The importance of protein sources to support muscle anabolism in cancer: an expert group opinion
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/36244 |
Resumo: | This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emphasis on the supposed non-beneficial effect of proteins; therefore, misconceptions involving animal-based (e.g., meat, fish, dairy) and plant-based (e.g., legumes) proteins in cancer are acknowledged and addressed. Although the optimal dietary amino acid composition to support muscle health in cancer is yet to be established, animal-based proteins have a composition that offers superior anabolic potential, compared to plant-derived proteins. Thus, animal-based foods should represent the majority (i.e., ≥65%) of protein intake during active cancer treatment. A diet rich in plant-derived proteins may support muscle anabolism in cancer, albeit requiring a larger quantity of protein to fulfill the optimal amino acid intake. We caution that translating dietary recommendations for cancer prevention to cancer treatment may be inadequate to support the pro-inflammatory and catabolic nature of the disease. We further caution against initiating an exclusively plant-based (i.e., vegan) diet upon a diagnosis of cancer, given the presence of elevated protein requirements and risk of inadequate protein intake to support muscle anabolism. Amino acid combination and the long-term sustainability of a dietary pattern void of animal-based foods requires careful and laborious management of protein intake for patients with cancer. Ultimately, a dietary amino acid composition that promotes muscle anabolism is optimally obtained through combination of animal- and plant-based protein sources. |
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The importance of protein sources to support muscle anabolism in cancer: an expert group opinionAnabolismAnimal proteinCancerMusclePlant proteinProtein sourceThis opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emphasis on the supposed non-beneficial effect of proteins; therefore, misconceptions involving animal-based (e.g., meat, fish, dairy) and plant-based (e.g., legumes) proteins in cancer are acknowledged and addressed. Although the optimal dietary amino acid composition to support muscle health in cancer is yet to be established, animal-based proteins have a composition that offers superior anabolic potential, compared to plant-derived proteins. Thus, animal-based foods should represent the majority (i.e., ≥65%) of protein intake during active cancer treatment. A diet rich in plant-derived proteins may support muscle anabolism in cancer, albeit requiring a larger quantity of protein to fulfill the optimal amino acid intake. We caution that translating dietary recommendations for cancer prevention to cancer treatment may be inadequate to support the pro-inflammatory and catabolic nature of the disease. We further caution against initiating an exclusively plant-based (i.e., vegan) diet upon a diagnosis of cancer, given the presence of elevated protein requirements and risk of inadequate protein intake to support muscle anabolism. Amino acid combination and the long-term sustainability of a dietary pattern void of animal-based foods requires careful and laborious management of protein intake for patients with cancer. Ultimately, a dietary amino acid composition that promotes muscle anabolism is optimally obtained through combination of animal- and plant-based protein sources.Veritati - Repositório Institucional da Universidade Católica PortuguesaFord, Katherine L.Arends, JannAtherton, Philip J.Engelen, Mariëlle P. K. J.Gonçalves, Thiago J. M.Laviano, AlessandroLobo, Dileep N.Phillips, Stuart M.Ravasco, PaulaDeutz, Nicolaas E. P.Prado, Carla M.2021-12-22T13:49:50Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/36244eng0261-561410.1016/j.clnu.2021.11.0328512081169934891022000740706900020info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-23T01:41:24Zoai:repositorio.ucp.pt:10400.14/36244Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:29:25.979389Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
title |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
spellingShingle |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion Ford, Katherine L. Anabolism Animal protein Cancer Muscle Plant protein Protein source |
title_short |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
title_full |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
title_fullStr |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
title_full_unstemmed |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
title_sort |
The importance of protein sources to support muscle anabolism in cancer: an expert group opinion |
author |
Ford, Katherine L. |
author_facet |
Ford, Katherine L. Arends, Jann Atherton, Philip J. Engelen, Mariëlle P. K. J. Gonçalves, Thiago J. M. Laviano, Alessandro Lobo, Dileep N. Phillips, Stuart M. Ravasco, Paula Deutz, Nicolaas E. P. Prado, Carla M. |
author_role |
author |
author2 |
Arends, Jann Atherton, Philip J. Engelen, Mariëlle P. K. J. Gonçalves, Thiago J. M. Laviano, Alessandro Lobo, Dileep N. Phillips, Stuart M. Ravasco, Paula Deutz, Nicolaas E. P. Prado, Carla M. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Ford, Katherine L. Arends, Jann Atherton, Philip J. Engelen, Mariëlle P. K. J. Gonçalves, Thiago J. M. Laviano, Alessandro Lobo, Dileep N. Phillips, Stuart M. Ravasco, Paula Deutz, Nicolaas E. P. Prado, Carla M. |
dc.subject.por.fl_str_mv |
Anabolism Animal protein Cancer Muscle Plant protein Protein source |
topic |
Anabolism Animal protein Cancer Muscle Plant protein Protein source |
description |
This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emphasis on the supposed non-beneficial effect of proteins; therefore, misconceptions involving animal-based (e.g., meat, fish, dairy) and plant-based (e.g., legumes) proteins in cancer are acknowledged and addressed. Although the optimal dietary amino acid composition to support muscle health in cancer is yet to be established, animal-based proteins have a composition that offers superior anabolic potential, compared to plant-derived proteins. Thus, animal-based foods should represent the majority (i.e., ≥65%) of protein intake during active cancer treatment. A diet rich in plant-derived proteins may support muscle anabolism in cancer, albeit requiring a larger quantity of protein to fulfill the optimal amino acid intake. We caution that translating dietary recommendations for cancer prevention to cancer treatment may be inadequate to support the pro-inflammatory and catabolic nature of the disease. We further caution against initiating an exclusively plant-based (i.e., vegan) diet upon a diagnosis of cancer, given the presence of elevated protein requirements and risk of inadequate protein intake to support muscle anabolism. Amino acid combination and the long-term sustainability of a dietary pattern void of animal-based foods requires careful and laborious management of protein intake for patients with cancer. Ultimately, a dietary amino acid composition that promotes muscle anabolism is optimally obtained through combination of animal- and plant-based protein sources. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-22T13:49:50Z 2022-01 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/36244 |
url |
http://hdl.handle.net/10400.14/36244 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0261-5614 10.1016/j.clnu.2021.11.032 85120811699 34891022 000740706900020 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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