Nanotechnology in peripheral nerve repair and reconstruction

Detalhes bibliográficos
Autor(a) principal: Carvalho, C. R.
Data de Publicação: 2019
Outros Autores: Silva-Correia, J., Oliveira, Joaquim M., Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58770
Resumo: The recent progress in biomaterials science and development of tubular conduits (TCs) still fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in particular when disease-related and long-gap defects need to be addressed. Nanotechnology-based therapies that seemed unreachable in the past are now being considered for the repair and reconstruction of PNIs, having the power to deliver bioactive molecules in a controlled manner, to tune cellular behavior, and ultimately guide tissue regeneration in an effective manner. It also offers opportunities in the imaging field, with a degree of precision never achieved before, which is useful for diagnosis, surgery and in the patientâ s follow-up. Nanotechnology approaches applied in PNI regeneration and theranostics, emphasizing the ones that are moving from the lab bench to the clinics, are herein overviewed.
id RCAP_f4737ca616c94cc51effba2c163916a9
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/58770
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Nanotechnology in peripheral nerve repair and reconstructionNanomedicinenanotechnologyPeripheral Nerve RegenerationCarbon nanomaterialsNanoparticlesNanofibersNanoimagingRepairTubular conduitsScience & TechnologyThe recent progress in biomaterials science and development of tubular conduits (TCs) still fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in particular when disease-related and long-gap defects need to be addressed. Nanotechnology-based therapies that seemed unreachable in the past are now being considered for the repair and reconstruction of PNIs, having the power to deliver bioactive molecules in a controlled manner, to tune cellular behavior, and ultimately guide tissue regeneration in an effective manner. It also offers opportunities in the imaging field, with a degree of precision never achieved before, which is useful for diagnosis, surgery and in the patientâ s follow-up. Nanotechnology approaches applied in PNI regeneration and theranostics, emphasizing the ones that are moving from the lab bench to the clinics, are herein overviewed.The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for the financial support provided to Joaquim M. Oliveira (IF/01285/2015) and Joana Silva-Correia (IF/00115/2015) under the program “Investigador FCT”.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoCarvalho, C. R.Silva-Correia, J.Oliveira, Joaquim M.Reis, R. L.2019-012019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58770engCarvalho C. R., Silva-Correia J., Oliveira J. M., Reis R. L. Nanotechnology in Peripheral Nerve Repair and Reconstruction, Advanced Drug Delivery Reviews, doi:10.1016/j.addr.2019.01.006, 20190169-409X1872-829410.1016/j.addr.2019.01.00630639255https://www.sciencedirect.com/science/article/pii/S0169409X19300092info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:37:34Zoai:repositorium.sdum.uminho.pt:1822/58770Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:33:52.906683Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanotechnology in peripheral nerve repair and reconstruction
title Nanotechnology in peripheral nerve repair and reconstruction
spellingShingle Nanotechnology in peripheral nerve repair and reconstruction
Carvalho, C. R.
Nanomedicine
nanotechnology
Peripheral Nerve Regeneration
Carbon nanomaterials
Nanoparticles
Nanofibers
Nanoimaging
Repair
Tubular conduits
Science & Technology
title_short Nanotechnology in peripheral nerve repair and reconstruction
title_full Nanotechnology in peripheral nerve repair and reconstruction
title_fullStr Nanotechnology in peripheral nerve repair and reconstruction
title_full_unstemmed Nanotechnology in peripheral nerve repair and reconstruction
title_sort Nanotechnology in peripheral nerve repair and reconstruction
author Carvalho, C. R.
author_facet Carvalho, C. R.
Silva-Correia, J.
Oliveira, Joaquim M.
Reis, R. L.
author_role author
author2 Silva-Correia, J.
Oliveira, Joaquim M.
Reis, R. L.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Carvalho, C. R.
Silva-Correia, J.
Oliveira, Joaquim M.
Reis, R. L.
dc.subject.por.fl_str_mv Nanomedicine
nanotechnology
Peripheral Nerve Regeneration
Carbon nanomaterials
Nanoparticles
Nanofibers
Nanoimaging
Repair
Tubular conduits
Science & Technology
topic Nanomedicine
nanotechnology
Peripheral Nerve Regeneration
Carbon nanomaterials
Nanoparticles
Nanofibers
Nanoimaging
Repair
Tubular conduits
Science & Technology
description The recent progress in biomaterials science and development of tubular conduits (TCs) still fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in particular when disease-related and long-gap defects need to be addressed. Nanotechnology-based therapies that seemed unreachable in the past are now being considered for the repair and reconstruction of PNIs, having the power to deliver bioactive molecules in a controlled manner, to tune cellular behavior, and ultimately guide tissue regeneration in an effective manner. It also offers opportunities in the imaging field, with a degree of precision never achieved before, which is useful for diagnosis, surgery and in the patientâ s follow-up. Nanotechnology approaches applied in PNI regeneration and theranostics, emphasizing the ones that are moving from the lab bench to the clinics, are herein overviewed.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58770
url http://hdl.handle.net/1822/58770
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carvalho C. R., Silva-Correia J., Oliveira J. M., Reis R. L. Nanotechnology in Peripheral Nerve Repair and Reconstruction, Advanced Drug Delivery Reviews, doi:10.1016/j.addr.2019.01.006, 2019
0169-409X
1872-8294
10.1016/j.addr.2019.01.006
30639255
https://www.sciencedirect.com/science/article/pii/S0169409X19300092
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132858450706432

Registros relacionados