C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/57323 |
Resumo: | © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patientsHemodialysisInflammationMalnutritionMortality© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.Background: The first few months of hemodialysis (HD) are associated with a higher risk of mortality. Protein-energy malnutrition is a demonstrated major risk factor for mortality in this population. The C-Reactive Protein to Albumin ratio (CAR) has also been associated with increased mortality risk. The aim of this study was to determine the predictive value of CAR for six-month mortality in incident HD patients. Methods: Retrospective analysis of incident HD patients between January 2014 and December 2019. CAR was calculated at the start of HD. We analyzed six-month mortality. A Cox regression was performed to predict six-month mortality and the discriminatory ability of CAR was determined using the receiver operating characteristic (ROC) curve. Results: A total of 787 patients were analyzed (mean age 68.34 ± 15.5 years and 60.6% male). The 6-month mortality was 13.8% (n = 109). Patients who died were significantly older (p < 0.001), had more cardiovascular disease (p = 0.010), had central venous catheter at the start of HD (p < 0.001), lower parathyroid hormone (PTH) level (p = 0.014) and higher CAR (p = 0.015). The AUC for mortality prediction was 0.706 (95% CI (0.65-0.76), p < 0.001). The optimal CAR cutoff was ≥0.5, HR 5.36 (95% CI 3.21-8.96, p < 0.001). Conclusion: We demonstrated that higher CAR was significantly associated with a higher mortality risk in the first six months of HD, highlighting the prognostic importance of malnutrition and inflammation in patients starting chronic HD.Taylor & FrancisRepositório da Universidade de LisboaSant’Ana, MarianaGameiro, JoanaCosta, CláudiaBranco, CarolinaMarques Da Silva, BernardoPeres, NadiesdaCardoso, AnaAbrantes, Ana MafaldaFonseca, José AgapitoOuterelo, CristinaResina, CristinaLopes, José António2023-05-03T11:19:14Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57323engRen Fail. 2023 Dec;45(1):21826150886-022X10.1080/0886022X.2023.21826151525-6049info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:27Zoai:repositorio.ul.pt:10451/57323Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:43.778597Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| title |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| spellingShingle |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients Sant’Ana, Mariana Hemodialysis Inflammation Malnutrition Mortality |
| title_short |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| title_full |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| title_fullStr |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| title_full_unstemmed |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| title_sort |
C-reactive protein-to-albumin ratio and six-month mortality in incident hemodialysis patients |
| author |
Sant’Ana, Mariana |
| author_facet |
Sant’Ana, Mariana Gameiro, Joana Costa, Cláudia Branco, Carolina Marques Da Silva, Bernardo Peres, Nadiesda Cardoso, Ana Abrantes, Ana Mafalda Fonseca, José Agapito Outerelo, Cristina Resina, Cristina Lopes, José António |
| author_role |
author |
| author2 |
Gameiro, Joana Costa, Cláudia Branco, Carolina Marques Da Silva, Bernardo Peres, Nadiesda Cardoso, Ana Abrantes, Ana Mafalda Fonseca, José Agapito Outerelo, Cristina Resina, Cristina Lopes, José António |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Sant’Ana, Mariana Gameiro, Joana Costa, Cláudia Branco, Carolina Marques Da Silva, Bernardo Peres, Nadiesda Cardoso, Ana Abrantes, Ana Mafalda Fonseca, José Agapito Outerelo, Cristina Resina, Cristina Lopes, José António |
| dc.subject.por.fl_str_mv |
Hemodialysis Inflammation Malnutrition Mortality |
| topic |
Hemodialysis Inflammation Malnutrition Mortality |
| description |
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-05-03T11:19:14Z 2023 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/57323 |
| url |
http://hdl.handle.net/10451/57323 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ren Fail. 2023 Dec;45(1):2182615 0886-022X 10.1080/0886022X.2023.2182615 1525-6049 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Taylor & Francis |
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Taylor & Francis |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134630950993920 |