Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/36502 |
Resumo: | In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance. |
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Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performanceMulti-material structuresNiTi-basedTi6Al4V-basedIn vitroBio-tribological experimentsIn this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance.Elsevier2023-03-08T14:49:20Z2022-07-01T00:00:00Z2022-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/36502eng1751-616110.1016/j.jmbbm.2022.105246Costa, M. M.Lima, R.Alves, N.Silva, N. A.Gasik, M.Silva, F. S.Bartolomeu, F.Miranda, Georginainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:09:49Zoai:ria.ua.pt:10773/36502Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:05.047149Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
title |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
spellingShingle |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance Costa, M. M. Multi-material structures NiTi-based Ti6Al4V-based In vitro Bio-tribological experiments |
title_short |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
title_full |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
title_fullStr |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
title_full_unstemmed |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
title_sort |
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance |
author |
Costa, M. M. |
author_facet |
Costa, M. M. Lima, R. Alves, N. Silva, N. A. Gasik, M. Silva, F. S. Bartolomeu, F. Miranda, Georgina |
author_role |
author |
author2 |
Lima, R. Alves, N. Silva, N. A. Gasik, M. Silva, F. S. Bartolomeu, F. Miranda, Georgina |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, M. M. Lima, R. Alves, N. Silva, N. A. Gasik, M. Silva, F. S. Bartolomeu, F. Miranda, Georgina |
dc.subject.por.fl_str_mv |
Multi-material structures NiTi-based Ti6Al4V-based In vitro Bio-tribological experiments |
topic |
Multi-material structures NiTi-based Ti6Al4V-based In vitro Bio-tribological experiments |
description |
In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-01T00:00:00Z 2022-07 2023-03-08T14:49:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/36502 |
url |
http://hdl.handle.net/10773/36502 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1751-6161 10.1016/j.jmbbm.2022.105246 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137726466883584 |