Levofloxacin hepatotoxicity. Higher risk in diabetics?.

Detalhes bibliográficos
Autor(a) principal: Coelho, Joana
Data de Publicação: 2011
Outros Autores: Gonçalves, Carla, Leitão, Sara, Marques Dos Santos, R, Nascimento Costa, J
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529
Resumo: Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group.
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spelling Levofloxacin hepatotoxicity. Higher risk in diabetics?.Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos?Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group.Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group.Ordem dos Médicos2011-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529oai:ojs.www.actamedicaportuguesa.com:article/1529Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 729-34Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 729-341646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529/1114Coelho, JoanaGonçalves, CarlaLeitão, SaraMarques Dos Santos, RNascimento Costa, Jinfo:eu-repo/semantics/openAccess2022-12-20T10:58:02Zoai:ojs.www.actamedicaportuguesa.com:article/1529Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:12.656107Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Levofloxacin hepatotoxicity. Higher risk in diabetics?.
Hepatotoxicidade à levofloxacina. Risco aumentado em diabéticos?
title Levofloxacin hepatotoxicity. Higher risk in diabetics?.
spellingShingle Levofloxacin hepatotoxicity. Higher risk in diabetics?.
Coelho, Joana
title_short Levofloxacin hepatotoxicity. Higher risk in diabetics?.
title_full Levofloxacin hepatotoxicity. Higher risk in diabetics?.
title_fullStr Levofloxacin hepatotoxicity. Higher risk in diabetics?.
title_full_unstemmed Levofloxacin hepatotoxicity. Higher risk in diabetics?.
title_sort Levofloxacin hepatotoxicity. Higher risk in diabetics?.
author Coelho, Joana
author_facet Coelho, Joana
Gonçalves, Carla
Leitão, Sara
Marques Dos Santos, R
Nascimento Costa, J
author_role author
author2 Gonçalves, Carla
Leitão, Sara
Marques Dos Santos, R
Nascimento Costa, J
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Coelho, Joana
Gonçalves, Carla
Leitão, Sara
Marques Dos Santos, R
Nascimento Costa, J
description Levofloxacin, commonly used in medical practice, is prescribed to treat pneumonia in patients with comorbidities. Although generally well tolerated and safe, it has a well-known, but rarely reported, undercharacterized and ill-identified hepatotoxicity, with an unknown signature. With cases of fulminant hepatitis, cholestasis episodes reveal an apparently benign progression. Its capability of interference with the glucidic metabolism is also well-known, and the susceptibility factors to these events include age, presence of multiple pathologies and polymedication. The link between Diabetes Mellitus and hepatotoxicity has not yet been identified. Nonetheless, reports of several cases in literature along with the identification of two cases in insulin-treated diabetics, lead to believe that this is a higher-risk group.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-30
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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oai:ojs.www.actamedicaportuguesa.com:article/1529
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/1529
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1529/1114
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 729-34
Acta Médica Portuguesa; Vol. 24 (2011): Suplemento 3; 729-34
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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