Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations

Detalhes bibliográficos
Autor(a) principal: Guimarães, Rafaela
Data de Publicação: 2013
Outros Autores: Barros, Lillian, Dueñas, Montserrat, Calhelha, Ricardo C., Carvalho, Ana Maria, Santos-Buelga, Celestino, Queiroz, Maria João R. P., Ferreira, Isabel C. F. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/63919
Resumo: Roman chamomile, Chamaemelum nobile L. (Asteraceae), has been used for medicinal applications, mainly through oral dosage forms (decoctions and infusions). Herein, the nutritional characterisation of C. nobile was performed, and herbal material and its decoction and infusion were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation, the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture. C. nobile proved to be an equilibrated valuable herb rich in carbohydrates and proteins, and poor in fat, providing tocopherols, carotenoids and essential fatty acids (C18:2n6 and C18:3n3). Moreover, the herb and its infusion are a source of phenolic compounds (flavonoids such as flavonols and flavones, phenolic acids and derivatives) and organic acids (oxalic, quinic, malic, citric and fumaric acids) that showed antioxidant and antitumour activities, without hepatotoxicity. The most abundant compounds in the plant extract and infusion were 5-O-caffeoylquinic acid and an apigenin derivative. These, as well as other bioactive compounds, are affected in C. nobile decoction, leading to a lower antioxidant potential and absence of antitumour potential. The plant bioactivity could be explored in the medicine, food, and cosmetic industries.
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spelling Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparationsAnimalsAntineoplastic AgentsAntioxidantsCell Line, TumorChamaemelumHumansNutritive ValuePlant ExtractsSwineChamaemelum nobileRoman chamomileNutrientsPhenolic compoundsAntioxidant activityAntitumour potentialCiências Médicas::Biotecnologia MédicaScience & TechnologyRoman chamomile, Chamaemelum nobile L. (Asteraceae), has been used for medicinal applications, mainly through oral dosage forms (decoctions and infusions). Herein, the nutritional characterisation of C. nobile was performed, and herbal material and its decoction and infusion were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation, the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture. C. nobile proved to be an equilibrated valuable herb rich in carbohydrates and proteins, and poor in fat, providing tocopherols, carotenoids and essential fatty acids (C18:2n6 and C18:3n3). Moreover, the herb and its infusion are a source of phenolic compounds (flavonoids such as flavonols and flavones, phenolic acids and derivatives) and organic acids (oxalic, quinic, malic, citric and fumaric acids) that showed antioxidant and antitumour activities, without hepatotoxicity. The most abundant compounds in the plant extract and infusion were 5-O-caffeoylquinic acid and an apigenin derivative. These, as well as other bioactive compounds, are affected in C. nobile decoction, leading to a lower antioxidant potential and absence of antitumour potential. The plant bioactivity could be explored in the medicine, food, and cosmetic industries.The authors are grateful to strategic project PEst-OE/AGR/UI0690/2011 for financial support to CIMO. R. Guimaraes, L. Barros and R. Calhelha thanks to FCT, POPH-QREN and FSE for their Grants (SFRH/BD/78307/2011, SFRH/BPD/4609/2008 and SFRH/BPD/68344/2010). The GIP-USAL is financially supported by the Consolider-Ingenio 2010 Programme (FUN-C-FOOD, CSD2007-00063). M. Duenas thanks the Spanish "Ramon y Cajal" Programme for a contract.Elsevier Science LtdUniversidade do MinhoGuimarães, RafaelaBarros, LillianDueñas, MontserratCalhelha, Ricardo C.Carvalho, Ana MariaSantos-Buelga, CelestinoQueiroz, Maria João R. P.Ferreira, Isabel C. F. R.2013-01-152013-01-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63919engGuimarães, R., Barros, L., Dueñas, M., Calhelha, R. C., Carvalho, A. M., Santos-Buelga, C., ... & Ferreira, I. C. (2013). Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations. Food Chemistry, 136(2), 718-7250308-814610.1016/j.foodchem.2012.08.02523122119https://www.sciencedirect.com/science/article/pii/S030881461201309Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:30Zoai:repositorium.sdum.uminho.pt:1822/63919Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:29:02.594142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
title Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
spellingShingle Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
Guimarães, Rafaela
Animals
Antineoplastic Agents
Antioxidants
Cell Line, Tumor
Chamaemelum
Humans
Nutritive Value
Plant Extracts
Swine
Chamaemelum nobile
Roman chamomile
Nutrients
Phenolic compounds
Antioxidant activity
Antitumour potential
Ciências Médicas::Biotecnologia Médica
Science & Technology
title_short Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
title_full Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
title_fullStr Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
title_full_unstemmed Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
title_sort Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations
author Guimarães, Rafaela
author_facet Guimarães, Rafaela
Barros, Lillian
Dueñas, Montserrat
Calhelha, Ricardo C.
Carvalho, Ana Maria
Santos-Buelga, Celestino
Queiroz, Maria João R. P.
Ferreira, Isabel C. F. R.
author_role author
author2 Barros, Lillian
Dueñas, Montserrat
Calhelha, Ricardo C.
Carvalho, Ana Maria
Santos-Buelga, Celestino
Queiroz, Maria João R. P.
Ferreira, Isabel C. F. R.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Guimarães, Rafaela
Barros, Lillian
Dueñas, Montserrat
Calhelha, Ricardo C.
Carvalho, Ana Maria
Santos-Buelga, Celestino
Queiroz, Maria João R. P.
Ferreira, Isabel C. F. R.
dc.subject.por.fl_str_mv Animals
Antineoplastic Agents
Antioxidants
Cell Line, Tumor
Chamaemelum
Humans
Nutritive Value
Plant Extracts
Swine
Chamaemelum nobile
Roman chamomile
Nutrients
Phenolic compounds
Antioxidant activity
Antitumour potential
Ciências Médicas::Biotecnologia Médica
Science & Technology
topic Animals
Antineoplastic Agents
Antioxidants
Cell Line, Tumor
Chamaemelum
Humans
Nutritive Value
Plant Extracts
Swine
Chamaemelum nobile
Roman chamomile
Nutrients
Phenolic compounds
Antioxidant activity
Antitumour potential
Ciências Médicas::Biotecnologia Médica
Science & Technology
description Roman chamomile, Chamaemelum nobile L. (Asteraceae), has been used for medicinal applications, mainly through oral dosage forms (decoctions and infusions). Herein, the nutritional characterisation of C. nobile was performed, and herbal material and its decoction and infusion were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation, the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture. C. nobile proved to be an equilibrated valuable herb rich in carbohydrates and proteins, and poor in fat, providing tocopherols, carotenoids and essential fatty acids (C18:2n6 and C18:3n3). Moreover, the herb and its infusion are a source of phenolic compounds (flavonoids such as flavonols and flavones, phenolic acids and derivatives) and organic acids (oxalic, quinic, malic, citric and fumaric acids) that showed antioxidant and antitumour activities, without hepatotoxicity. The most abundant compounds in the plant extract and infusion were 5-O-caffeoylquinic acid and an apigenin derivative. These, as well as other bioactive compounds, are affected in C. nobile decoction, leading to a lower antioxidant potential and absence of antitumour potential. The plant bioactivity could be explored in the medicine, food, and cosmetic industries.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-15
2013-01-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/63919
url http://hdl.handle.net/1822/63919
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Guimarães, R., Barros, L., Dueñas, M., Calhelha, R. C., Carvalho, A. M., Santos-Buelga, C., ... & Ferreira, I. C. (2013). Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations. Food Chemistry, 136(2), 718-725
0308-8146
10.1016/j.foodchem.2012.08.025
23122119
https://www.sciencedirect.com/science/article/pii/S030881461201309X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Ltd
publisher.none.fl_str_mv Elsevier Science Ltd
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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