Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis

Detalhes bibliográficos
Autor(a) principal: Moura, Luis M.
Data de Publicação: 2012
Outros Autores: Faria, Susana, Brito, Miguel, Pinto, Fausto J., Kristensen, Steen D., Barros, Isabel M., Rajamannan, Nalini, Gonçalves, Francisco Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/35324
Resumo: AJCD Copyright © 2012
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spelling Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosisCalcific aortic stenosisPolymorphismParaoxonaseAtherosclerosisGeneticsAssociationAJCD Copyright © 2012Introduction and Objectives: Paraoxonases may exert anti-atherogenic action by reducing lipid peroxidation. Previous studies examined associations between polymorphisms in the paraoxonase 1 (PON1) gene and development of coronary artery disease (CAD), with inconsistent results. Given the similarities in clinical and pathophysiological risk factors of CAD and calcific aortic valve stenosis (CAVS), we postulated a link between PON1 alleles and CAVS progression. Methods: We investigated the association between PON1 55 and 192 single nucleotide polymorphisms (SNPs), their enzyme activity, and CAVS progression assessed by aortic valve area and transvalvular peak velocity in 67 consecutive patients with moderate CAVS and 251 healthy controls. Results: PON1 paraoxonase activity was higher in CAVS patients (P<0.001). The PON1 genotype Q192R SNP (P=0.03) and variant allele (R192) (P=0.01) frequencies differed between CAVS patients and controls. Significant association existed between PON1 enzyme activity, phenotypic effects of PON1 192 genotype polymorphisms, and CAVS progression, but not between PON1 55 and high-density lipoprotein (P=0.44) or low-density lipoprotein cholesterol (P=0.12), between 192 genotype and high -density lipoprotein (P=0.24) or low-density lipoprotein cholesterol (P=0.52). Conclusion: The PON1 genotype Q192R SNP has an important effect on CAVS disease progression. This study helps outline a genotype-phenotype relationship for PON1 in this unique population.e-Century PublishingRepositório da Universidade de LisboaMoura, Luis M.Faria, SusanaBrito, MiguelPinto, Fausto J.Kristensen, Steen D.Barros, Isabel M.Rajamannan, NaliniGonçalves, Francisco Rocha2018-11-14T12:14:47Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/35324engAm J Cardiovasc Dis. 2012; 2(2): 123–1322160-200Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:31:12Zoai:repositorio.ul.pt:10451/35324Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:49:48.237622Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
title Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
spellingShingle Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
Moura, Luis M.
Calcific aortic stenosis
Polymorphism
Paraoxonase
Atherosclerosis
Genetics
Association
title_short Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
title_full Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
title_fullStr Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
title_full_unstemmed Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
title_sort Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis
author Moura, Luis M.
author_facet Moura, Luis M.
Faria, Susana
Brito, Miguel
Pinto, Fausto J.
Kristensen, Steen D.
Barros, Isabel M.
Rajamannan, Nalini
Gonçalves, Francisco Rocha
author_role author
author2 Faria, Susana
Brito, Miguel
Pinto, Fausto J.
Kristensen, Steen D.
Barros, Isabel M.
Rajamannan, Nalini
Gonçalves, Francisco Rocha
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Moura, Luis M.
Faria, Susana
Brito, Miguel
Pinto, Fausto J.
Kristensen, Steen D.
Barros, Isabel M.
Rajamannan, Nalini
Gonçalves, Francisco Rocha
dc.subject.por.fl_str_mv Calcific aortic stenosis
Polymorphism
Paraoxonase
Atherosclerosis
Genetics
Association
topic Calcific aortic stenosis
Polymorphism
Paraoxonase
Atherosclerosis
Genetics
Association
description AJCD Copyright © 2012
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2018-11-14T12:14:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/35324
url http://hdl.handle.net/10451/35324
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Am J Cardiovasc Dis. 2012; 2(2): 123–132
2160-200X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv e-Century Publishing
publisher.none.fl_str_mv e-Century Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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