Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy

Detalhes bibliográficos
Autor(a) principal: Sharifi-Rad, J
Data de Publicação: 2021
Outros Autores: Quispe, C, Patra, JK, Singh, YD, Panda, MK, Das, G, Adetunji, CO, Michael, OS, Sytar, O, Polito, L, Živkovic, J, Martins, N, Klimek-Szczykutowicz, M, Ekiert, H, Choudhary, MI, Ayatollahi, SA, Tynybekov, B, Kobarfard, F, Muntean, AC, Grozea, I, Dastan, SD, Butnariu, M, Szopa, A, Calina, D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/154861
Resumo: Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent.
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spelling Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer TherapyPaclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent.Hindawi20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/154861eng1942-090010.1155/2021/3687700Sharifi-Rad, JQuispe, CPatra, JKSingh, YDPanda, MKDas, GAdetunji, COMichael, OSSytar, OPolito, LŽivkovic, JMartins, NKlimek-Szczykutowicz, MEkiert, HChoudhary, MIAyatollahi, SATynybekov, BKobarfard, FMuntean, ACGrozea, IDastan, SDButnariu, MSzopa, ACalina, Dinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:24:22Zoai:repositorio-aberto.up.pt:10216/154861Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:22:51.983350Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
title Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
spellingShingle Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
Sharifi-Rad, J
title_short Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
title_full Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
title_fullStr Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
title_full_unstemmed Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
title_sort Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
author Sharifi-Rad, J
author_facet Sharifi-Rad, J
Quispe, C
Patra, JK
Singh, YD
Panda, MK
Das, G
Adetunji, CO
Michael, OS
Sytar, O
Polito, L
Živkovic, J
Martins, N
Klimek-Szczykutowicz, M
Ekiert, H
Choudhary, MI
Ayatollahi, SA
Tynybekov, B
Kobarfard, F
Muntean, AC
Grozea, I
Dastan, SD
Butnariu, M
Szopa, A
Calina, D
author_role author
author2 Quispe, C
Patra, JK
Singh, YD
Panda, MK
Das, G
Adetunji, CO
Michael, OS
Sytar, O
Polito, L
Živkovic, J
Martins, N
Klimek-Szczykutowicz, M
Ekiert, H
Choudhary, MI
Ayatollahi, SA
Tynybekov, B
Kobarfard, F
Muntean, AC
Grozea, I
Dastan, SD
Butnariu, M
Szopa, A
Calina, D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sharifi-Rad, J
Quispe, C
Patra, JK
Singh, YD
Panda, MK
Das, G
Adetunji, CO
Michael, OS
Sytar, O
Polito, L
Živkovic, J
Martins, N
Klimek-Szczykutowicz, M
Ekiert, H
Choudhary, MI
Ayatollahi, SA
Tynybekov, B
Kobarfard, F
Muntean, AC
Grozea, I
Dastan, SD
Butnariu, M
Szopa, A
Calina, D
description Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/154861
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10.1155/2021/3687700
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dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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