Neudesin is involved in anxiety behavior: structural and neurochemical correlates
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/26978 |
Resumo: | Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry. |
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Neudesin is involved in anxiety behavior: structural and neurochemical correlatesNeudesinAnxietyDopamineVentral hippocampusBed nucleus of the stria terminalisScience & TechnologyNeudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.This work is supported by a grant from FCT (PTDC/SAU-OSM/104475/2008) under POCTI-COMPETE funds. Ashley Novais, Ana Catarina Ferreira, Ana David-Pereira and Filipa L. Campos are recipients of doctoral fellowships and Fernanda Marques is a recipient of postdoctoral fellowship from Fundacao para a Ciencia e Tecnologia (FCT), Portugal. We acknowledge Merck Serono for providing the neudesin-null mouse strain. We are thankful to Despina Papasava and Vasileios Kafetzopoulos for the assistance given in the HPLC analysis of neurotransmitters.Frontiers MediaUniversidade do MinhoNovais, Ashley CruzFerreira, Ana C.Marques, FernandaPêgo, José M.Cerqueira, JoãoPereira, Ana Carla DavidCampos, Filipa L.Dalla, ChristinaKokras, N.Sousa, NunoPalha, Joana AlmeidaSousa, João Carlos2013-092013-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/26978eng1662-515310.3389/fnbeh.2013.00119http://www.frontiersin.org/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:44:55Zoai:repositorium.sdum.uminho.pt:1822/26978Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:42:42.726438Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
title |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
spellingShingle |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates Novais, Ashley Cruz Neudesin Anxiety Dopamine Ventral hippocampus Bed nucleus of the stria terminalis Science & Technology |
title_short |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
title_full |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
title_fullStr |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
title_full_unstemmed |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
title_sort |
Neudesin is involved in anxiety behavior: structural and neurochemical correlates |
author |
Novais, Ashley Cruz |
author_facet |
Novais, Ashley Cruz Ferreira, Ana C. Marques, Fernanda Pêgo, José M. Cerqueira, João Pereira, Ana Carla David Campos, Filipa L. Dalla, Christina Kokras, N. Sousa, Nuno Palha, Joana Almeida Sousa, João Carlos |
author_role |
author |
author2 |
Ferreira, Ana C. Marques, Fernanda Pêgo, José M. Cerqueira, João Pereira, Ana Carla David Campos, Filipa L. Dalla, Christina Kokras, N. Sousa, Nuno Palha, Joana Almeida Sousa, João Carlos |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Novais, Ashley Cruz Ferreira, Ana C. Marques, Fernanda Pêgo, José M. Cerqueira, João Pereira, Ana Carla David Campos, Filipa L. Dalla, Christina Kokras, N. Sousa, Nuno Palha, Joana Almeida Sousa, João Carlos |
dc.subject.por.fl_str_mv |
Neudesin Anxiety Dopamine Ventral hippocampus Bed nucleus of the stria terminalis Science & Technology |
topic |
Neudesin Anxiety Dopamine Ventral hippocampus Bed nucleus of the stria terminalis Science & Technology |
description |
Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09 2013-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/26978 |
url |
http://hdl.handle.net/1822/26978 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-5153 10.3389/fnbeh.2013.00119 http://www.frontiersin.org/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132980871954432 |