Potential therapeutic applications of biosurfactants

Detalhes bibliográficos
Autor(a) principal: Gudiña, Eduardo J.
Data de Publicação: 2013
Outros Autores: Rangarajan, Vivek, Ramkrishna, Sen, Rodrigues, L. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/27800
Resumo: Biosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many therapeutic applications. Mainly due to their surface activity, these molecules interact with cell membranes of several organisms and/or with the surrounding environments, and thus can be viewed as potential cancer therapeutics or as constituents of drug delivery systems. Some types of microbial surfactants, such as lipopeptides and glycolipids, have been shown to selectively inhibit the proliferation of cancer cells and to disrupt cell membranes causing their lysis through apoptosis pathways. Moreover, biosurfactants as drug delivery vehicles offer commercially attractive and scientifically novel applications. This review covers the current state-ofthe- art in biosurfactant research for therapeutic purposes, providing new directions towards the discovery and development of molecules with novel structures and diverse functions for advanced applications.
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spelling Potential therapeutic applications of biosurfactantsbiosurfactantstherapeutic applicationsantitumor agentsdrug delivery systemsScience & TechnologyBiosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many therapeutic applications. Mainly due to their surface activity, these molecules interact with cell membranes of several organisms and/or with the surrounding environments, and thus can be viewed as potential cancer therapeutics or as constituents of drug delivery systems. Some types of microbial surfactants, such as lipopeptides and glycolipids, have been shown to selectively inhibit the proliferation of cancer cells and to disrupt cell membranes causing their lysis through apoptosis pathways. Moreover, biosurfactants as drug delivery vehicles offer commercially attractive and scientifically novel applications. This review covers the current state-ofthe- art in biosurfactant research for therapeutic purposes, providing new directions towards the discovery and development of molecules with novel structures and diverse functions for advanced applications.The authors acknowledge Fundacao para a Ciencia e a Tecnologia (FCT) (Portugal) and the Department of Science and Technology (DST) (India) for financial support of the project 'MEDSURF - The potential use of biosurfactants for medical applications' developed under the scope of a bilateral agreement between Portugal and India.ElsevierElsevier BVUniversidade do MinhoGudiña, Eduardo J.Rangarajan, VivekRamkrishna, SenRodrigues, L. R.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/27800eng0165-614710.1016/j.tips.2013.10.00224182625info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:54:05Zoai:repositorium.sdum.uminho.pt:1822/27800Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:53:36.860994Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potential therapeutic applications of biosurfactants
title Potential therapeutic applications of biosurfactants
spellingShingle Potential therapeutic applications of biosurfactants
Gudiña, Eduardo J.
biosurfactants
therapeutic applications
antitumor agents
drug delivery systems
Science & Technology
title_short Potential therapeutic applications of biosurfactants
title_full Potential therapeutic applications of biosurfactants
title_fullStr Potential therapeutic applications of biosurfactants
title_full_unstemmed Potential therapeutic applications of biosurfactants
title_sort Potential therapeutic applications of biosurfactants
author Gudiña, Eduardo J.
author_facet Gudiña, Eduardo J.
Rangarajan, Vivek
Ramkrishna, Sen
Rodrigues, L. R.
author_role author
author2 Rangarajan, Vivek
Ramkrishna, Sen
Rodrigues, L. R.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Gudiña, Eduardo J.
Rangarajan, Vivek
Ramkrishna, Sen
Rodrigues, L. R.
dc.subject.por.fl_str_mv biosurfactants
therapeutic applications
antitumor agents
drug delivery systems
Science & Technology
topic biosurfactants
therapeutic applications
antitumor agents
drug delivery systems
Science & Technology
description Biosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many therapeutic applications. Mainly due to their surface activity, these molecules interact with cell membranes of several organisms and/or with the surrounding environments, and thus can be viewed as potential cancer therapeutics or as constituents of drug delivery systems. Some types of microbial surfactants, such as lipopeptides and glycolipids, have been shown to selectively inhibit the proliferation of cancer cells and to disrupt cell membranes causing their lysis through apoptosis pathways. Moreover, biosurfactants as drug delivery vehicles offer commercially attractive and scientifically novel applications. This review covers the current state-ofthe- art in biosurfactant research for therapeutic purposes, providing new directions towards the discovery and development of molecules with novel structures and diverse functions for advanced applications.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/27800
url http://hdl.handle.net/1822/27800
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0165-6147
10.1016/j.tips.2013.10.002
24182625
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
Elsevier BV
publisher.none.fl_str_mv Elsevier
Elsevier BV
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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