Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/9229 |
Resumo: | Background: Hearing loss is a problem with higher incidence in South Asia, Asia Pacific and sub-Saharan Africa. In these countries there is also associated history of anemia and malaria. Objective: This study aims to identify a putative role of Beta globin mutation - sickle cell trait and HL in São Tomé and Príncipe population. Methods: A retrospective case-control study of a convenience sample was collected during Otolaryngologist Humanitarian Missions in São Tomé and Príncipe. Control group includes individuals with normal hearing in both ears, and the case group has participants presenting bilateral or unilateral HL. It was evaluated the potential risk factors and sickle cell trait with HL, as well self-report of malaria infection, consanguinity, familial history of HL. The HbS gene point mutation (Glu6Val) was determined by PCR-RFLP. Results: Our results showed a statistical significance between HL - oral language and self-report of HL. Taken altogether, our data did not reveal association between sickle cell trait and HL. However, a statistical association between HL and self-report of malaria was found. Conclusion: No association between sickle cell trait and the high prevalence of HL was found. Self-report of Malaria was found as a risk factor for the development of HL in São Tomé and Príncipe population. The multifactorial profile of HL shall not exclude the relevance of other etiologic factors than Malaria to justify the high prevalence of HL in São Tomé and Príncipe and further investigation must be applied. |
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Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and PríncipeOtolaryngologyORLHearing lossSensorineural hearing lossSickle cell traitSickle cell diseaseMalariaHemoglobinopathySao Tome and PrincipeBackground: Hearing loss is a problem with higher incidence in South Asia, Asia Pacific and sub-Saharan Africa. In these countries there is also associated history of anemia and malaria. Objective: This study aims to identify a putative role of Beta globin mutation - sickle cell trait and HL in São Tomé and Príncipe population. Methods: A retrospective case-control study of a convenience sample was collected during Otolaryngologist Humanitarian Missions in São Tomé and Príncipe. Control group includes individuals with normal hearing in both ears, and the case group has participants presenting bilateral or unilateral HL. It was evaluated the potential risk factors and sickle cell trait with HL, as well self-report of malaria infection, consanguinity, familial history of HL. The HbS gene point mutation (Glu6Val) was determined by PCR-RFLP. Results: Our results showed a statistical significance between HL - oral language and self-report of HL. Taken altogether, our data did not reveal association between sickle cell trait and HL. However, a statistical association between HL and self-report of malaria was found. Conclusion: No association between sickle cell trait and the high prevalence of HL was found. Self-report of Malaria was found as a risk factor for the development of HL in São Tomé and Príncipe population. The multifactorial profile of HL shall not exclude the relevance of other etiologic factors than Malaria to justify the high prevalence of HL in São Tomé and Príncipe and further investigation must be applied.OMICS InternationalRCIPLCaroça, CristinaLima, Joao Pereira deCsampelo, PaulaCarolino, ElisabeteCaria, HelenaPaço, JoãoSilva, Susana Nunes2018-12-30T20:05:07Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/9229engCaroça C, Lima JP, Campelo P, Carolino E, Caria H, Paço J, et al. Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe. Otolaryngol (Sunnyvale). 2016;6(6):1000278.10.4172/2161-119X.1000278info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:57:41Zoai:repositorio.ipl.pt:10400.21/9229Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:17:50.786386Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
title |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
spellingShingle |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe Caroça, Cristina Otolaryngology ORL Hearing loss Sensorineural hearing loss Sickle cell trait Sickle cell disease Malaria Hemoglobinopathy Sao Tome and Principe |
title_short |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
title_full |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
title_fullStr |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
title_full_unstemmed |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
title_sort |
Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe |
author |
Caroça, Cristina |
author_facet |
Caroça, Cristina Lima, Joao Pereira de Csampelo, Paula Carolino, Elisabete Caria, Helena Paço, João Silva, Susana Nunes |
author_role |
author |
author2 |
Lima, Joao Pereira de Csampelo, Paula Carolino, Elisabete Caria, Helena Paço, João Silva, Susana Nunes |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Caroça, Cristina Lima, Joao Pereira de Csampelo, Paula Carolino, Elisabete Caria, Helena Paço, João Silva, Susana Nunes |
dc.subject.por.fl_str_mv |
Otolaryngology ORL Hearing loss Sensorineural hearing loss Sickle cell trait Sickle cell disease Malaria Hemoglobinopathy Sao Tome and Principe |
topic |
Otolaryngology ORL Hearing loss Sensorineural hearing loss Sickle cell trait Sickle cell disease Malaria Hemoglobinopathy Sao Tome and Principe |
description |
Background: Hearing loss is a problem with higher incidence in South Asia, Asia Pacific and sub-Saharan Africa. In these countries there is also associated history of anemia and malaria. Objective: This study aims to identify a putative role of Beta globin mutation - sickle cell trait and HL in São Tomé and Príncipe population. Methods: A retrospective case-control study of a convenience sample was collected during Otolaryngologist Humanitarian Missions in São Tomé and Príncipe. Control group includes individuals with normal hearing in both ears, and the case group has participants presenting bilateral or unilateral HL. It was evaluated the potential risk factors and sickle cell trait with HL, as well self-report of malaria infection, consanguinity, familial history of HL. The HbS gene point mutation (Glu6Val) was determined by PCR-RFLP. Results: Our results showed a statistical significance between HL - oral language and self-report of HL. Taken altogether, our data did not reveal association between sickle cell trait and HL. However, a statistical association between HL and self-report of malaria was found. Conclusion: No association between sickle cell trait and the high prevalence of HL was found. Self-report of Malaria was found as a risk factor for the development of HL in São Tomé and Príncipe population. The multifactorial profile of HL shall not exclude the relevance of other etiologic factors than Malaria to justify the high prevalence of HL in São Tomé and Príncipe and further investigation must be applied. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z 2018-12-30T20:05:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/9229 |
url |
http://hdl.handle.net/10400.21/9229 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Caroça C, Lima JP, Campelo P, Carolino E, Caria H, Paço J, et al. Sickle cell trait, malaria and sensorineural hearing loss: a case-control study from São Tomé and Príncipe. Otolaryngol (Sunnyvale). 2016;6(6):1000278. 10.4172/2161-119X.1000278 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
OMICS International |
publisher.none.fl_str_mv |
OMICS International |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133441863712768 |