Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study

Detalhes bibliográficos
Autor(a) principal: Amaral, André
Data de Publicação: 2009
Outros Autores: Cymbron, Teresa, Gärtner, Fátima, Lima, Manuela, Rodrigues, Armindo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/1366
Resumo: © 2009 Amaral et al; licensee BioMed Central Ltd.
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spelling Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control studyCancerMetallothioneinsMetalsBladderBovine© 2009 Amaral et al; licensee BioMed Central Ltd.Background: Previous studies have provided some evidence of a possible association between cancer and metallothioneins. Whether this relates to an exposure to carcinogenic metals remains unclear. Methods: In order to examine the association between the expression of metallothioneins and bladder tumors, and to compare the levels of arsenic, cadmium, chromium, lead and nickel in animals with bladder tumors and animals without bladder tumors, 37 cases of bovine bladder tumors and 17 controls were collected. The detection and quantification of metallothioneins in bladder tissue of both cases and controls was performed by immunohistochemistry. And the quantification of metals in tissue and hair was assessed by inductively coupled plasma – mass spectrometry. Results: Increased expression of metallothioneins was associated with bladder tumors when compared with non-tumoral bladder tissue (OR = 9.3, 95% CI: 1.0 – 480). The concentrations of cadmium, chromium, lead and nickel in hair of cases were significantly higher than those of controls. However, as for the concentration of metals in bladder tissue, the differences were not significant. Conclusion: Though the sample size was small, the present study shows an association between bladder tumors and metallothioneins. Moreover, it shows that concentrations of metals such as cadmium, chromium, lead and nickel in hair may be used as a biomarker of exposure.National Cancer Research Centre, CIRN, PHERG, IBMC, IPATIMUP.BioMed CentralRepositório da Universidade dos AçoresAmaral, AndréCymbron, TeresaGärtner, FátimaLima, ManuelaRodrigues, Armindo2012-05-24T15:44:34Z2009-07-182009-07-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/1366eng"BMC Veterinary Research". ISSN 1746-6148. Volume 5, Issue 24 (2009), 6 pp..1746-614810.1186/1746-6148-5-24info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:29:03Zoai:repositorio.uac.pt:10400.3/1366Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:24:12.875599Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
title Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
spellingShingle Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
Amaral, André
Cancer
Metallothioneins
Metals
Bladder
Bovine
title_short Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
title_full Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
title_fullStr Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
title_full_unstemmed Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
title_sort Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
author Amaral, André
author_facet Amaral, André
Cymbron, Teresa
Gärtner, Fátima
Lima, Manuela
Rodrigues, Armindo
author_role author
author2 Cymbron, Teresa
Gärtner, Fátima
Lima, Manuela
Rodrigues, Armindo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Amaral, André
Cymbron, Teresa
Gärtner, Fátima
Lima, Manuela
Rodrigues, Armindo
dc.subject.por.fl_str_mv Cancer
Metallothioneins
Metals
Bladder
Bovine
topic Cancer
Metallothioneins
Metals
Bladder
Bovine
description © 2009 Amaral et al; licensee BioMed Central Ltd.
publishDate 2009
dc.date.none.fl_str_mv 2009-07-18
2009-07-18T00:00:00Z
2012-05-24T15:44:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/1366
url http://hdl.handle.net/10400.3/1366
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "BMC Veterinary Research". ISSN 1746-6148. Volume 5, Issue 24 (2009), 6 pp..
1746-6148
10.1186/1746-6148-5-24
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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