Amyloidosis caused by {32 microglobulin in chronic renal failure

• Autor(a) principal: Grade, Maria José
• Data de Publicação: 1997
• Outros Autores: Nabais, Maria José, Ramos, Fátima, Negrão, Luís, Cabrita, António, Ralha, Emília, Cabral, Pires, de Moura, Pereira, Alexandrino, Borges, Serra e silva, Políbio
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/2226
• topic: hemodiálise; amiloidose {32 microglobulina; {32 microglobin amyloidosis; haemodialysis

The amyloidosis, caused by {32 microglobin ( {32M) is a complication of renal substitute therapy, parti­culary with long term haemodyalisis. {32M, the prece­ eding molecule of the amyloid fibrils, accumulates in renal failure dueto its reduced excretion; the amount of the referred accumulatwn seems to depend essen­ cially on the lengh of time of dialysis and the type of membranes used The authors have studed eleven patients subjected to regular haemodialysis, in order to discover the existence of amyloidosis caused by {32M. Resides the identification of the clinical signs of this entity, name­ly the osteoarticularsigns, of wich the most characte­ristic is the carpal tunnel syndrome. The authors sys­tematically biopsied the subcutaneous abdominal fat, made nerve conduction studies, echocardiography, bone x-rays and osteoarticular scintigraphy. The results are presented, comparing thepatients withthree or less years of haemodialysis with those who have been dialysed for more than eight years. Concerning the results, the authors highüght thefo­ llowing: 1) The presence of CTS in 4 patients (36;4 per cent);2) Cervical spondyloarthropathy was demons­ trated in 66, 7 per cent in long term haemodialysis patients; 3) The existence of cardiac amyloidosis in 20 per cent of patients; 4) The presence of Beta 2M amyloidosis in 3 patients (27,3 per cent) in profound skin biopsies.