MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109767 https://doi.org/10.3390/ph6101195 |
Resumo: | The discovery of small RNA molecules with the capacity to regulate messenger RNA (mRNA) stability and translation (and consequently protein synthesis) has revealed an additional level of post-transcriptional gene control. MicroRNAs (miRNAs), an evolutionarily conserved class of small noncoding RNAs that regulate gene expression post-transcriptionally by base pairing to complementary sequences in the 3' untranslated regions of target mRNAs, are part of this modulatory RNA network playing a pivotal role in cell fate. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway, while changes in miRNA expression are associated with several human pathologies, including cancer. By targeting oncogenes and tumor suppressors, miRNAs have the ability to modulate key cellular processes that define the cell phenotype, making them highly promising therapeutic targets. Over the last few years, miRNA-based anti-cancer therapeutic approaches have been exploited, either alone or in combination with standard targeted therapies, aiming at enhancing tumor cell killing and, ideally, promoting tumor regression and disease remission. Here we provide an overview on the involvement of miRNAs in cancer pathology, emphasizing the mechanisms of miRNA regulation. Strategies for modulating miRNA expression are presented and illustrated with representative examples of their application in a therapeutic context. |
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MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA ExpressionmicroRNA (miRNA)anti-miRNA oligonucleotidesmiRNA mimicscancer therapyviral and non-viral carriersThe discovery of small RNA molecules with the capacity to regulate messenger RNA (mRNA) stability and translation (and consequently protein synthesis) has revealed an additional level of post-transcriptional gene control. MicroRNAs (miRNAs), an evolutionarily conserved class of small noncoding RNAs that regulate gene expression post-transcriptionally by base pairing to complementary sequences in the 3' untranslated regions of target mRNAs, are part of this modulatory RNA network playing a pivotal role in cell fate. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway, while changes in miRNA expression are associated with several human pathologies, including cancer. By targeting oncogenes and tumor suppressors, miRNAs have the ability to modulate key cellular processes that define the cell phenotype, making them highly promising therapeutic targets. Over the last few years, miRNA-based anti-cancer therapeutic approaches have been exploited, either alone or in combination with standard targeted therapies, aiming at enhancing tumor cell killing and, ideally, promoting tumor regression and disease remission. Here we provide an overview on the involvement of miRNAs in cancer pathology, emphasizing the mechanisms of miRNA regulation. Strategies for modulating miRNA expression are presented and illustrated with representative examples of their application in a therapeutic context.MDPI2013-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109767http://hdl.handle.net/10316/109767https://doi.org/10.3390/ph6101195eng1424-8247Costa, Pedro M.Lima, M. C. Pedroso deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-26T07:57:53Zoai:estudogeral.uc.pt:10316/109767Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:54.886628Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
title |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
spellingShingle |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression Costa, Pedro M. microRNA (miRNA) anti-miRNA oligonucleotides miRNA mimics cancer therapy viral and non-viral carriers |
title_short |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
title_full |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
title_fullStr |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
title_full_unstemmed |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
title_sort |
MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression |
author |
Costa, Pedro M. |
author_facet |
Costa, Pedro M. Lima, M. C. Pedroso de |
author_role |
author |
author2 |
Lima, M. C. Pedroso de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Costa, Pedro M. Lima, M. C. Pedroso de |
dc.subject.por.fl_str_mv |
microRNA (miRNA) anti-miRNA oligonucleotides miRNA mimics cancer therapy viral and non-viral carriers |
topic |
microRNA (miRNA) anti-miRNA oligonucleotides miRNA mimics cancer therapy viral and non-viral carriers |
description |
The discovery of small RNA molecules with the capacity to regulate messenger RNA (mRNA) stability and translation (and consequently protein synthesis) has revealed an additional level of post-transcriptional gene control. MicroRNAs (miRNAs), an evolutionarily conserved class of small noncoding RNAs that regulate gene expression post-transcriptionally by base pairing to complementary sequences in the 3' untranslated regions of target mRNAs, are part of this modulatory RNA network playing a pivotal role in cell fate. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway, while changes in miRNA expression are associated with several human pathologies, including cancer. By targeting oncogenes and tumor suppressors, miRNAs have the ability to modulate key cellular processes that define the cell phenotype, making them highly promising therapeutic targets. Over the last few years, miRNA-based anti-cancer therapeutic approaches have been exploited, either alone or in combination with standard targeted therapies, aiming at enhancing tumor cell killing and, ideally, promoting tumor regression and disease remission. Here we provide an overview on the involvement of miRNAs in cancer pathology, emphasizing the mechanisms of miRNA regulation. Strategies for modulating miRNA expression are presented and illustrated with representative examples of their application in a therapeutic context. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109767 http://hdl.handle.net/10316/109767 https://doi.org/10.3390/ph6101195 |
url |
http://hdl.handle.net/10316/109767 https://doi.org/10.3390/ph6101195 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1424-8247 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134140842377216 |