Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors

Detalhes bibliográficos
Autor(a) principal: Bidinotto, Lucas Tadeu
Data de Publicação: 2018
Outros Autores: Véo, Carlos A. R., Loaiza, Edgar Aleman, Ribeiro, Guilherme G., Lorenzi, Adriana T., Rosa, Luciana Albina Reis, De Oliveira, Cristina Mendes, Levi, José Eduardo, Scapulatempo-Neto, Cristovam, Longatto, Adhemar, Reis, R. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58082
Resumo: There has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal. The resected tumors of 48 patients [8 high-grade intraepithelial lesions (HSILs), 14 adenocarcinomas and 26 squamous cell carcinomas (SCCs)] were immunohistochemically evaluated for RKIP expression, and the results were correlated with clinicopathological data. The results identified a decreased 5-year overall survival rate in patients with adenocarcinoma (40.8%) compared with patients with SCC (76.7%), and a decreased 5-year disease-free survival rate in patients at clinical stages III/IV (37.3 vs. 62.5 and 82.6% for clinical stages 0 and I/II, respectively). Low RKIP expression was revealed in 62.5% of HSILs, 88.5% of SCCs and 100.0% of the adenocarcinomas. High RKIP expression was associated with patient ethnicity (37.5% in non-Caucasians vs. 7.5% in Caucasians) and patient age (33.3% in younger patients vs. 0.0% in older patients). Finally, high RKIP expression was correlated with HPV16 infection status (40% in HPV- vs. 5.3% in HPV+ patients). A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation between high RKIP expression and HPV16 positivity in patients.
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spelling Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumorsAdenocarcinomaAnal cancerHigh-grade squamous intra-epithelial lesionRaf kinase inhibitor proteinSquamous-cell carcinomaCiências Médicas::Medicina BásicaScience & TechnologyThere has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal. The resected tumors of 48 patients [8 high-grade intraepithelial lesions (HSILs), 14 adenocarcinomas and 26 squamous cell carcinomas (SCCs)] were immunohistochemically evaluated for RKIP expression, and the results were correlated with clinicopathological data. The results identified a decreased 5-year overall survival rate in patients with adenocarcinoma (40.8%) compared with patients with SCC (76.7%), and a decreased 5-year disease-free survival rate in patients at clinical stages III/IV (37.3 vs. 62.5 and 82.6% for clinical stages 0 and I/II, respectively). Low RKIP expression was revealed in 62.5% of HSILs, 88.5% of SCCs and 100.0% of the adenocarcinomas. High RKIP expression was associated with patient ethnicity (37.5% in non-Caucasians vs. 7.5% in Caucasians) and patient age (33.3% in younger patients vs. 0.0% in older patients). Finally, high RKIP expression was correlated with HPV16 infection status (40% in HPV- vs. 5.3% in HPV+ patients). A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation between high RKIP expression and HPV16 positivity in patients.São Paulo Research Foundation (grant nos. 2010/16795-4 and 2011/08523-7) and Ministry of Science, Technology, Innovation and Communication (grant no. MCT/FINEP/CT-INFRA-PROINFRA 01/2011)info:eu-repo/semantics/publishedVersionSpandidos PublicationsUniversidade do MinhoBidinotto, Lucas TadeuVéo, Carlos A. R.Loaiza, Edgar AlemanRibeiro, Guilherme G.Lorenzi, Adriana T.Rosa, Luciana Albina ReisDe Oliveira, Cristina MendesLevi, José EduardoScapulatempo-Neto, CristovamLongatto, AdhemarReis, R. M.2018-082018-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58082engBidinotto, L. T., Véo, C. A., Loaiza, E. A., et. al. (2018). Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors. Oncology letters, 16(2), 1785-17901792-10741792-10810.3892/ol.2018.8828https://www.spandidos-publications.com/10.3892/ol.2018.8828info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:24Zoai:repositorium.sdum.uminho.pt:1822/58082Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:50:17.057745Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
title Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
spellingShingle Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
Bidinotto, Lucas Tadeu
Adenocarcinoma
Anal cancer
High-grade squamous intra-epithelial lesion
Raf kinase inhibitor protein
Squamous-cell carcinoma
Ciências Médicas::Medicina Básica
Science & Technology
title_short Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
title_full Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
title_fullStr Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
title_full_unstemmed Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
title_sort Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors
author Bidinotto, Lucas Tadeu
author_facet Bidinotto, Lucas Tadeu
Véo, Carlos A. R.
Loaiza, Edgar Aleman
Ribeiro, Guilherme G.
Lorenzi, Adriana T.
Rosa, Luciana Albina Reis
De Oliveira, Cristina Mendes
Levi, José Eduardo
Scapulatempo-Neto, Cristovam
Longatto, Adhemar
Reis, R. M.
author_role author
author2 Véo, Carlos A. R.
Loaiza, Edgar Aleman
Ribeiro, Guilherme G.
Lorenzi, Adriana T.
Rosa, Luciana Albina Reis
De Oliveira, Cristina Mendes
Levi, José Eduardo
Scapulatempo-Neto, Cristovam
Longatto, Adhemar
Reis, R. M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bidinotto, Lucas Tadeu
Véo, Carlos A. R.
Loaiza, Edgar Aleman
Ribeiro, Guilherme G.
Lorenzi, Adriana T.
Rosa, Luciana Albina Reis
De Oliveira, Cristina Mendes
Levi, José Eduardo
Scapulatempo-Neto, Cristovam
Longatto, Adhemar
Reis, R. M.
dc.subject.por.fl_str_mv Adenocarcinoma
Anal cancer
High-grade squamous intra-epithelial lesion
Raf kinase inhibitor protein
Squamous-cell carcinoma
Ciências Médicas::Medicina Básica
Science & Technology
topic Adenocarcinoma
Anal cancer
High-grade squamous intra-epithelial lesion
Raf kinase inhibitor protein
Squamous-cell carcinoma
Ciências Médicas::Medicina Básica
Science & Technology
description There has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal. The resected tumors of 48 patients [8 high-grade intraepithelial lesions (HSILs), 14 adenocarcinomas and 26 squamous cell carcinomas (SCCs)] were immunohistochemically evaluated for RKIP expression, and the results were correlated with clinicopathological data. The results identified a decreased 5-year overall survival rate in patients with adenocarcinoma (40.8%) compared with patients with SCC (76.7%), and a decreased 5-year disease-free survival rate in patients at clinical stages III/IV (37.3 vs. 62.5 and 82.6% for clinical stages 0 and I/II, respectively). Low RKIP expression was revealed in 62.5% of HSILs, 88.5% of SCCs and 100.0% of the adenocarcinomas. High RKIP expression was associated with patient ethnicity (37.5% in non-Caucasians vs. 7.5% in Caucasians) and patient age (33.3% in younger patients vs. 0.0% in older patients). Finally, high RKIP expression was correlated with HPV16 infection status (40% in HPV- vs. 5.3% in HPV+ patients). A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation between high RKIP expression and HPV16 positivity in patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
2018-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58082
url http://hdl.handle.net/1822/58082
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bidinotto, L. T., Véo, C. A., Loaiza, E. A., et. al. (2018). Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors. Oncology letters, 16(2), 1785-1790
1792-1074
1792-108
10.3892/ol.2018.8828
https://www.spandidos-publications.com/10.3892/ol.2018.8828
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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