Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Detalhes bibliográficos
Autor(a) principal: Rocha, Cheila
Data de Publicação: 2017
Outros Autores: Duarte, Joana, Borrego, Pedro, Calado, Rita, Marcelino, José Maria, Tendeiro, Rita, Valadas, Emília, Sousa, Ana Espada, Taveira, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/30469
Resumo: Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
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spelling Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cellsHIV-2 antibodiesMemory B cellsPotent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.Wolters KluwerRepositório ComumRocha, CheilaDuarte, JoanaBorrego, PedroCalado, RitaMarcelino, José MariaTendeiro, RitaValadas, EmíliaSousa, Ana EspadaTaveira, Nuno2019-12-12T16:08:57Z2017-11-01T00:00:00Z2017-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30469engAIDS: November 13, 2017 - Volume 31 - Issue 17 - p 2431–2433. doi: 10.1097/QAD.00000000000016610269-937010.1097/QAD.0000000000001661info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:51Zoai:comum.rcaap.pt:10400.26/30469Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:37.915726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
title Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
spellingShingle Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
Rocha, Cheila
HIV-2 antibodies
Memory B cells
title_short Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
title_full Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
title_fullStr Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
title_full_unstemmed Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
title_sort Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
author Rocha, Cheila
author_facet Rocha, Cheila
Duarte, Joana
Borrego, Pedro
Calado, Rita
Marcelino, José Maria
Tendeiro, Rita
Valadas, Emília
Sousa, Ana Espada
Taveira, Nuno
author_role author
author2 Duarte, Joana
Borrego, Pedro
Calado, Rita
Marcelino, José Maria
Tendeiro, Rita
Valadas, Emília
Sousa, Ana Espada
Taveira, Nuno
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Rocha, Cheila
Duarte, Joana
Borrego, Pedro
Calado, Rita
Marcelino, José Maria
Tendeiro, Rita
Valadas, Emília
Sousa, Ana Espada
Taveira, Nuno
dc.subject.por.fl_str_mv HIV-2 antibodies
Memory B cells
topic HIV-2 antibodies
Memory B cells
description Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-01T00:00:00Z
2017-11-01T00:00:00Z
2019-12-12T16:08:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30469
url http://hdl.handle.net/10400.26/30469
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIDS: November 13, 2017 - Volume 31 - Issue 17 - p 2431–2433. doi: 10.1097/QAD.0000000000001661
0269-9370
10.1097/QAD.0000000000001661
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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