Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient

Detalhes bibliográficos
Autor(a) principal: Fidalgo Martins, I
Data de Publicação: 2022
Outros Autores: Cordeiro, AI, Paiva Lopes, MJ
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4396
Resumo: Cystic lymphangioma (CL) is a rare benign tumor, which occurs typically during childhood, with craniofacial, cervical or axillary being the most common locations. Lymphangiomas management can be challenging due to their permeative growth throughout tissue layers. Sirolimus is an immunosuppressive and antitumor agent that can inhibit abnormal vascular proliferation by blocking the mTOR/PI3K pathway. It is typically well-tolerated, with nausea, cytopenias, and metabolic imbalances as the most significant adverse effects. We present the case of a pediatric patient in which sirolimus was used to treat a macrocytic lymphangioma, highlighting its effectiveness and safety.
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spelling Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric PatientSirolimus no Tratamento de um Linfangioma Quístico num Doente PediátricoLymphangiomaSirolimusChildCase ReportHDE PEDCystic lymphangioma (CL) is a rare benign tumor, which occurs typically during childhood, with craniofacial, cervical or axillary being the most common locations. Lymphangiomas management can be challenging due to their permeative growth throughout tissue layers. Sirolimus is an immunosuppressive and antitumor agent that can inhibit abnormal vascular proliferation by blocking the mTOR/PI3K pathway. It is typically well-tolerated, with nausea, cytopenias, and metabolic imbalances as the most significant adverse effects. We present the case of a pediatric patient in which sirolimus was used to treat a macrocytic lymphangioma, highlighting its effectiveness and safety.Sociedade Portuguesa de DermatologiaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEFidalgo Martins, ICordeiro, AIPaiva Lopes, MJ2023-02-10T11:49:20Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4396engPort J Dermatol and Venereol. 2022;80(3):227-230info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:46:21Zoai:repositorio.chlc.min-saude.pt:10400.17/4396Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:44.554699Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
Sirolimus no Tratamento de um Linfangioma Quístico num Doente Pediátrico
title Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
spellingShingle Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
Fidalgo Martins, I
Lymphangioma
Sirolimus
Child
Case Report
HDE PED
title_short Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
title_full Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
title_fullStr Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
title_full_unstemmed Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
title_sort Sirolimus in the Treatment of Cystic Lymphangioma in a Pediatric Patient
author Fidalgo Martins, I
author_facet Fidalgo Martins, I
Cordeiro, AI
Paiva Lopes, MJ
author_role author
author2 Cordeiro, AI
Paiva Lopes, MJ
author2_role author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Fidalgo Martins, I
Cordeiro, AI
Paiva Lopes, MJ
dc.subject.por.fl_str_mv Lymphangioma
Sirolimus
Child
Case Report
HDE PED
topic Lymphangioma
Sirolimus
Child
Case Report
HDE PED
description Cystic lymphangioma (CL) is a rare benign tumor, which occurs typically during childhood, with craniofacial, cervical or axillary being the most common locations. Lymphangiomas management can be challenging due to their permeative growth throughout tissue layers. Sirolimus is an immunosuppressive and antitumor agent that can inhibit abnormal vascular proliferation by blocking the mTOR/PI3K pathway. It is typically well-tolerated, with nausea, cytopenias, and metabolic imbalances as the most significant adverse effects. We present the case of a pediatric patient in which sirolimus was used to treat a macrocytic lymphangioma, highlighting its effectiveness and safety.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-02-10T11:49:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4396
url http://hdl.handle.net/10400.17/4396
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Port J Dermatol and Venereol. 2022;80(3):227-230
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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