Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

Detalhes bibliográficos
Autor(a) principal: Melo, Bernardete F.
Data de Publicação: 2021
Outros Autores: Prieto-Lloret, Jesus, Cabral, Marlene D., Martins, Fatima O., Martins, Inês B., Sacramento, Joana F., Ruivo, Pedro, Carvalho, Tânia, Conde, Silvia V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46958
Resumo: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulation and the mechanisms promoting the dysfunction, using pulmonary artery (PA) and aorta. A high-fat (HF, 3 weeks 60% lipid-rich diet) and a high-fat/high-sucrose (HFHSu, combined 60% lipid-rich diet and 35% sucrose during 25 weeks) groups were used as prediabetes and T2D rat models. We found that T2D progression differently affects endothelial function and vascular contractility in the aorta and PA, with the contractile machinery being altered in the PA and aorta in prediabetes and T2D animals; and endothelial function being affected in both models in the aorta but only affected in the PA of T2D animals, meaning that PA is more resistant than aorta to endothelial dysfunction. Additionally, PA and systemic endothelial dysfunction in diabetic rats were associated with alterations in the nitrergic system and inflammatory pathways. PA dysfunction in T2D involves endothelial wall mineralization. The understanding of the mechanisms behind PA dysfunction in T2D can lead to significant advances in both preventative and therapeutic treatments of pulmonary disease-associated diabetes.B.F.M. is supported by PhD Grant from Portuguese Foundation for Science and Technology Reference PD/BD/128336/2017. FOM and JFS are supported by Portuguese Foundation for Science and Technology contracts CEECIND/04266/2017 and CEECIND/02428/2018.Springer NatureRepositório da Universidade de LisboaMelo, Bernardete F.Prieto-Lloret, JesusCabral, Marlene D.Martins, Fatima O.Martins, Inês B.Sacramento, Joana F.Ruivo, PedroCarvalho, TâniaConde, Silvia V.2021-03-22T13:51:08Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46958engSci Rep 11, 6052 (2021)10.1038/s41598-021-85606-72045-2322info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:33Zoai:repositorio.ul.pt:10451/46958Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:04.269625Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
spellingShingle Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
Melo, Bernardete F.
title_short Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_full Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_fullStr Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_full_unstemmed Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_sort Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
author Melo, Bernardete F.
author_facet Melo, Bernardete F.
Prieto-Lloret, Jesus
Cabral, Marlene D.
Martins, Fatima O.
Martins, Inês B.
Sacramento, Joana F.
Ruivo, Pedro
Carvalho, Tânia
Conde, Silvia V.
author_role author
author2 Prieto-Lloret, Jesus
Cabral, Marlene D.
Martins, Fatima O.
Martins, Inês B.
Sacramento, Joana F.
Ruivo, Pedro
Carvalho, Tânia
Conde, Silvia V.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Melo, Bernardete F.
Prieto-Lloret, Jesus
Cabral, Marlene D.
Martins, Fatima O.
Martins, Inês B.
Sacramento, Joana F.
Ruivo, Pedro
Carvalho, Tânia
Conde, Silvia V.
description © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-22T13:51:08Z
2021
2021-01-01T00:00:00Z
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Sci Rep 11, 6052 (2021)
10.1038/s41598-021-85606-7
2045-2322
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publisher.none.fl_str_mv Springer Nature
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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