Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae

Detalhes bibliográficos
Autor(a) principal: Mendes, Gabriel
Data de Publicação: 2023
Outros Autores: Santos, Maria Leonor, Ramalho, João Francisco, Duarte, Aida, Caneiras, Catia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/61141
Resumo: Copyright © 2023 Mendes, Santos, Ramalho, Duarte and Caneiras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniaeKlebsiella pneumoniaeSiderophoresHigh-risk clonesST11ST23ST13KPC-variantsTreatmentCopyright © 2023 Mendes, Santos, Ramalho, Duarte and Caneiras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Hypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To better understand the basic biology of these pathogens, this review aimed to describe the virulence factors and their distribution worldwide among carbapenem-resistant highly virulent or hypervirulent K. pneumoniae strains, as well as to understand the interplay of these virulence strains with the carbapenemase produced and the sequence type of such strains. As we witness a shift in healthcare settings where carbapenemresistant highly virulent or hypervirulent K. pneumoniae are beginning to emerge and replace classical K. pneumoniae strains, a better understanding of these strains is urgently needed for immediate and appropriate response.This research was partially funded by Fundação para a Ciência e a Tecnologia (FCT), under grant numbers UIDB/04295/2020 and UIDP/04295/2020. Moreover, CC acknowledges the funding provided by the “Research Award in Healthcare Associated Infections” granted by Escola Superior de Saúde Norte da Cruz Vermelha Portuguesa (2019) and by “BInov award,” an innovation award granted by the Southern Regional Section and Autonomous Regions of the Portuguese Pharmaceutical Society (2021). GM was supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, through a Ph.D. Research Studentship Contract (Contrato de Bolsa de Investigação para Doutoramento 2020.07736.BD).FrontiersRepositório da Universidade de LisboaMendes, GabrielSantos, Maria LeonorRamalho, João FranciscoDuarte, AidaCaneiras, Catia2023-12-05T12:39:25Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61141engFront. Microbiol. 14:132507710.3389/fmicb.2023.13250771664-302Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-11T01:16:23Zoai:repositorio.ul.pt:10451/61141Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:42:11.173003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
title Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
spellingShingle Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, Gabriel
Klebsiella pneumoniae
Siderophores
High-risk clones
ST11
ST23
ST13
KPC-variants
Treatment
title_short Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
title_full Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
title_fullStr Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
title_full_unstemmed Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
title_sort Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
author Mendes, Gabriel
author_facet Mendes, Gabriel
Santos, Maria Leonor
Ramalho, João Francisco
Duarte, Aida
Caneiras, Catia
author_role author
author2 Santos, Maria Leonor
Ramalho, João Francisco
Duarte, Aida
Caneiras, Catia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mendes, Gabriel
Santos, Maria Leonor
Ramalho, João Francisco
Duarte, Aida
Caneiras, Catia
dc.subject.por.fl_str_mv Klebsiella pneumoniae
Siderophores
High-risk clones
ST11
ST23
ST13
KPC-variants
Treatment
topic Klebsiella pneumoniae
Siderophores
High-risk clones
ST11
ST23
ST13
KPC-variants
Treatment
description Copyright © 2023 Mendes, Santos, Ramalho, Duarte and Caneiras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-05T12:39:25Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/61141
url http://hdl.handle.net/10451/61141
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front. Microbiol. 14:1325077
10.3389/fmicb.2023.1325077
1664-302X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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