The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Fernandes, Adriana
Data de Publicação: 2023
Outros Autores: David, Cláudio, Pinto, Fausto J., Costa, João, Ferreira, Joaquim J, Caldeira, Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/57526
Resumo: © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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spelling The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysisHypertensionPlaceboRenal denervationRenal sympathetic denervationSham© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Renal denervation (RDN) has emerged in recent years as a possible treatment for hypertension. The first sham-controlled trial showed a small magnitude and non-significant in the blood pressure (BP) lowering effect, also due to a substantial decrease of BP in sham arm. Considering this, we aimed to quantify the magnitude of BP decrease within the sham arm of Randomized Controlled Trials (RCT) with RDN in patients with hypertension. Methods: Electronic databases were searched since inception until January 2022 for randomized sham-controlled trials which assessed the efficacy in lowering BP of the sham intervention for catheter-based RDN in adult patients with hypertension. The outcomes were change in ambulatory/office systolic and diastolic BP. Results: A total of 9 RCT were included in the analysis enrolling a total of 674 patients. Sham intervention showed a decrease in all evaluated outcomes. Office systolic BP had a reduction of -5.52 mmHg [95%CI -7.91, -3.13] and office diastolic BP of -2.13 mmHg [95%CI -3.08, -1.17]. Sham procedure for RDN also showed a reduction of -3.41 mmHg [95%CI -5.08, -1.75] in ambulatory systolic BP and - 2.44 mmHg [95%CI -3.31, -1.57] in ambulatory diastolic BP. Conclusion: Despite recent data indicating that RDN might be an effective treatment for patients with resistant hypertension when compared to a sham intervention, our results indicate that the sham intervention for RDN also has a significant effect on lowering Office and Ambulatory (24-h) Blood Pressure in adult patients with hypertension. This highlights that BP itself might be sensitive to placebo-like effect and also brings further difficulties in establishing the BP lowering efficacy of invasive interventions due to the magnitude of the sham effect.This work was supported by national funds, Fundação para a Ciência e a Tecnologia, reference number UIDB/00306/2020.Springer NatureRepositório da Universidade de LisboaFernandes, AdrianaDavid, CláudioPinto, Fausto J.Costa, JoãoFerreira, Joaquim JCaldeira, Daniel2023-05-23T11:14:52Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57526engBMC Cardiovasc Disord. 2023 May 12;23(1):24910.1186/s12872-023-03269-w1471-2261info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:54Zoai:repositorio.ul.pt:10451/57526Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:56.964034Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
title The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
spellingShingle The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
Fernandes, Adriana
Hypertension
Placebo
Renal denervation
Renal sympathetic denervation
Sham
title_short The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
title_full The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
title_fullStr The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
title_full_unstemmed The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
title_sort The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis
author Fernandes, Adriana
author_facet Fernandes, Adriana
David, Cláudio
Pinto, Fausto J.
Costa, João
Ferreira, Joaquim J
Caldeira, Daniel
author_role author
author2 David, Cláudio
Pinto, Fausto J.
Costa, João
Ferreira, Joaquim J
Caldeira, Daniel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fernandes, Adriana
David, Cláudio
Pinto, Fausto J.
Costa, João
Ferreira, Joaquim J
Caldeira, Daniel
dc.subject.por.fl_str_mv Hypertension
Placebo
Renal denervation
Renal sympathetic denervation
Sham
topic Hypertension
Placebo
Renal denervation
Renal sympathetic denervation
Sham
description © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-23T11:14:52Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57526
url http://hdl.handle.net/10451/57526
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Cardiovasc Disord. 2023 May 12;23(1):249
10.1186/s12872-023-03269-w
1471-2261
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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