Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future?
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.24915/aup.33.3.36 |
Resumo: | In the PSA era, the incidence of localized prostate cancer has been increasing. This reality requires new therapeutic strategies, in order to give an answer to patients, in whom active surveillance may be indicate but desire more interventionist strategy with minimal side effects and without compromising cancer control. In these cases, focal therapies that include irreversible electroporation may be effective alternative strategies. The irreversible electroporation is an emergent approach on focal treatment of localized PCa. The nonthermal mechanism that preserves the tissue architecture without damaging tissue structures, such as vessels and nerves within the target region, is the main advantage comparatively to other techniques used in focal treatment. The number of clinical studies is reduced and the results still immature. |
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Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future?Terapêuticas focais no tratamento do carcinoma da próstata localizado: o papel da eletroporação irreversível – presente ou futuro?Prostate cancerFocal therapyFocal treatmentElectroporationCarcinoma da próstataTerapêutica focalTratamento focalEletroporaçãoIn the PSA era, the incidence of localized prostate cancer has been increasing. This reality requires new therapeutic strategies, in order to give an answer to patients, in whom active surveillance may be indicate but desire more interventionist strategy with minimal side effects and without compromising cancer control. In these cases, focal therapies that include irreversible electroporation may be effective alternative strategies. The irreversible electroporation is an emergent approach on focal treatment of localized PCa. The nonthermal mechanism that preserves the tissue architecture without damaging tissue structures, such as vessels and nerves within the target region, is the main advantage comparatively to other techniques used in focal treatment. The number of clinical studies is reduced and the results still immature.Na era do PSA, a incidência do carcinoma da próstata localizado tem vindo a aumentar. Esta realidade exige novas estratégias terapêuticas, a fim de poder dar uma resposta aos pacientes, os quais, embora esteja indicada a vigilância ativa, desejam uma estratégia mais interventiva com poucos efeitos adversos e sem compromisso do controlo da doença. Nestes casos, as terapêuticas focais, que incluem a eletroporação irreversível, podem ser uma estratégia alternativa efetiva. A eletroporação irreversível constitui uma abordagem emergente no tratamento do carcinoma da próstata localizado. O mecanismo de lesão celular não-térmico que preserva a arquitetura tecidular sem lesão de estruturas, tais como vasos e nervos dentro da região alvo, constitui a principal vantagem comparativamente com as outras técnicas utilizadas no tratamento focal. O número de estudos clínicos é reduzido e os resultados ainda são imaturos.Associação Portuguesa de Urologia2017-04-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.24915/aup.33.3.36oai:oai.actaurologicaportuguesa.com:article/36Acta Urológica Portuguesa; Vol. 33 No. 3 (2016): Setembro-Dezembro; 104-108Acta Urológica Portuguesa; v. 33 n. 3 (2016): Setembro-Dezembro; 104-1082387-04192341-4022reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://www.actaurologicaportuguesa.com/index.php/aup/article/view/36https://doi.org/10.24915/aup.33.3.36http://www.actaurologicaportuguesa.com/index.php/aup/article/view/36/6Conceição Fernandes, PedroPereira, Bruno Jorgeinfo:eu-repo/semantics/openAccess2022-09-21T09:04:45Zoai:oai.actaurologicaportuguesa.com:article/36Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:52.617903Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? Terapêuticas focais no tratamento do carcinoma da próstata localizado: o papel da eletroporação irreversível – presente ou futuro? |
title |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? |
spellingShingle |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? Conceição Fernandes, Pedro Prostate cancer Focal therapy Focal treatment Electroporation Carcinoma da próstata Terapêutica focal Tratamento focal Eletroporação |
title_short |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? |
title_full |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? |
title_fullStr |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? |
title_full_unstemmed |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? |
title_sort |
Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future? |
author |
Conceição Fernandes, Pedro |
author_facet |
Conceição Fernandes, Pedro Pereira, Bruno Jorge |
author_role |
author |
author2 |
Pereira, Bruno Jorge |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Conceição Fernandes, Pedro Pereira, Bruno Jorge |
dc.subject.por.fl_str_mv |
Prostate cancer Focal therapy Focal treatment Electroporation Carcinoma da próstata Terapêutica focal Tratamento focal Eletroporação |
topic |
Prostate cancer Focal therapy Focal treatment Electroporation Carcinoma da próstata Terapêutica focal Tratamento focal Eletroporação |
description |
In the PSA era, the incidence of localized prostate cancer has been increasing. This reality requires new therapeutic strategies, in order to give an answer to patients, in whom active surveillance may be indicate but desire more interventionist strategy with minimal side effects and without compromising cancer control. In these cases, focal therapies that include irreversible electroporation may be effective alternative strategies. The irreversible electroporation is an emergent approach on focal treatment of localized PCa. The nonthermal mechanism that preserves the tissue architecture without damaging tissue structures, such as vessels and nerves within the target region, is the main advantage comparatively to other techniques used in focal treatment. The number of clinical studies is reduced and the results still immature. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.24915/aup.33.3.36 oai:oai.actaurologicaportuguesa.com:article/36 |
url |
https://doi.org/10.24915/aup.33.3.36 |
identifier_str_mv |
oai:oai.actaurologicaportuguesa.com:article/36 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.actaurologicaportuguesa.com/index.php/aup/article/view/36 https://doi.org/10.24915/aup.33.3.36 http://www.actaurologicaportuguesa.com/index.php/aup/article/view/36/6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Associação Portuguesa de Urologia |
publisher.none.fl_str_mv |
Associação Portuguesa de Urologia |
dc.source.none.fl_str_mv |
Acta Urológica Portuguesa; Vol. 33 No. 3 (2016): Setembro-Dezembro; 104-108 Acta Urológica Portuguesa; v. 33 n. 3 (2016): Setembro-Dezembro; 104-108 2387-0419 2341-4022 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130427649163264 |