The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/783 |
Resumo: | The deposited article version is a "Pre-print version" provided by Biorxiv posted online on April 18, 2017 - 12:26, and it contains attached the supplementary materials within the pdf. |
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The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection.population geneticsgenetic structureadmixtureZoroastrianismrecent isolationIranIndiaParsisThe deposited article version is a "Pre-print version" provided by Biorxiv posted online on April 18, 2017 - 12:26, and it contains attached the supplementary materials within the pdf.Zoroastrianism is one of the oldest extant religions in the world, originating in Persia (present-day Iran) during the second millennium BCE. Historical records indicate that migrants from Persia brought Zoroastrianism to India, but there is debate over the timing of these migrations. Here we present genome-wide autosomal, Y chromosome, and mitochondrial DNA data from Iranian and Indian Zoroastrians and neighboring modern-day Indian and Iranian populations and conduct a comprehensive genome-wide genetic analysis in these groups. Using powerful haplotype-based techniques, we find that Zoroastrians in Iran and India have increased genetic homogeneity relative to other sampled groups in their respective countries, consistent with their current practices of endogamy. Despite this, we infer that Indian Zoroastrians (Parsis) intermixed with local groups sometime after their arrival in India, dating this mixture to 690–1390 CE and providing strong evidence that Iranian Zoroastrian ancestry was maintained primarily through the male line. By making use of the rich information in DNA from ancient human remains, we also highlight admixture in the ancestors of Iranian Zoroastrians dated to 570 BCE–746 CE, older than admixture seen in any other sampled Iranian group, consistent with a long-standing isolation of Zoroastrians from outside groups. Finally, we report results, and challenges, from a genome-wide scan to identify genomic regions showing signatures of positive selection in present-day Zoroastrians that might correlate to the prevalence of particular diseases among these communities.BBSRC grant: (BB/L009382/1); Wellcome Trust and the Royal Society Sir Henry Dale Fellowship: (098386/Z/12/Z); National Institute for Health Research University College London Hospitals Biomedical Research Centre; Wellcome Trust Senior Investigator Award grant: (100719/Z/12/Z); EPSRC grant: (EP/F500351/1).ElsevierARCALopez, SaioaThomas, Mark Gvan Dorp, LucyAnsari-Pour, NaserStewart, SarahJones, Abigail LJelinek, ErikChikhi, LounesParfitt, TudorBradman, NeilWeale, Michael EHellenthal, Garrett2017-09-04T14:34:43Z2017-082017-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/783engSaioa López, Mark G. Thomas, Lucy van Dorp, Naser Ansari-Pour, Sarah Stewart, Abigail L. Jones, Erik Jelinek, Lounès Chikhi, Tudor Parfitt, Neil Bradman, Michael E. Weale, Garrett Hellenthal, The Genetic Legacy of Zoroastrianism in Iran and India: Insights into Population Structure, Gene Flow, and Selection, The American Journal of Human Genetics, Available online 24 August 2017, ISSN 0002-9297, https://doi.org/10.1016/j.ajhg.2017.07.013. (http://www.sciencedirect.com/science/article/pii/S0002929717302914)10.1101/128272info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:11Zoai:arca.igc.gulbenkian.pt:10400.7/783Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:00.595171Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| title |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| spellingShingle |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. Lopez, Saioa population genetics genetic structure admixture Zoroastrianism recent isolation Iran India Parsis |
| title_short |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| title_full |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| title_fullStr |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| title_full_unstemmed |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| title_sort |
The genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection. |
| author |
Lopez, Saioa |
| author_facet |
Lopez, Saioa Thomas, Mark G van Dorp, Lucy Ansari-Pour, Naser Stewart, Sarah Jones, Abigail L Jelinek, Erik Chikhi, Lounes Parfitt, Tudor Bradman, Neil Weale, Michael E Hellenthal, Garrett |
| author_role |
author |
| author2 |
Thomas, Mark G van Dorp, Lucy Ansari-Pour, Naser Stewart, Sarah Jones, Abigail L Jelinek, Erik Chikhi, Lounes Parfitt, Tudor Bradman, Neil Weale, Michael E Hellenthal, Garrett |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Lopez, Saioa Thomas, Mark G van Dorp, Lucy Ansari-Pour, Naser Stewart, Sarah Jones, Abigail L Jelinek, Erik Chikhi, Lounes Parfitt, Tudor Bradman, Neil Weale, Michael E Hellenthal, Garrett |
| dc.subject.por.fl_str_mv |
population genetics genetic structure admixture Zoroastrianism recent isolation Iran India Parsis |
| topic |
population genetics genetic structure admixture Zoroastrianism recent isolation Iran India Parsis |
| description |
The deposited article version is a "Pre-print version" provided by Biorxiv posted online on April 18, 2017 - 12:26, and it contains attached the supplementary materials within the pdf. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-09-04T14:34:43Z 2017-08 2017-08-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/783 |
| url |
http://hdl.handle.net/10400.7/783 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Saioa López, Mark G. Thomas, Lucy van Dorp, Naser Ansari-Pour, Sarah Stewart, Abigail L. Jones, Erik Jelinek, Lounès Chikhi, Tudor Parfitt, Neil Bradman, Michael E. Weale, Garrett Hellenthal, The Genetic Legacy of Zoroastrianism in Iran and India: Insights into Population Structure, Gene Flow, and Selection, The American Journal of Human Genetics, Available online 24 August 2017, ISSN 0002-9297, https://doi.org/10.1016/j.ajhg.2017.07.013. (http://www.sciencedirect.com/science/article/pii/S0002929717302914) 10.1101/128272 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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