Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis

Detalhes bibliográficos
Autor(a) principal: Silva, T.M.
Data de Publicação: 2012
Outros Autores: Oredsson, S., Persson, L., Woster, P., Marques, M. P. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/45089
https://doi.org/10.1016/j.jinorgbio.2011.11.021
Resumo: A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.
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spelling Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysisAntineoplastic AgentsPalladiumPlatinumPlatinum CompoundsPolyaminesSpectroscopy, Fourier Transform InfraredSpectrum Analysis, RamanA vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/45089http://hdl.handle.net/10316/45089https://doi.org/10.1016/j.jinorgbio.2011.11.021https://doi.org/10.1016/j.jinorgbio.2011.11.021engSilva, T.M.Oredsson, S.Persson, L.Woster, P.Marques, M. P. M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-24T10:22:39Zoai:estudogeral.uc.pt:10316/45089Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:56:08.103336Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
title Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
spellingShingle Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
Silva, T.M.
Antineoplastic Agents
Palladium
Platinum
Platinum Compounds
Polyamines
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
title_short Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
title_full Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
title_fullStr Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
title_full_unstemmed Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
title_sort Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
author Silva, T.M.
author_facet Silva, T.M.
Oredsson, S.
Persson, L.
Woster, P.
Marques, M. P. M.
author_role author
author2 Oredsson, S.
Persson, L.
Woster, P.
Marques, M. P. M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, T.M.
Oredsson, S.
Persson, L.
Woster, P.
Marques, M. P. M.
dc.subject.por.fl_str_mv Antineoplastic Agents
Palladium
Platinum
Platinum Compounds
Polyamines
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
topic Antineoplastic Agents
Palladium
Platinum
Platinum Compounds
Polyamines
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
description A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/45089
http://hdl.handle.net/10316/45089
https://doi.org/10.1016/j.jinorgbio.2011.11.021
https://doi.org/10.1016/j.jinorgbio.2011.11.021
url http://hdl.handle.net/10316/45089
https://doi.org/10.1016/j.jinorgbio.2011.11.021
dc.language.iso.fl_str_mv eng
language eng
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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