Emerging human pathogens from the Shewanella genus: understanding the molecular mechanism behind ferric iron-siderophore reduction

• Autor(a) principal: Trindade, Inês de Brito
• Data de Publicação: 2016
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/69936
• topic: Electrochemistry; Iron uptake; Nuclear Magnetic Ressonance; Shewanella; Biochemistry

"Shewanella are Gram-negative rod-shaped bacteria that colonize diverse environments. Nevertheless, over the past years, reports have increasingly identified particular Shewanella spp. as opportunistic human pathogens. Reaching up to almost 300 cases of accounted infections, higher frequency was found in warm climates and usually includes the exposure to sea water. To date there is virtually no research on Shewanella’s pathogenicity, however iron acquisition during infection of a host plays an important role and it is a challenge that every pathogen encounters. Siderophore-mediated iron acquisition provides pathogens with the ability of circumventing the host’s immune defense and for this reason the siderophore pathway has been extensively explored. One of the least explored processes is siderophore recycling, the reduction of the ferric siderophores mediated by siderophore-interacting proteins. These fall into two subfamilies, the SIP flavoproteins and the FSR proteins containing an iron-sulfur cluster.(...)"