Effect of chlorhexidine incorporation on acrylic reline resins : release studies

Detalhes bibliográficos
Autor(a) principal: Marcelino, Neuza Isabel Fernandes
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/25530
Resumo: Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2015
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spelling Effect of chlorhexidine incorporation on acrylic reline resins : release studiesPróteseDoenças da mucosa oralCandidiaseEstomatitesTeses de mestrado - 2015Domínio/Área Científica::Ciências Médicas::Medicina ClínicaTese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2015The use of drug carriers and controlled-release agents are a promising strategy to treat denture stomatitis, since it has been claimed that they maintain ideal therapeutic levels of the drug at the site of infection. Chlorhexidine incorporation into denture acrylic resins has shown good results, both on releasing and microbiological tests. The main purpose of this study is to evaluate the release of chlorhexidine from acrylic reline resins, specifically the effect of different materials composition and drug loading on the drug release, with artificial saliva as media solution. Three different materials were evaluated in the present study, Kooliner, Ufi Gel Hard and Probase Cold. For each one, one control group and five experimental groups, incorporated with chlorhexidine 1%, 2.5%, 5%, 7.5% and 10% (w/w), were produced. A total of 54 cylinder-shaped specimens were evaluated. The cylinders were stored individually in graduated falcon tubes and covered with saliva at pH=7. The falcons were then placed into an incubator and, at specific time intervals, an aliquot were collected from each falcon and the same amount of artificial saliva was renovated, in order to simulate the constant salivary renovation. The samples were analyzed by UVspectroscopy and the chlorhexidine content was determined. The results showed that a high initial release was followed by a slower and steadier elution, during the entire study period. Besides it was demonstrated that the greatest amount of chlorhexidine release occurred within the first 24-48h of incubation, the results also showed that the release of chlorhexidine is affected by different materials composition, since that, for all chlorhexidine %, Ufi Gel Hard released the highest amount of chlorhexidine. It was also established that the release of chlorhexidine is drug loading-dependant. In addition, it was shown that the maximum cumulative release was 1.77%, so only a small amount of initial loaded chlorhexidine is liberated. However, all the materials, even with lower chlorhexidine % (1% w/w), presented a cumulative concentration of chlorhexidine superior than its MIC values. Overall, the results indicate that chlorhexidine delivery systems based on acrylic reline resins are a potential approach in the treatment of denture stomatitis.Neves, Maria Cristina Bettencourt, 1976-Bettencourt, Ana FranciscaRepositório da Universidade de LisboaMarcelino, Neuza Isabel Fernandes2016-12-29T11:28:00Z201520152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/25530TID:201272997enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:15:05Zoai:repositorio.ul.pt:10451/25530Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:42:24.757068Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of chlorhexidine incorporation on acrylic reline resins : release studies
title Effect of chlorhexidine incorporation on acrylic reline resins : release studies
spellingShingle Effect of chlorhexidine incorporation on acrylic reline resins : release studies
Marcelino, Neuza Isabel Fernandes
Prótese
Doenças da mucosa oral
Candidiase
Estomatites
Teses de mestrado - 2015
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
title_short Effect of chlorhexidine incorporation on acrylic reline resins : release studies
title_full Effect of chlorhexidine incorporation on acrylic reline resins : release studies
title_fullStr Effect of chlorhexidine incorporation on acrylic reline resins : release studies
title_full_unstemmed Effect of chlorhexidine incorporation on acrylic reline resins : release studies
title_sort Effect of chlorhexidine incorporation on acrylic reline resins : release studies
author Marcelino, Neuza Isabel Fernandes
author_facet Marcelino, Neuza Isabel Fernandes
author_role author
dc.contributor.none.fl_str_mv Neves, Maria Cristina Bettencourt, 1976-
Bettencourt, Ana Francisca
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Marcelino, Neuza Isabel Fernandes
dc.subject.por.fl_str_mv Prótese
Doenças da mucosa oral
Candidiase
Estomatites
Teses de mestrado - 2015
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
topic Prótese
Doenças da mucosa oral
Candidiase
Estomatites
Teses de mestrado - 2015
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
description Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2015
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015-01-01T00:00:00Z
2016-12-29T11:28:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/25530
TID:201272997
url http://hdl.handle.net/10451/25530
identifier_str_mv TID:201272997
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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