PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes

Detalhes bibliográficos
Autor(a) principal: Silva, Stephane Edgar da
Data de Publicação: 2014
Outros Autores: Saraiva, Sofia M, Miguel, Sónia P., Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4664
Resumo: Fungal infections affecting human beings have increased during the last years and the currently available treatments, when administered for long periods, trigger microbial resistance. Such demands the development of new viable therapeutic alternatives. Silver is known since the antiquity by its antimicrobial properties and, herein, it was used to produce two types of nanoparticles (NPs), uncoated and coated with polyvinylpyrrolidone (PVP), which were aimed to be used in fungal infection treatment. NPs properties were characterized by Transmission electron microscopy, X-ray diffraction, UV–Vis, Dynamic light scattering, Fourier transform infrared, and Energy-dispersive X-ray spectroscopy. Furthermore, in vitro studies were also performed to evaluate NPs cytotoxic profile and antifungal activity. The results obtained revealed that the produced nanoparticles are biocompatible and have a good potential for being used in the treatment of common skin infections caused by Trichophyton rubrum and Trichophyton mentagrophytes, being PVP-coated silver NPs the most suitable ones.
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spelling PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytesBiocompatibilitySilver nanoparticlesFungal infectionsPolyvinylpyrrolidoneFungal infections affecting human beings have increased during the last years and the currently available treatments, when administered for long periods, trigger microbial resistance. Such demands the development of new viable therapeutic alternatives. Silver is known since the antiquity by its antimicrobial properties and, herein, it was used to produce two types of nanoparticles (NPs), uncoated and coated with polyvinylpyrrolidone (PVP), which were aimed to be used in fungal infection treatment. NPs properties were characterized by Transmission electron microscopy, X-ray diffraction, UV–Vis, Dynamic light scattering, Fourier transform infrared, and Energy-dispersive X-ray spectroscopy. Furthermore, in vitro studies were also performed to evaluate NPs cytotoxic profile and antifungal activity. The results obtained revealed that the produced nanoparticles are biocompatible and have a good potential for being used in the treatment of common skin infections caused by Trichophyton rubrum and Trichophyton mentagrophytes, being PVP-coated silver NPs the most suitable ones.SpringeruBibliorumSilva, Stephane Edgar daSaraiva, Sofia MMiguel, Sónia P.Correia, Ilídio Joaquim Sobreira2018-03-20T15:07:51Z2014-11-052014-11-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4664engSilva, E., Saraiva, S., Miguel, S.P. e Correia, I.J. (2014) “PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes”, Journal of Nanoparticle Research, Vol. 16:272610.1007/s11051-014-2726-2metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T12:15:04Zoai:ubibliorum.ubi.pt:10400.6/4664Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T12:15:04Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
title PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
spellingShingle PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
Silva, Stephane Edgar da
Biocompatibility
Silver nanoparticles
Fungal infections
Polyvinylpyrrolidone
title_short PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
title_full PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
title_fullStr PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
title_full_unstemmed PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
title_sort PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes
author Silva, Stephane Edgar da
author_facet Silva, Stephane Edgar da
Saraiva, Sofia M
Miguel, Sónia P.
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Saraiva, Sofia M
Miguel, Sónia P.
Correia, Ilídio Joaquim Sobreira
author2_role author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Silva, Stephane Edgar da
Saraiva, Sofia M
Miguel, Sónia P.
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv Biocompatibility
Silver nanoparticles
Fungal infections
Polyvinylpyrrolidone
topic Biocompatibility
Silver nanoparticles
Fungal infections
Polyvinylpyrrolidone
description Fungal infections affecting human beings have increased during the last years and the currently available treatments, when administered for long periods, trigger microbial resistance. Such demands the development of new viable therapeutic alternatives. Silver is known since the antiquity by its antimicrobial properties and, herein, it was used to produce two types of nanoparticles (NPs), uncoated and coated with polyvinylpyrrolidone (PVP), which were aimed to be used in fungal infection treatment. NPs properties were characterized by Transmission electron microscopy, X-ray diffraction, UV–Vis, Dynamic light scattering, Fourier transform infrared, and Energy-dispersive X-ray spectroscopy. Furthermore, in vitro studies were also performed to evaluate NPs cytotoxic profile and antifungal activity. The results obtained revealed that the produced nanoparticles are biocompatible and have a good potential for being used in the treatment of common skin infections caused by Trichophyton rubrum and Trichophyton mentagrophytes, being PVP-coated silver NPs the most suitable ones.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-05
2014-11-05T00:00:00Z
2018-03-20T15:07:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4664
url http://hdl.handle.net/10400.6/4664
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, E., Saraiva, S., Miguel, S.P. e Correia, I.J. (2014) “PVP-coated silver nanoparticles showing antifungal improved activity against dermatophytes”, Journal of Nanoparticle Research, Vol. 16:2726
10.1007/s11051-014-2726-2
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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