Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxK |
Resumo: | Background: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying antirheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents. Objectives: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic diseases first published in 2009. Methods: The first Portuguese guidelines for the use of MTX in rheumatic diseases were published in 2009 and were integrated in the multinational 3E Initiative (Evi - dence Expertise Exchange) project. The Portuguese rheumatologists based on literature evidence and consensus opinion formulated 13 recommendations. At a national meeting, the recommendations included in this document were further discussed and updated. The document resulting from this meeting circulated to all Portuguese rheumatologists, who anonymously voted online on the level of agreement with the updated recommendations. Results: Results presented in this article are mainly in accordance with previous guidelines, with some new information regarding hepatitis B infection during MTX treatment, pulmonary toxicity monitoring, hepatotoxi - city management, association with hematologic neoplasms, combination therapy and tuberculosis scree - ning during treatment. Conclusion: The present recommendations combine scientific evidence with expert opinion and attained desirable agreement among Portuguese rheumatologists. The regular update of these recommendations is essen - tial in order to keep them a valid and useful tool in daily practice. |
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Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 updateMethotrexatePortugalRecommendationsRheumatic diseasesRheumatoid arthritisRheumatologySDG 3 - Good Health and Well-beingBackground: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying antirheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents. Objectives: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic diseases first published in 2009. Methods: The first Portuguese guidelines for the use of MTX in rheumatic diseases were published in 2009 and were integrated in the multinational 3E Initiative (Evi - dence Expertise Exchange) project. The Portuguese rheumatologists based on literature evidence and consensus opinion formulated 13 recommendations. At a national meeting, the recommendations included in this document were further discussed and updated. The document resulting from this meeting circulated to all Portuguese rheumatologists, who anonymously voted online on the level of agreement with the updated recommendations. Results: Results presented in this article are mainly in accordance with previous guidelines, with some new information regarding hepatitis B infection during MTX treatment, pulmonary toxicity monitoring, hepatotoxi - city management, association with hematologic neoplasms, combination therapy and tuberculosis scree - ning during treatment. Conclusion: The present recommendations combine scientific evidence with expert opinion and attained desirable agreement among Portuguese rheumatologists. The regular update of these recommendations is essen - tial in order to keep them a valid and useful tool in daily practice.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNDuarte, Ana CatarinaSantos-Faria, D.Gonçalves, M. J.Sepriano, AlexandreMourão, A. F.Duarte, C.Neves, J. S.Águeda, A. F.Ribeiro, P. A.Daniel, A.Neto, A.Cordeiro, Ana CristinaRodrigues, A.Barcelos, A.Silva, C.Ponte, C.Vieira-Sousa, E.Teixeira, F.Oliveira-Ramos, F.Araújo, F.Barcelos, F.Canhão, HelenaSantos, H.Ramos, J.Polido-Pereira, J.Tavares-Costa, J.Melo Gomes, J. A.Cunha-Miranda, L.Costa, L.Cerqueira, M.Cruz, M.Santos, M. J.Bernardes, M.Oliveira, P.Abreu, P.Figueira, R.Barros, R.Falcão, S.Pinto, P.Pimenta, S.Capela, S.Teixeira, V.Fonseca, J. E.on behalf of Portuguese Society of Rheumatology2018-03-15T23:18:54Z2018-022018-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxKeng0303-464XPURE: 3694262http://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxKinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:18:09Zoai:run.unl.pt:10362/32620Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:29:54.967624Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
title |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
spellingShingle |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update Duarte, Ana Catarina Methotrexate Portugal Recommendations Rheumatic diseases Rheumatoid arthritis Rheumatology SDG 3 - Good Health and Well-being |
title_short |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
title_full |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
title_fullStr |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
title_full_unstemmed |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
title_sort |
Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update |
author |
Duarte, Ana Catarina |
author_facet |
Duarte, Ana Catarina Santos-Faria, D. Gonçalves, M. J. Sepriano, Alexandre Mourão, A. F. Duarte, C. Neves, J. S. Águeda, A. F. Ribeiro, P. A. Daniel, A. Neto, A. Cordeiro, Ana Cristina Rodrigues, A. Barcelos, A. Silva, C. Ponte, C. Vieira-Sousa, E. Teixeira, F. Oliveira-Ramos, F. Araújo, F. Barcelos, F. Canhão, Helena Santos, H. Ramos, J. Polido-Pereira, J. Tavares-Costa, J. Melo Gomes, J. A. Cunha-Miranda, L. Costa, L. Cerqueira, M. Cruz, M. Santos, M. J. Bernardes, M. Oliveira, P. Abreu, P. Figueira, R. Barros, R. Falcão, S. Pinto, P. Pimenta, S. Capela, S. Teixeira, V. Fonseca, J. E. on behalf of Portuguese Society of Rheumatology |
author_role |
author |
author2 |
Santos-Faria, D. Gonçalves, M. J. Sepriano, Alexandre Mourão, A. F. Duarte, C. Neves, J. S. Águeda, A. F. Ribeiro, P. A. Daniel, A. Neto, A. Cordeiro, Ana Cristina Rodrigues, A. Barcelos, A. Silva, C. Ponte, C. Vieira-Sousa, E. Teixeira, F. Oliveira-Ramos, F. Araújo, F. Barcelos, F. Canhão, Helena Santos, H. Ramos, J. Polido-Pereira, J. Tavares-Costa, J. Melo Gomes, J. A. Cunha-Miranda, L. Costa, L. Cerqueira, M. Cruz, M. Santos, M. J. Bernardes, M. Oliveira, P. Abreu, P. Figueira, R. Barros, R. Falcão, S. Pinto, P. Pimenta, S. Capela, S. Teixeira, V. Fonseca, J. E. on behalf of Portuguese Society of Rheumatology |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Duarte, Ana Catarina Santos-Faria, D. Gonçalves, M. J. Sepriano, Alexandre Mourão, A. F. Duarte, C. Neves, J. S. Águeda, A. F. Ribeiro, P. A. Daniel, A. Neto, A. Cordeiro, Ana Cristina Rodrigues, A. Barcelos, A. Silva, C. Ponte, C. Vieira-Sousa, E. Teixeira, F. Oliveira-Ramos, F. Araújo, F. Barcelos, F. Canhão, Helena Santos, H. Ramos, J. Polido-Pereira, J. Tavares-Costa, J. Melo Gomes, J. A. Cunha-Miranda, L. Costa, L. Cerqueira, M. Cruz, M. Santos, M. J. Bernardes, M. Oliveira, P. Abreu, P. Figueira, R. Barros, R. Falcão, S. Pinto, P. Pimenta, S. Capela, S. Teixeira, V. Fonseca, J. E. on behalf of Portuguese Society of Rheumatology |
dc.subject.por.fl_str_mv |
Methotrexate Portugal Recommendations Rheumatic diseases Rheumatoid arthritis Rheumatology SDG 3 - Good Health and Well-being |
topic |
Methotrexate Portugal Recommendations Rheumatic diseases Rheumatoid arthritis Rheumatology SDG 3 - Good Health and Well-being |
description |
Background: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying antirheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents. Objectives: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic diseases first published in 2009. Methods: The first Portuguese guidelines for the use of MTX in rheumatic diseases were published in 2009 and were integrated in the multinational 3E Initiative (Evi - dence Expertise Exchange) project. The Portuguese rheumatologists based on literature evidence and consensus opinion formulated 13 recommendations. At a national meeting, the recommendations included in this document were further discussed and updated. The document resulting from this meeting circulated to all Portuguese rheumatologists, who anonymously voted online on the level of agreement with the updated recommendations. Results: Results presented in this article are mainly in accordance with previous guidelines, with some new information regarding hepatitis B infection during MTX treatment, pulmonary toxicity monitoring, hepatotoxi - city management, association with hematologic neoplasms, combination therapy and tuberculosis scree - ning during treatment. Conclusion: The present recommendations combine scientific evidence with expert opinion and attained desirable agreement among Portuguese rheumatologists. The regular update of these recommendations is essen - tial in order to keep them a valid and useful tool in daily practice. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-15T23:18:54Z 2018-02 2018-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
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http://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxK |
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http://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxK |
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eng |
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eng |
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0303-464X PURE: 3694262 http://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxK |
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info:eu-repo/semantics/openAccess |
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14 application/pdf |
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