Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

Detalhes bibliográficos
Autor(a) principal: Wircer, Einav
Data de Publicação: 2017
Outros Autores: Blechman, Janna, Borodovsky, Nataliya, Tsoory, Michael, Nunes, Ana Rita, Oliveira, Rui F, Levkowitz, Gil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/742
Resumo: No supplementary materials.
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spelling Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behaviorautismdevelopmental biologyhypothalamusneurodevelopment disordersneuropeptidesneuroscienceoxytocinsocial behaviorstem cellszebrafishNo supplementary materials.Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene otpa but not otpb affect both stress response and social preference. These behavioral phenotypes were associated with developmental alterations in oxytocinergic (OXT) neurons. Thus, otpa and otpb differentially regulate neuropeptide switching in a newly identified subset of OXT neurons that co-express the corticotropin-releasing hormone (CRH). Single-cell analysis revealed that these neurons project mostly to the hindbrain and spinal cord. Ablation of this neuronal subset specifically reduced adult social preference without affecting stress behavior, thereby uncoupling the contribution of a specific OXT cluster to social behavior from the general otpa(-/-) deficits. Our findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete OXT circuit whose disrupted development affects social behavior.Israel Science Foundation grants: (1511/16, 957/12, 2137/16).eLife Sciences PublicationsARCAWircer, EinavBlechman, JannaBorodovsky, NataliyaTsoory, MichaelNunes, Ana RitaOliveira, Rui FLevkowitz, Gil2017-04-03T14:52:19Z2017-01-172017-01-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/742engeLife 2017;6:e2217010.7554/eLife.22170info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:08Zoai:arca.igc.gulbenkian.pt:10400.7/742Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:58.214094Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
title Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
spellingShingle Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
Wircer, Einav
autism
developmental biology
hypothalamus
neurodevelopment disorders
neuropeptides
neuroscience
oxytocin
social behavior
stem cells
zebrafish
title_short Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
title_full Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
title_fullStr Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
title_full_unstemmed Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
title_sort Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
author Wircer, Einav
author_facet Wircer, Einav
Blechman, Janna
Borodovsky, Nataliya
Tsoory, Michael
Nunes, Ana Rita
Oliveira, Rui F
Levkowitz, Gil
author_role author
author2 Blechman, Janna
Borodovsky, Nataliya
Tsoory, Michael
Nunes, Ana Rita
Oliveira, Rui F
Levkowitz, Gil
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Wircer, Einav
Blechman, Janna
Borodovsky, Nataliya
Tsoory, Michael
Nunes, Ana Rita
Oliveira, Rui F
Levkowitz, Gil
dc.subject.por.fl_str_mv autism
developmental biology
hypothalamus
neurodevelopment disorders
neuropeptides
neuroscience
oxytocin
social behavior
stem cells
zebrafish
topic autism
developmental biology
hypothalamus
neurodevelopment disorders
neuropeptides
neuroscience
oxytocin
social behavior
stem cells
zebrafish
description No supplementary materials.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-03T14:52:19Z
2017-01-17
2017-01-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/742
url http://hdl.handle.net/10400.7/742
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv eLife 2017;6:e22170
10.7554/eLife.22170
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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