Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/154861 |
Resumo: | Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent. |
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Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer TherapyPaclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent.Hindawi20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/154861eng1942-090010.1155/2021/3687700Sharifi-Rad, JQuispe, CPatra, JKSingh, YDPanda, MKDas, GAdetunji, COMichael, OSSytar, OPolito, LŽivkovic, JMartins, NKlimek-Szczykutowicz, MEkiert, HChoudhary, MIAyatollahi, SATynybekov, BKobarfard, FMuntean, ACGrozea, IDastan, SDButnariu, MSzopa, ACalina, Dinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:24:22Zoai:repositorio-aberto.up.pt:10216/154861Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:22:51.983350Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
title |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
spellingShingle |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy Sharifi-Rad, J |
title_short |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
title_full |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
title_fullStr |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
title_full_unstemmed |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
title_sort |
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy |
author |
Sharifi-Rad, J |
author_facet |
Sharifi-Rad, J Quispe, C Patra, JK Singh, YD Panda, MK Das, G Adetunji, CO Michael, OS Sytar, O Polito, L Živkovic, J Martins, N Klimek-Szczykutowicz, M Ekiert, H Choudhary, MI Ayatollahi, SA Tynybekov, B Kobarfard, F Muntean, AC Grozea, I Dastan, SD Butnariu, M Szopa, A Calina, D |
author_role |
author |
author2 |
Quispe, C Patra, JK Singh, YD Panda, MK Das, G Adetunji, CO Michael, OS Sytar, O Polito, L Živkovic, J Martins, N Klimek-Szczykutowicz, M Ekiert, H Choudhary, MI Ayatollahi, SA Tynybekov, B Kobarfard, F Muntean, AC Grozea, I Dastan, SD Butnariu, M Szopa, A Calina, D |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sharifi-Rad, J Quispe, C Patra, JK Singh, YD Panda, MK Das, G Adetunji, CO Michael, OS Sytar, O Polito, L Živkovic, J Martins, N Klimek-Szczykutowicz, M Ekiert, H Choudhary, MI Ayatollahi, SA Tynybekov, B Kobarfard, F Muntean, AC Grozea, I Dastan, SD Butnariu, M Szopa, A Calina, D |
description |
Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/154861 |
url |
https://hdl.handle.net/10216/154861 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1942-0900 10.1155/2021/3687700 |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi |
publisher.none.fl_str_mv |
Hindawi |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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