Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores

Detalhes bibliográficos
Autor(a) principal: Amaral, A J
Data de Publicação: 2020
Outros Autores: Pavao, Ana L., Gama, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24098
Resumo: Research Areas: Agriculture ; Veterinary Sciences ; Zoology
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spelling Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the AzoresFunctional genomicsGWASInbreedingLocal breedsROHSingle nucleotide polymorphisms (SNPs)Research Areas: Agriculture ; Veterinary Sciences ; ZoologyRamo Grande is a local cattle breed raised in the archipelago of Azores, with a small and dispersed census, where inbreeding control is of utmost importance. A single nucleotide polymorphism (SNP) Beadchip array was used to assess inbreeding, by analysis of genomic regions harboring contiguous homozygous genotypes named runs of homozygosity (ROH), and to estimate past e ective population size by analysis of linkage disequilibrium (LD). Genetic markers associated with production traits were also investigated, exploiting the unique genetic and adaptation features of this breed. A total of 639 ROH with length >4 Mb were identified, with mean length of 14.96 Mb. The mean genomic inbreeding was 0.09, and long segments of ROH were common, indicating recent inbred matings. The LD pattern indicates a large e ective population size, suggesting the inflow of exotic germplasm in the past. The genome-wide association study identified novel markers significantly a ecting longevity, age at first calving and direct genetic e ects on calf weight. These results provide the first evidence of the association of longevity with genes related with DNA recognition and repair, and the association of age at first calving with aquaporin proteins, which are known to have a crucial role in reproduction.MDPIRepositório da Universidade de LisboaAmaral, A JPavao, Ana L.Gama, Luis2022-04-18T14:28:44Z2020-06-242020-06-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24098engAmaral AJ, Pavao AL, Gama LT. 2020. Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores. Animal, 10(6):1089. Doi 10.3390/ani100610892076-261510.3390/ani10061089info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:44Zoai:www.repository.utl.pt:10400.5/24098Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:13.208050Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
title Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
spellingShingle Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
Amaral, A J
Functional genomics
GWAS
Inbreeding
Local breeds
ROH
Single nucleotide polymorphisms (SNPs)
title_short Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
title_full Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
title_fullStr Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
title_full_unstemmed Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
title_sort Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores
author Amaral, A J
author_facet Amaral, A J
Pavao, Ana L.
Gama, Luis
author_role author
author2 Pavao, Ana L.
Gama, Luis
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Amaral, A J
Pavao, Ana L.
Gama, Luis
dc.subject.por.fl_str_mv Functional genomics
GWAS
Inbreeding
Local breeds
ROH
Single nucleotide polymorphisms (SNPs)
topic Functional genomics
GWAS
Inbreeding
Local breeds
ROH
Single nucleotide polymorphisms (SNPs)
description Research Areas: Agriculture ; Veterinary Sciences ; Zoology
publishDate 2020
dc.date.none.fl_str_mv 2020-06-24
2020-06-24T00:00:00Z
2022-04-18T14:28:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24098
url http://hdl.handle.net/10400.5/24098
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amaral AJ, Pavao AL, Gama LT. 2020. Genomic tools for the conservation and genetic improvement of a highly fragmented breed : the ramo grande cattle from the Azores. Animal, 10(6):1089. Doi 10.3390/ani10061089
2076-2615
10.3390/ani10061089
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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