Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections

Detalhes bibliográficos
Autor(a) principal: Pires, Diana
Data de Publicação: 2015
Outros Autores: Boas, Diana Patrícia Andrade Vilas, Sillankorva, Sanna, Azeredo, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38734
Resumo: Antimicrobial resistance constitutes one of the major worldwide public health concerns. Bacteria are becoming resistant to the vast majority of antibiotics and nowadays, a common infection can be fatal. To revert this situation, the use of phages for the treatment of bacterial infections has been extensively studied as an alternative therapeutic strategy. Since P. aeruginosa is one of the most common causes of healthcare-associated infections, many studies have reported the in vitro and in vivo antibacterial efficacy of phage therapy against this bacterium. This review collects data of all the P. aeruginosa phages sequenced to date, providing a better understanding about their biodiversity. This review will further address the in vitro and in vivo results obtained by using phages to treat or prevent P. aeruginosa infections as well as the major hurdles associated with this therapy.
id RCAP_f05a243ee08419f59d42966743fb4667
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/38734
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infectionsScience & TechnologyAntimicrobial resistance constitutes one of the major worldwide public health concerns. Bacteria are becoming resistant to the vast majority of antibiotics and nowadays, a common infection can be fatal. To revert this situation, the use of phages for the treatment of bacterial infections has been extensively studied as an alternative therapeutic strategy. Since P. aeruginosa is one of the most common causes of healthcare-associated infections, many studies have reported the in vitro and in vivo antibacterial efficacy of phage therapy against this bacterium. This review collects data of all the P. aeruginosa phages sequenced to date, providing a better understanding about their biodiversity. This review will further address the in vitro and in vivo results obtained by using phages to treat or prevent P. aeruginosa infections as well as the major hurdles associated with this therapy.D.P.P. acknowledges financial support from the Portuguese Foundation for Science and Technology (FCT) (grant SFRH/BD/76440/2011). S.S. is an FCT investigator (IF/01413/2013).The authors also thank FCT for the Strategic Project of the UID/BIO/04469/2013 unit, FCT and the European Union (FEDER/COMPETE) for funds for the RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) project, and the “BioHealth-Biotechnology and Bioengineering approaches to improve health quality” (NORTE-07-0124-FEDER-000027) project, cofunded by the Programa OperaciAmerican Society for Microbiology (ASM)Universidade do MinhoPires, DianaBoas, Diana Patrícia Andrade VilasSillankorva, SannaAzeredo, Joana20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38734engPires, Diana; Vilas Boas, Diana; Sillankorva, Sanna; Azeredo, Joana, Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections. Journal of Virology, 89(15), 7449-7456, 20150022-538X1098-551410.1128/JVI.00385-1525972556info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:50Zoai:repositorium.sdum.uminho.pt:1822/38734Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:19.439927Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
title Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
spellingShingle Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
Pires, Diana
Science & Technology
title_short Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
title_full Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
title_fullStr Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
title_full_unstemmed Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
title_sort Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections
author Pires, Diana
author_facet Pires, Diana
Boas, Diana Patrícia Andrade Vilas
Sillankorva, Sanna
Azeredo, Joana
author_role author
author2 Boas, Diana Patrícia Andrade Vilas
Sillankorva, Sanna
Azeredo, Joana
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pires, Diana
Boas, Diana Patrícia Andrade Vilas
Sillankorva, Sanna
Azeredo, Joana
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Antimicrobial resistance constitutes one of the major worldwide public health concerns. Bacteria are becoming resistant to the vast majority of antibiotics and nowadays, a common infection can be fatal. To revert this situation, the use of phages for the treatment of bacterial infections has been extensively studied as an alternative therapeutic strategy. Since P. aeruginosa is one of the most common causes of healthcare-associated infections, many studies have reported the in vitro and in vivo antibacterial efficacy of phage therapy against this bacterium. This review collects data of all the P. aeruginosa phages sequenced to date, providing a better understanding about their biodiversity. This review will further address the in vitro and in vivo results obtained by using phages to treat or prevent P. aeruginosa infections as well as the major hurdles associated with this therapy.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38734
url http://hdl.handle.net/1822/38734
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pires, Diana; Vilas Boas, Diana; Sillankorva, Sanna; Azeredo, Joana, Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections. Journal of Virology, 89(15), 7449-7456, 2015
0022-538X
1098-5514
10.1128/JVI.00385-15
25972556
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology (ASM)
publisher.none.fl_str_mv American Society for Microbiology (ASM)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132679689469952

Registros relacionados