Citalopram administration does not promote function or histological recovery after spinal cord injury

Detalhes bibliográficos
Autor(a) principal: Lima, Rui
Data de Publicação: 2020
Outros Autores: Monteiro, Susana, Gomes, Eduardo Domingos Correia, Vasconcelos, Natália L., Assunção-Silva, Rita, Morais, Mónica, Salgado, A. J., Silva, Nuno André Martins
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/66192
Resumo: Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week citalopram treatment in a contusive spinal cord injury (SCI) rat model. A combination of behavioral tests, histological and serum cytokine analysis was used to assess overall recovery. Despite promoting a mild reduction of inflammatory cells as well as an early, but transient increase of specific serum cytokines, citalopram administration showed no overall beneficial effects on motor performance or lesion extension. Our results do not support citalopram treatment as a therapeutic strategy for SCI.
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spelling Citalopram administration does not promote function or histological recovery after spinal cord injuryspinal cord injurycitalopramSSRImotor recovery5-HTScience & TechnologyCitalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week citalopram treatment in a contusive spinal cord injury (SCI) rat model. A combination of behavioral tests, histological and serum cytokine analysis was used to assess overall recovery. Despite promoting a mild reduction of inflammatory cells as well as an early, but transient increase of specific serum cytokines, citalopram administration showed no overall beneficial effects on motor performance or lesion extension. Our results do not support citalopram treatment as a therapeutic strategy for SCI.This research was funded by Prémios Santa Casa Neurociências—Prize Melo e Castro for SpinalCord Injury Research, Grant Number MC-04/17 and the Portuguese Foundation for Science and Technology(FCT) through the Scientific Employment Stimulus to N. Silva and S. Monteiro (CEECIND/04794/2017 and CEECIND/01902/2017) and fellowships to RL (PD/BDE/127836/2016); EDG (SFRH/BD/103075/2014);NLV (SFRH/BD/136952/2018) and R.AS (PDE/BDE/113596/2015).This work was also funded by FEDER,through the Competitiveness Internalization Operational Program (POCI) and by National funds, throughthe Foundation for Sciences and Technology (FCT), under the scope of the projects POCI-01-0145-FEDER-007038,POCI-01-0145-FEDER-029206, POCI-01-0145-FEDER-029751 and PTDC/BTM-MAT/29968/2017. This work hasbeen funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI - PortuguesePlatform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122; by National funds, through the Foundationfor Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020; and by the projectsNORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Program (NORTE2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).Multidisciplinary Digital Publishing InstituteUniversidade do MinhoLima, RuiMonteiro, SusanaGomes, Eduardo Domingos CorreiaVasconcelos, Natália L.Assunção-Silva, RitaMorais, MónicaSalgado, A. J.Silva, Nuno André Martins20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/66192engLima, R.; Monteiro, S.; Gomes, E.D.; Vasconcelos, N.L.; Assunção-Silva, R.; Morais, M.; Salgado, A.J.; Silva, N.A. Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury. Int. J. Mol. Sci. 2020, 21, 5062.1661-65961422-006710.3390/ijms2114506232709070https://www.mdpi.com/1422-0067/21/14/5062info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:43:49Zoai:repositorium.sdum.uminho.pt:1822/66192Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:41:22.919432Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Citalopram administration does not promote function or histological recovery after spinal cord injury
title Citalopram administration does not promote function or histological recovery after spinal cord injury
spellingShingle Citalopram administration does not promote function or histological recovery after spinal cord injury
Lima, Rui
spinal cord injury
citalopram
SSRI
motor recovery
5-HT
Science & Technology
title_short Citalopram administration does not promote function or histological recovery after spinal cord injury
title_full Citalopram administration does not promote function or histological recovery after spinal cord injury
title_fullStr Citalopram administration does not promote function or histological recovery after spinal cord injury
title_full_unstemmed Citalopram administration does not promote function or histological recovery after spinal cord injury
title_sort Citalopram administration does not promote function or histological recovery after spinal cord injury
author Lima, Rui
author_facet Lima, Rui
Monteiro, Susana
Gomes, Eduardo Domingos Correia
Vasconcelos, Natália L.
Assunção-Silva, Rita
Morais, Mónica
Salgado, A. J.
Silva, Nuno André Martins
author_role author
author2 Monteiro, Susana
Gomes, Eduardo Domingos Correia
Vasconcelos, Natália L.
Assunção-Silva, Rita
Morais, Mónica
Salgado, A. J.
Silva, Nuno André Martins
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Lima, Rui
Monteiro, Susana
Gomes, Eduardo Domingos Correia
Vasconcelos, Natália L.
Assunção-Silva, Rita
Morais, Mónica
Salgado, A. J.
Silva, Nuno André Martins
dc.subject.por.fl_str_mv spinal cord injury
citalopram
SSRI
motor recovery
5-HT
Science & Technology
topic spinal cord injury
citalopram
SSRI
motor recovery
5-HT
Science & Technology
description Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week citalopram treatment in a contusive spinal cord injury (SCI) rat model. A combination of behavioral tests, histological and serum cytokine analysis was used to assess overall recovery. Despite promoting a mild reduction of inflammatory cells as well as an early, but transient increase of specific serum cytokines, citalopram administration showed no overall beneficial effects on motor performance or lesion extension. Our results do not support citalopram treatment as a therapeutic strategy for SCI.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/66192
url http://hdl.handle.net/1822/66192
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lima, R.; Monteiro, S.; Gomes, E.D.; Vasconcelos, N.L.; Assunção-Silva, R.; Morais, M.; Salgado, A.J.; Silva, N.A. Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury. Int. J. Mol. Sci. 2020, 21, 5062.
1661-6596
1422-0067
10.3390/ijms21145062
32709070
https://www.mdpi.com/1422-0067/21/14/5062
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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