Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Detalhes bibliográficos
Autor(a) principal: Parente Carvalho, Catia
Data de Publicação: 2015
Outros Autores: Norouzy, Amir, Ribeiro, Vera, Nau, Werner M., Pischel, Uwe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/11632
Resumo: Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.
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spelling Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleasesMolecular ContainersAmino-AcidsSynthetic ReceptorMass-SpectrometryPk(A) ShiftsPeptidesBindingRecognitionDrugsThermodynamicsCucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.Spanish MINECO [CTQ2011-28390]; FEDER; COST [CM1005]; DFG [NA-686/5]; Portuguese FCT [SFRH/BD/81628/2011, PEst-OE/EQB/LA0023/2013]Royal Soc ChemistrySapientiaParente Carvalho, CatiaNorouzy, AmirRibeiro, VeraNau, Werner M.Pischel, Uwe2018-12-07T14:53:40Z2015-032015-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11632eng1477-052010.1039/c4ob02122cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:28Zoai:sapientia.ualg.pt:10400.1/11632Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:06.772577Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
title Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
spellingShingle Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
Parente Carvalho, Catia
Molecular Containers
Amino-Acids
Synthetic Receptor
Mass-Spectrometry
Pk(A) Shifts
Peptides
Binding
Recognition
Drugs
Thermodynamics
title_short Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
title_full Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
title_fullStr Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
title_full_unstemmed Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
title_sort Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases
author Parente Carvalho, Catia
author_facet Parente Carvalho, Catia
Norouzy, Amir
Ribeiro, Vera
Nau, Werner M.
Pischel, Uwe
author_role author
author2 Norouzy, Amir
Ribeiro, Vera
Nau, Werner M.
Pischel, Uwe
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Parente Carvalho, Catia
Norouzy, Amir
Ribeiro, Vera
Nau, Werner M.
Pischel, Uwe
dc.subject.por.fl_str_mv Molecular Containers
Amino-Acids
Synthetic Receptor
Mass-Spectrometry
Pk(A) Shifts
Peptides
Binding
Recognition
Drugs
Thermodynamics
topic Molecular Containers
Amino-Acids
Synthetic Receptor
Mass-Spectrometry
Pk(A) Shifts
Peptides
Binding
Recognition
Drugs
Thermodynamics
description Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
2015-03-01T00:00:00Z
2018-12-07T14:53:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/11632
url http://hdl.handle.net/10400.1/11632
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1477-0520
10.1039/c4ob02122c
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Soc Chemistry
publisher.none.fl_str_mv Royal Soc Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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