Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana
Data de Publicação: 2018
Outros Autores: Ferraz, Ricardo, Ficker, Lauren, Collins, Margaret S., Prudêncio, Cristina, Cushion, Melanie T., Teixeira, Cátia, Gomes, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14183
Resumo: The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
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spelling Chloroquine Analogues as Leads against Pneumocystis Lung PathogensPneumocystischloroquineImmunosuppressedLung infectionMalariaPneumoniaThe impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.American Society for MicrobiologyRepositório Científico do Instituto Politécnico do PortoGomes, AnaFerraz, RicardoFicker, LaurenCollins, Margaret S.Prudêncio, CristinaCushion, Melanie T.Teixeira, CátiaGomes, Paula2019-07-01T12:42:42Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14183engGomes, A., Ferraz, R., Ficker, L., Collins, M. S., Prudêncio, C., Cushion, M. T., Teixeira, C., & Gomes, P. (2018). Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial Agents and Chemotherapy, 62(11), 10.1128/aac.00983-18. https://doi.org/10.1128/aac.00983-1810.1128/AAC.00983-18info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:05Zoai:recipp.ipp.pt:10400.22/14183Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:00.225458Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
title Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
spellingShingle Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
Gomes, Ana
Pneumocystis
chloroquine
Immunosuppressed
Lung infection
Malaria
Pneumonia
title_short Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
title_full Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
title_fullStr Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
title_full_unstemmed Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
title_sort Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens
author Gomes, Ana
author_facet Gomes, Ana
Ferraz, Ricardo
Ficker, Lauren
Collins, Margaret S.
Prudêncio, Cristina
Cushion, Melanie T.
Teixeira, Cátia
Gomes, Paula
author_role author
author2 Ferraz, Ricardo
Ficker, Lauren
Collins, Margaret S.
Prudêncio, Cristina
Cushion, Melanie T.
Teixeira, Cátia
Gomes, Paula
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Gomes, Ana
Ferraz, Ricardo
Ficker, Lauren
Collins, Margaret S.
Prudêncio, Cristina
Cushion, Melanie T.
Teixeira, Cátia
Gomes, Paula
dc.subject.por.fl_str_mv Pneumocystis
chloroquine
Immunosuppressed
Lung infection
Malaria
Pneumonia
topic Pneumocystis
chloroquine
Immunosuppressed
Lung infection
Malaria
Pneumonia
description The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-07-01T12:42:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14183
url http://hdl.handle.net/10400.22/14183
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes, A., Ferraz, R., Ficker, L., Collins, M. S., Prudêncio, C., Cushion, M. T., Teixeira, C., & Gomes, P. (2018). Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial Agents and Chemotherapy, 62(11), 10.1128/aac.00983-18. https://doi.org/10.1128/aac.00983-18
10.1128/AAC.00983-18
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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