge impact that CTCs could have in oncology and ultimately in precision medicine regarding its greatest advantages against other circulating biomarkers, but we also consider its main limitations and current challenges to be implemented into the clinic. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34635/rpc.806 https://doi.org/10.34635/rpc.806 |
url |
https://doi.org/10.34635/rpc.806 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/806 https://revista.spcir.com/index.php/spcir/article/view/806/543 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista Portuguesa de Cirurgia info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista Portuguesa de Cirurgia |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
dc.source.none.fl_str_mv |
Revista Portuguesa de Cirurgia; No 47 (2020): Number 47 - June 2020; 23-29 Revista Portuguesa de Cirurgia; No 47 (2020): Number 47 - June 2020; 23-29 2183-1165 1646-6918 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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