Development of Flexible Bone Grafts
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/39804 |
Resumo: | With the aging of world’s population, diseases and bone related problems are becoming more frequent. Bone grafts are normally used in the treatment and repair of bone defects. The aim of this project was to develop a flexible bone graft in order to be adjustable to the patient's problem. The development of this product consisted in combining a natural protein, type I collagen, extracted from bovine tendon, with β-TCP, a calcium phosphate. The composition of this product was 10:90 wt%, respectively. Its production focused in a lyophilization cycle and posteriorly Dehydrothermal crosslinking, using three different treatments: 24, 48 and 72h. The products were characterized by XRD, FTIR, SEM, Archimedes Method, compression tests and TGA-DSC. All the composites manufactured showed a porous structure, revealing values in the range of 84 to 87%.The β-TCP particles were homogeneously distributed and overlapped in the collagen matrix. The crystalline phases of the samples were studied and the presence of β-TCP was identified. Molecular groups were identified as referring to collagen and β-TCP. The observed amide peaks I, II, III, A and B tend to be less pronounced when the crosslinking exposure time increases, while the phosphate groups were observed with clarity. The products exhibited Young's Modulus values ranging from 180 to 200 kPa. These values tend to increase when the exposure time of crosslinking increases. Mass losses were not considered significant for the crosslinked products, varying between 8 and 11%. However it was shown that the Dehydrothermal crosslinking minimizes mass losses when compared to composites without this treatment. It is possible to conclude that a flexible bone graft was successfully developed. For that reason, the collagen / β-TCP composite showed a better handling when compared to calcium phosphates bone grafts. |
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Development of Flexible Bone GraftsFlexible Bone GraftType I Bovine Tendon CollagenCalcium β-TriphosphateBiomaterial and CompositeDomínio/Área Científica::Engenharia e Tecnologia::Engenharia dos MateriaisWith the aging of world’s population, diseases and bone related problems are becoming more frequent. Bone grafts are normally used in the treatment and repair of bone defects. The aim of this project was to develop a flexible bone graft in order to be adjustable to the patient's problem. The development of this product consisted in combining a natural protein, type I collagen, extracted from bovine tendon, with β-TCP, a calcium phosphate. The composition of this product was 10:90 wt%, respectively. Its production focused in a lyophilization cycle and posteriorly Dehydrothermal crosslinking, using three different treatments: 24, 48 and 72h. The products were characterized by XRD, FTIR, SEM, Archimedes Method, compression tests and TGA-DSC. All the composites manufactured showed a porous structure, revealing values in the range of 84 to 87%.The β-TCP particles were homogeneously distributed and overlapped in the collagen matrix. The crystalline phases of the samples were studied and the presence of β-TCP was identified. Molecular groups were identified as referring to collagen and β-TCP. The observed amide peaks I, II, III, A and B tend to be less pronounced when the crosslinking exposure time increases, while the phosphate groups were observed with clarity. The products exhibited Young's Modulus values ranging from 180 to 200 kPa. These values tend to increase when the exposure time of crosslinking increases. Mass losses were not considered significant for the crosslinked products, varying between 8 and 11%. However it was shown that the Dehydrothermal crosslinking minimizes mass losses when compared to composites without this treatment. It is possible to conclude that a flexible bone graft was successfully developed. For that reason, the collagen / β-TCP composite showed a better handling when compared to calcium phosphates bone grafts.Ranito, CláudiaBorges, JoãoRUNGameiro, Rafael Capêlo Leite2021-03-26T01:30:20Z2018-05-0420182018-05-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/39804TID:202467996enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:21:16Zoai:run.unl.pt:10362/39804Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:31:01.311120Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of Flexible Bone Grafts |
title |
Development of Flexible Bone Grafts |
spellingShingle |
Development of Flexible Bone Grafts Gameiro, Rafael Capêlo Leite Flexible Bone Graft Type I Bovine Tendon Collagen Calcium β-Triphosphate Biomaterial and Composite Domínio/Área Científica::Engenharia e Tecnologia::Engenharia dos Materiais |
title_short |
Development of Flexible Bone Grafts |
title_full |
Development of Flexible Bone Grafts |
title_fullStr |
Development of Flexible Bone Grafts |
title_full_unstemmed |
Development of Flexible Bone Grafts |
title_sort |
Development of Flexible Bone Grafts |
author |
Gameiro, Rafael Capêlo Leite |
author_facet |
Gameiro, Rafael Capêlo Leite |
author_role |
author |
dc.contributor.none.fl_str_mv |
Ranito, Cláudia Borges, João RUN |
dc.contributor.author.fl_str_mv |
Gameiro, Rafael Capêlo Leite |
dc.subject.por.fl_str_mv |
Flexible Bone Graft Type I Bovine Tendon Collagen Calcium β-Triphosphate Biomaterial and Composite Domínio/Área Científica::Engenharia e Tecnologia::Engenharia dos Materiais |
topic |
Flexible Bone Graft Type I Bovine Tendon Collagen Calcium β-Triphosphate Biomaterial and Composite Domínio/Área Científica::Engenharia e Tecnologia::Engenharia dos Materiais |
description |
With the aging of world’s population, diseases and bone related problems are becoming more frequent. Bone grafts are normally used in the treatment and repair of bone defects. The aim of this project was to develop a flexible bone graft in order to be adjustable to the patient's problem. The development of this product consisted in combining a natural protein, type I collagen, extracted from bovine tendon, with β-TCP, a calcium phosphate. The composition of this product was 10:90 wt%, respectively. Its production focused in a lyophilization cycle and posteriorly Dehydrothermal crosslinking, using three different treatments: 24, 48 and 72h. The products were characterized by XRD, FTIR, SEM, Archimedes Method, compression tests and TGA-DSC. All the composites manufactured showed a porous structure, revealing values in the range of 84 to 87%.The β-TCP particles were homogeneously distributed and overlapped in the collagen matrix. The crystalline phases of the samples were studied and the presence of β-TCP was identified. Molecular groups were identified as referring to collagen and β-TCP. The observed amide peaks I, II, III, A and B tend to be less pronounced when the crosslinking exposure time increases, while the phosphate groups were observed with clarity. The products exhibited Young's Modulus values ranging from 180 to 200 kPa. These values tend to increase when the exposure time of crosslinking increases. Mass losses were not considered significant for the crosslinked products, varying between 8 and 11%. However it was shown that the Dehydrothermal crosslinking minimizes mass losses when compared to composites without this treatment. It is possible to conclude that a flexible bone graft was successfully developed. For that reason, the collagen / β-TCP composite showed a better handling when compared to calcium phosphates bone grafts. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-04 2018 2018-05-04T00:00:00Z 2021-03-26T01:30:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/39804 TID:202467996 |
url |
http://hdl.handle.net/10362/39804 |
identifier_str_mv |
TID:202467996 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137933824884736 |